Gene/Proteome Database (LMPD)
LMPD ID
LMP012417
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
neuraminidase 1
Gene Symbol
Alternate Names
sialidase-1; lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; sialidase 1 (lysosomal sialidase);
Chromosome
20
Map Location
20p12
Summary
enzyme that cleaves sialic acid from glycoproteins and glycolipids [RGD, Feb 2006]
Orthologs
Proteins
| sialidase-1 precursor | |
|---|---|
| Refseq ID | NP_113710 |
| Protein GI | 71896602 |
| UniProt ID | Q6MG70 |
| mRNA ID | NM_031522 |
| Length | 409 |
| MVGAEPSRPPGPPSYWTGRRGQGLAAIFLLLVSAAGSEARTEDDFSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKFIAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGVVFLIYTLCAHKVNCQVASTMLVWSKDDGVSWSPPRNLSVDIGTEMFAPGPGSGIQKQREPWKGRLIVCGHGTLERDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQNNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEYRVNLTLRWSFSNGTSWQKERVQLWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLNRYTESISMVKISVYGTL | |
| sig_peptide: 1..39 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3969 peptide sequence: MVGAEPSRPPGPPSYWTGRRGQGLAAIFLLLVSAAGSEA mat_peptide: 40..409 product: Sialidase-1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99PW3.1) calculated_mol_wt: 40685 peptide sequence: RTEDDFSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKFIAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGVVFLIYTLCAHKVNCQVASTMLVWSKDDGVSWSPPRNLSVDIGTEMFAPGPGSGIQKQREPWKGRLIVCGHGTLERDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQNNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEYRVNLTLRWSFSNGTSWQKERVQLWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLNRYTESISMVKISVYGTL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030054 | IEA:Ensembl | C | cell junction |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0005764 | IEA:Ensembl | C | lysosome |
| GO:0004308 | IEA:Ensembl | F | exo-alpha-sialidase activity |
| GO:0009313 | IEA:Ensembl | P | oligosaccharide catabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04142 | Lysosome |
| rno04142 | Lysosome |
| ko00511 | Other glycan degradation |
| rno00511 | Other glycan degradation |
| ko00600 | Sphingolipid metabolism |
| rno00600 | Sphingolipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953739 | Asparagine N-linked glycosylation |
| 5953738 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 5954485 | Glycosphingolipid metabolism |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953345 | Metabolism of proteins |
| 5953728 | Post-translational protein modification |
| 5954270 | Sialic acid metabolism |
| 5954267 | Sphingolipid metabolism |
| 5953737 | Synthesis of substrates in N-glycan biosythesis |
Domain Information
UniProt Annotations
Entry Information
Identical and Related Proteins
Unique RefSeq proteins for LMP012417 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 71896602 | RefSeq | NP_113710 | 409 | sialidase-1 precursor |
Identical Sequences to LMP012417 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71896602 | EMBL | CAE83976.1 | 409 | neuraminidase 1 [Rattus norvegicus] |
| GI:71896602 | GenBank | AAI00640.1 | 409 | Sialidase 1 (lysosomal sialidase) [Rattus norvegicus] |
| GI:71896602 | GenBank | EDL83469.1 | 409 | neuraminidase 1, isoform CRA_b [Rattus norvegicus] |
Related Sequences to LMP012417 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71896602 | EMBL | CAE83976.1 | 409 | neuraminidase 1 [Rattus norvegicus] |
| GI:71896602 | GenBank | AAI00640.1 | 409 | Sialidase 1 (lysosomal sialidase) [Rattus norvegicus] |
| GI:71896602 | GenBank | EDL83469.1 | 409 | neuraminidase 1, isoform CRA_b [Rattus norvegicus] |