Gene/Proteome Database (LMPD)
LMPD ID
LMP012419
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
propionyl CoA carboxylase, beta polypeptide
Gene Symbol
Alternate Names
propionyl-CoA carboxylase beta chain, mitochondrial; PCCase subunit beta; propanoyl-CoA:carbon dioxide ligase subunit beta; propionyl coenzyme A carboxylase, beta polypeptide;
Chromosome
8
Map Location
8q31
Summary
beta subunit of propionyl coenzyme A, which catalyzes the conversion of ATP, propanoyl-CoA, and HCO3- to ADP, phosphate, and (S)-methylmalonyl-CoA [RGD, Feb 2006]
Orthologs
Proteins
| propionyl-CoA carboxylase beta chain, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_058726 |
| Protein GI | 148747119 |
| UniProt ID | Q68FZ8 |
| mRNA ID | NM_017030 |
| Length | 541 |
| MAAAIRIRAMAAGTRLRVLNCGLRTTIRSLCSQPVSVNERIENKRHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAAEKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPEVVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREFFNFLPLSNQDPAPIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEIMPNYAKNIVIGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFSIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLLGDTNYAWPTAEIAVMGAKGAVEIIFKGHQDVEAAQAEYVEKFANPFPAAVRGFVDDIIQPSSTRARICCDLEVLASKKVHRPWRKHANVPL | |
| transit_peptide: 1..28 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P07633.1) calculated_mol_wt: 3057 peptide sequence: MAAAIRIRAMAAGTRLRVLNCGLRTTIR mat_peptide: 29..541 product: Propionyl-CoA carboxylase beta chain, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P07633.1) calculated_mol_wt: 55640 peptide sequence: SLCSQPVSVNERIENKRHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAAEKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPEVVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREFFNFLPLSNQDPAPIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEIMPNYAKNIVIGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFSIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLLGDTNYAWPTAEIAVMGAKGAVEIIFKGHQDVEAAQAEYVEKFANPFPAAVRGFVDDIIQPSSTRARICCDLEVLASKKVHRPWRKHANVPL | |
Gene Information
Entrez Gene ID
Gene Name
propionyl CoA carboxylase, beta polypeptide
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IEA:Ensembl | C | mitochondrion |
| GO:0016874 | IEA:InterPro | F | ligase activity |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko01200 | Carbon metabolism |
| rno01200 | Carbon metabolism |
| ko00630 | Glyoxylate and dicarboxylate metabolism |
| rno00630 | Glyoxylate and dicarboxylate metabolism |
| rno01100 | Metabolic pathways |
| ko00640 | Propanoate metabolism |
| rno00640 | Propanoate metabolism |
| ko00280 | Valine, leucine and isoleucine degradation |
| rno00280 | Valine, leucine and isoleucine degradation |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-5130 | 2-oxobutanoate degradation I |
| PWY-5328 | superpathway of methionine salvage and degradation |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954011 | Biotin transport and metabolism |
| 5953298 | Defective AMN causes hereditary megaloblastic anemia 1 |
| 5953308 | Defective BTD causes biotidinase deficiency |
| 5953307 | Defective CD320 causes methylmalonic aciduria |
| 5953299 | Defective CUBN causes hereditary megaloblastic anemia 1 |
| 5953296 | Defective GIF causes intrinsic factor deficiency |
| 5953310 | Defective HLCS causes multiple carboxylase deficiency |
| 5953297 | Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF |
| 5953305 | Defective MMAA causes methylmalonic aciduria type cblA |
| 5953302 | Defective MMAB causes methylmalonic aciduria type cblB |
| 5953304 | Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC |
| 5953303 | Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD |
| 5953301 | Defective MTR causes methylmalonic aciduria and homocystinuria type cblG |
| 5953300 | Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE |
| 5953306 | Defective MUT causes methylmalonic aciduria mut type |
| 5953293 | Defective TCN2 causes hereditary megaloblastic anemia |
| 5953309 | Defects in biotin (Btn) metabolism |
| 5953294 | Defects in cobalamin (B12) metabolism |
| 5953295 | Defects in vitamin and cofactor metabolism |
| 5953253 | Disease |
| 5953288 | Fatty acid, triacylglycerol, and ketone body metabolism |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953292 | Metabolism of vitamins and cofactors |
| 5953291 | Metabolism of water-soluble vitamins and cofactors |
| 5953287 | Mitochondrial Fatty Acid Beta-Oxidation |
| 5953286 | Propionyl-CoA catabolism |
Domain Information
UniProt Annotations
Entry Information
Gene Name
propionyl CoA carboxylase, beta polypeptide
Protein Entry
Q68FZ8_RAT
UniProt ID
Species
Rat
Identical and Related Proteins
Unique RefSeq proteins for LMP012419 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 148747119 | RefSeq | NP_058726 | 541 | propionyl-CoA carboxylase beta chain, mitochondrial precursor |
Identical Sequences to LMP012419 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:148747119 | GenBank | AAH78855.1 | 541 | Propionyl coenzyme A carboxylase, beta polypeptide [Rattus norvegicus] |
| GI:148747119 | GenBank | EDL77415.1 | 541 | propionyl coenzyme A carboxylase, beta polypeptide, isoform CRA_b [Rattus norvegicus] |
Related Sequences to LMP012419 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:148747119 | GenBank | AAH78855.1 | 541 | Propionyl coenzyme A carboxylase, beta polypeptide [Rattus norvegicus] |
| GI:148747119 | GenBank | EDL77415.1 | 541 | propionyl coenzyme A carboxylase, beta polypeptide, isoform CRA_b [Rattus norvegicus] |
| GI:148747119 | SwissProt | P07633.1 | 541 | RecName: Full=Propionyl-CoA carboxylase beta chain, mitochondrial; Short=PCCase subunit beta; AltName: Full=Propanoyl-CoA:carbon dioxide ligase subunit beta; Flags: Precursor [Rattus norvegicus] |