Gene/Proteome Database (LMPD)

LMPD ID
LMP012423
Gene ID
24655
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C, delta 1
Gene Symbol
Plcd1
Synonyms
Plc1;
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; PLC-III; PLC-delta-1; phospholipase C-III; Phospholipase C-delta1; phospholipase C-delta-1; phosphoinositide phospholipase C; phospholipase C delta 1 long form; phosphoinositide phospholipase C-delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1;
Chromosome
8
Map Location
8q32
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Refseq ID NP_058731
Protein GI 8393981
UniProt ID P10688
mRNA ID NM_017035
Length 756
MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD

Gene Information

Entrez Gene ID
24655
Gene Name
phospholipase C, delta 1
Gene Symbol
Plcd1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0016020 IDA:RGD C membrane
GO:0045121 IDA:RGD C membrane raft
GO:0031966 IDA:RGD C mitochondrial membrane
GO:0005634 IDA:RGD C nucleus
GO:0005509 IDA:RGD F calcium ion binding
GO:0005546 IDA:RGD F phosphatidylinositol-4,5-bisphosphate binding
GO:0004435 IDA:RGD F phosphatidylinositol phospholipase C activity
GO:0005543 IDA:RGD F phospholipid binding
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0051480 IMP:RGD P cytosolic calcium ion homeostasis
GO:0007186 IDA:RGD P G-protein coupled receptor signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0051482 IMP:RGD P positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0032962 IMP:RGD P positive regulation of inositol trisphosphate biosynthetic process
GO:0010701 IMP:RGD P positive regulation of norepinephrine secretion
GO:1900274 IMP:RGD P regulation of phospholipase C activity
GO:0010044 IEP:RGD P response to aluminum ion
GO:0051592 IMP:RGD P response to calcium ion
GO:0055093 IEP:RGD P response to hyperoxia
GO:0010243 IEP:RGD P response to organonitrogen compound
GO:0043434 IMP:RGD P response to peptide hormone
GO:0034696 IEP:RGD P response to prostaglandin F

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028391 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, delta 1
Protein Entry
PLCD1_RAT
UniProt ID
P10688
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012423 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393981 RefSeq NP_058731 756 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Identical Sequences to LMP012423 proteins

Reference Database Accession Length Protein Name
GI:8393981 GenBank AAA41886.1 756 phospholipase C-III [Rattus sp.]
GI:8393981 GenBank ABH83691.1 756 Sequence 11 from patent US 7049089
GI:8393981 SwissProt P10688.1 756 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; AltName: Full=Phosphoinositide phospholipase C-delta-1; AltName: Full=Phospholipase C-III; Short=PLC-III; AltName: Full=Phospholipase C-delta-1; Short=PLC-delta-1 [Rattus norvegicus]

Related Sequences to LMP012423 proteins

Reference Database Accession Length Protein Name
GI:8393981 GenBank AAA41886.1 756 phospholipase C-III [Rattus sp.]
GI:8393981 GenBank ABH83691.1 756 Sequence 11 from patent US 7049089
GI:8393981 SwissProt P10688.1 756 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; AltName: Full=Phosphoinositide phospholipase C-delta-1; AltName: Full=Phospholipase C-III; Short=PLC-III; AltName: Full=Phospholipase C-delta-1; Short=PLC-delta-1 [Rattus norvegicus]