Gene/Proteome Database (LMPD)

LMPD ID
LMP012416
Gene ID
24565
Species
Rattus norvegicus (Rat)
Gene Name
ATP-binding cassette, subfamily C (CFTR/MRP), member 1
Gene Symbol
Abcc1
Synonyms
Mrp; Mrp1; Abcc1a; Avcc1a;
Alternate Names
multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; multidrug resistance protein 1; ATP-binding cassette sub-family C member 1; multiple drug resistance-associated protein; ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1;
Chromosome
10
Map Location
10q11
Summary
ATP-binding cassette (ABC) multiple drug resistance protein involved in the release of glutathione synthase during oxidative stress [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Abcc1

Proteins

multidrug resistance-associated protein 1
Refseq ID NP_071617
Protein GI 31542029
UniProt ID Q8CG09
mRNA ID NM_022281
Length 1532
MALSSFCSSDGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFLYLSRHDRGYIQMTHLNKAKTALGFFLWIICWADLFYSFWERSQGMLLAPVLLVSPTLLGITMLLATFLIQFERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAQVDMFRDSAFYLYFTLVFIQLVLSCFSDSSPLFSETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAKDAGLV

Gene Information

Entrez Gene ID
24565
Gene Name
ATP-binding cassette, subfamily C (CFTR/MRP), member 1
Gene Symbol
Abcc1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016323 IDA:RGD C basolateral plasma membrane
GO:0005737 IDA:RGD C cytoplasm
GO:0005887 IDA:RGD C integral component of plasma membrane
GO:0016020 IDA:RGD C membrane
GO:0005886 IDA:RGD C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0015238 IDA:RGD F drug transmembrane transporter activity
GO:0015562 IDA:RGD F efflux transmembrane transporter activity
GO:0015431 IMP:RGD F glutathione S-conjugate-exporting ATPase activity
GO:0034634 IMP:RGD F glutathione transmembrane transporter activity
GO:0034040 IDA:RGD F lipid-transporting ATPase activity
GO:0005324 IDA:RGD F long-chain fatty acid transporter activity
GO:0016491 IEA:InterPro F oxidoreductase activity
GO:0046624 IMP:RGD F sphingolipid transporter activity
GO:0008559 IDA:RGD F xenobiotic-transporting ATPase activity
GO:0060326 IMP:RGD P cell chemotaxis
GO:0043215 IMP:RGD P daunorubicin transport
GO:0046618 IDA:RGD P drug export
GO:0006855 IDA:RGD P drug transmembrane transport
GO:0034775 IMP:RGD P glutathione transmembrane transport
GO:1901215 IMP:RGD P negative regulation of neuron death
GO:0033700 IMP:RGD P phospholipid efflux
GO:0015911 IDA:RGD P plasma membrane long-chain fatty acid transport
GO:0030335 IMP:RGD P positive regulation of cell migration
GO:0042493 IDA:RGD P response to drug
GO:0006979 IMP:RGD P response to oxidative stress
GO:0055085 IDA:RGD P transmembrane transport
GO:0042908 IMP:RGD P xenobiotic transport

KEGG Pathway Links

KEGG Pathway ID Description
ko02010 ABC transporters
rno02010 ABC transporters
ko05206 MicroRNAs in cancer
rno05206 MicroRNAs in cancer
ko04977 Vitamin digestion and absorption
rno04977 Vitamin digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR018170 Aldo/keto reductase, conserved site
IPR005292 Multi drug resistance-associated protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ATP-binding cassette, subfamily C (CFTR/MRP), member 1
Protein Entry
MRP1_RAT
UniProt ID
Q8CG09
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CG09-1; Sequence=Displayed; Name=2; IsoId=Q8CG09-2; Sequence=VSP_017015; Note=No experimental confirmation available.;
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency
Ptm Glycosylated.
Similarity Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily
Similarity Contains 2 ABC transmembrane type-1 domains
Similarity Contains 2 ABC transporter domains
Subcellular Location Cell membrane ; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15129170}.
Tissue Specificity Skeletal muscle, brain, heart, spleen, lung and kidney

Identical and Related Proteins

Unique RefSeq proteins for LMP012416 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31542029 RefSeq NP_071617 1532 multidrug resistance-associated protein 1

Identical Sequences to LMP012416 proteins

Reference Database Accession Length Protein Name
GI:31542029 GenBank AAO85437.1 1532 ATP-binding cassette protein C1 [Rattus norvegicus]
GI:31542029 SwissProt Q8CG09.2 1532 RecName: Full=Multidrug resistance-associated protein 1; AltName: Full=ATP-binding cassette sub-family C member 1; AltName: Full=Leukotriene C(4) transporter; Short=LTC4 transporter [Rattus norvegicus]

Related Sequences to LMP012416 proteins

Reference Database Accession Length Protein Name
GI:31542029 GenBank AAN86532.1 1532 multidrug resistance-associated protein 1 [Rattus norvegicus]
GI:31542029 GenBank AAO85437.1 1532 ATP-binding cassette protein C1 [Rattus norvegicus]
GI:31542029 SwissProt Q8CG09.2 1532 RecName: Full=Multidrug resistance-associated protein 1; AltName: Full=ATP-binding cassette sub-family C member 1; AltName: Full=Leukotriene C(4) transporter; Short=LTC4 transporter [Rattus norvegicus]