Gene/Proteome Database (LMPD)

LMPD ID
LMP012422
Gene ID
24654
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Gene Symbol
Plcb1
Synonyms
PLC'1; Phosphb; PLCbeta1; RATPHOSPHB;
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-I; PLC-154; PLC-beta-1; phospholipase C-I; Phospholipase C-beta1; phospholipase C-beta-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1;
Chromosome
3
Map Location
3q36
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Refseq ID NP_001071109
Protein GI 117647200
UniProt ID P10687
mRNA ID NM_001077641
Length 1216
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQMELEQEYQDKFKRLPLEILEFVQEAMKGKVSEDSNHGSAPPSLASDPAKVNLKSPSSEEVQGENAGREFDTPL

Gene Information

Entrez Gene ID
24654
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Gene Symbol
Plcb1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:BHF-UCL C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0016020 IDA:RGD C membrane
GO:0016607 ISS:BHF-UCL C nuclear speck
GO:0005634 ISS:BHF-UCL C nucleus
GO:0005509 IDA:BHF-UCL F calcium ion binding
GO:0004435 IDA:RGD F phosphatidylinositol phospholipase C activity
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0060466 ISS:BHF-UCL P activation of meiosis involved in egg activation
GO:0021987 ISS:BHF-UCL P cerebral cortex development
GO:0007215 ISS:BHF-UCL P glutamate receptor signaling pathway
GO:0048009 ISS:BHF-UCL P insulin-like growth factor receptor signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0007612 IEP:RGD P learning
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0007613 IEP:RGD P memory
GO:2000438 ISS:BHF-UCL P negative regulation of monocyte extravasation
GO:0045892 ISS:BHF-UCL P negative regulation of transcription, DNA-templated
GO:0046488 IEP:RGD P phosphatidylinositol metabolic process
GO:2000560 ISS:BHF-UCL P positive regulation of CD24 biosynthetic process
GO:1900087 ISS:BHF-UCL P positive regulation of G1/S transition of mitotic cell cycle
GO:0048639 ISS:BHF-UCL P positive regulation of developmental growth
GO:0032735 ISS:BHF-UCL P positive regulation of interleukin-12 production
GO:0045663 ISS:BHF-UCL P positive regulation of myoblast differentiation
GO:0045893 ISS:BHF-UCL P positive regulation of transcription, DNA-templated
GO:0008277 ISS:BHF-UCL P regulation of G-protein coupled receptor protein signaling pathway
GO:0034284 IDA:BHF-UCL P response to monosaccharide
GO:0010243 IEP:RGD P response to organonitrogen compound
GO:0043434 IDA:BHF-UCL P response to peptide hormone

KEGG Pathway Links

KEGG Pathway ID Description
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko05143 African trypanosomiasis
rno05143 African trypanosomiasis
ko05010 Alzheimer's disease
rno05010 Alzheimer's disease
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko04713 Circadian entrainment
rno04713 Circadian entrainment
ko04728 Dopaminergic synapse
rno04728 Dopaminergic synapse
ko04961 Endocrine and other factor-regulated calcium reabsorption
rno04961 Endocrine and other factor-regulated calcium reabsorption
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04540 Gap junction
rno04540 Gap junction
ko04971 Gastric acid secretion
rno04971 Gastric acid secretion
ko04724 Glutamatergic synapse
rno04724 Glutamatergic synapse
ko04912 GnRH signaling pathway
rno04912 GnRH signaling pathway
ko05016 Huntington's disease
rno05016 Huntington's disease
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno04911 Insulin secretion
ko04730 Long-term depression
rno04730 Long-term depression
ko04720 Long-term potentiation
rno04720 Long-term potentiation
ko04916 Melanogenesis
rno04916 Melanogenesis
rno01100 Metabolic pathways
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04611 Platelet activation
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
ko04723 Retrograde endocannabinoid signaling
rno04723 Retrograde endocannabinoid signaling
ko04970 Salivary secretion
rno04970 Salivary secretion
rno04726 Serotonergic synapse
rno04919 Thyroid hormone signaling pathway
ko04918 Thyroid hormone synthesis
rno04918 Thyroid hormone synthesis
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko04310 Wnt signaling pathway
rno04310 Wnt signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028400 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Protein Entry
PLCB1_RAT
UniProt ID
P10687
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Miscellaneous The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Nucleus membrane . Cytoplasm . Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes
Subunit Interacts with DGKQ
Tissue Specificity Highest expression in brain. Also expressed in parotid gland, liver, uterus, lung, heart, adrenal gland and ovary. Not detected in spleen, pancreas, intestine, thymus or kidney

Identical and Related Proteins

Unique RefSeq proteins for LMP012422 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
117647200 RefSeq NP_001071109 1216 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Identical Sequences to LMP012422 proteins

Reference Database Accession Length Protein Name
GI:117647200 GenBank AAA41885.1 1216 phospholipase C-1 [Rattus sp.]
GI:117647200 RefSeq XP_008760469.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [Rattus norvegicus]
GI:117647200 SwissProt P10687.1 1216 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; AltName: Full=PLC-154; AltName: Full=Phosphoinositide phospholipase C-beta-1; AltName: Full=Phospholipase C-I; Short=PLC-I; AltName: Full=Phospholipase C-beta-1; Short=PLC-beta-1 [Rattus norvegicus]

Related Sequences to LMP012422 proteins

Reference Database Accession Length Protein Name
GI:117647200 GenBank AAA41885.1 1216 phospholipase C-1 [Rattus sp.]
GI:117647200 RefSeq XP_008760469.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [Rattus norvegicus]
GI:117647200 SwissProt P10687.1 1216 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; AltName: Full=PLC-154; AltName: Full=Phosphoinositide phospholipase C-beta-1; AltName: Full=Phospholipase C-I; Short=PLC-I; AltName: Full=Phospholipase C-beta-1; Short=PLC-beta-1 [Rattus norvegicus]