Gene/Proteome Database (LMPD)

LMPD ID
LMP012427
Gene ID
24693
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin-endoperoxide synthase 1
Gene Symbol
Ptgs1
Synonyms
Cox1; Cox3; Cox-1; Cox-3; Pghs-1;
Alternate Names
prostaglandin G/H synthase 1; PHS 1; PGH synthase 1; cyclooxygenase 3; cyclooxygenase-1; prostaglandin H2 synthase 1; prostaglandin G/H synthase and cyclooxygenase;
Chromosome
3
Map Location
3p11
Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
Orthologs
View orthologs and multiple alignments for Ptgs1

Proteins

prostaglandin G/H synthase 1 precursor
Refseq ID NP_058739
Protein GI 577861042
UniProt ID Q66HK3
mRNA ID NM_017043
Length 602
MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVLTVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLAQRLLLRREFIPAPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL
sig_peptide: 1..26 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2941 peptide sequence: MSRRSLSLQFPLLLLLLLLPPPPVLL mat_peptide: 27..602 product: Prostaglandin G/H synthase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q63921.2) calculated_mol_wt: 66124 peptide sequence: TDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVLTVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLAQRLLLRREFIPAPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL

Gene Information

Entrez Gene ID
24693
Gene Name
prostaglandin-endoperoxide synthase 1
Gene Symbol
Ptgs1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0001750 IEA:Ensembl C photoreceptor outer segment
GO:0020037 IEA:InterPro F heme binding
GO:0004601 IEA:InterPro F peroxidase activity
GO:0004666 IEA:Ensembl F prostaglandin-endoperoxide synthase activity
GO:0019371 IEA:Ensembl P cyclooxygenase pathway
GO:0006954 IEA:InterPro P inflammatory response
GO:0008217 IEA:Ensembl P regulation of blood pressure
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0006979 IEA:InterPro P response to oxidative stress

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
rno01100 Metabolic pathways
rno04611 Platelet activation
rno04726 Serotonergic synapse

REACTOME Pathway Links

REACTOME Pathway ID Description
5953493 Arachidonic acid metabolism
5953258 Biological oxidations
5953666 COX reactions
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953326 Phase 1 - Functionalization of compounds
5953492 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Domain Information

InterPro Annotations

Accession Description
IPR000742 Epidermal growth factor-like domain
IPR010255 Haem_peroxidase
IPR019791 Haem peroxidase, animal
IPR029580 Prostaglandin G/H synthase 1

UniProt Annotations

Entry Information

Gene Name
prostaglandin-endoperoxide synthase 1
Protein Entry
Q66HK3_RAT
UniProt ID
Q66HK3
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012427 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
577861042 RefSeq NP_058739 602 prostaglandin G/H synthase 1 precursor

Identical Sequences to LMP012427 proteins

Reference Database Accession Length Protein Name
GI:577861042 GenBank AAH81816.1 602 Ptgs1 protein [Rattus norvegicus]
GI:577861042 GenBank EDL93122.1 602 rCG45926, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012427 proteins

Reference Database Accession Length Protein Name
GI:577861042 GenBank AAH81816.1 602 Ptgs1 protein [Rattus norvegicus]
GI:577861042 GenBank EDL93122.1 602 rCG45926, isoform CRA_a [Rattus norvegicus]
GI:577861042 SwissProt Q63921.2 602 RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; AltName: Full=Prostaglandin-endoperoxide synthase 1; Flags: Precursor [Rattus norvegicus]