Gene/Proteome Database (LMPD)

LMPD ID
LMP012433
Gene ID
24763
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA synthetase medium-chain family member 3
Gene Symbol
Acsm3
Synonyms
Sa; Sah;
Alternate Names
acyl-coenzyme A synthetase ACSM3, mitochondrial; ssubA; protein SA; butyrate--CoA ligase 3; butyryl coenzyme A synthetase 3; butyryl-coenzyme A synthetase 3; SA hypertension-associated homolog; middle-chain acyl-CoA synthetase 3; SA rat hypertension-associated homolog; SA rat hypertension-associated protein;
Chromosome
1
Map Location
1q35
EC Number
6.2.1.2
Summary
may be a component of genetic hypertension [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acsm3

Proteins

acyl-coenzyme A synthetase ACSM3, mitochondrial
Refseq ID NP_150234
Protein GI 65301416
UniProt ID Q6SKG1
mRNA ID NM_033231
Length 580
MAMLLRARCFHRLAIPDPRRILYKDYRTAIPQNFSNYESMKHDFKIEIPEYFNFAKDVLDQWTNTEKTGKRLSNPAFWWVDGNGKEVRWSFEELGSLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKSKCIITDDTLAPAVDIVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDTKHNELMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFDSTSILQTLSKFPITVFCSAPTAYRMLIQNDITSYKFNSLKHCVSAGEPINPEVMEQWKKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFNVEILDENGTILPPGQEGDIAVQVLPDRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDEDGYFWFVARSDDVILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKLHDQEQLKKEIQEHVKKTTAPYKYPRKIEFIEELPKTVSGKVKRNELRRKEWTTT
transit_peptide: 1..21 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q6SKG1.1) calculated_mol_wt: 2537 peptide sequence: MAMLLRARCFHRLAIPDPRRI mat_peptide: 22..580 product: Acyl-coenzyme A synthetase ACSM3, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6SKG1.1) calculated_mol_wt: 63194 peptide sequence: LYKDYRTAIPQNFSNYESMKHDFKIEIPEYFNFAKDVLDQWTNTEKTGKRLSNPAFWWVDGNGKEVRWSFEELGSLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKSKCIITDDTLAPAVDIVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDTKHNELMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFDSTSILQTLSKFPITVFCSAPTAYRMLIQNDITSYKFNSLKHCVSAGEPINPEVMEQWKKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFNVEILDENGTILPPGQEGDIAVQVLPDRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDEDGYFWFVARSDDVILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKLHDQEQLKKEIQEHVKKTTAPYKYPRKIEFIEELPKTVSGKVKRNELRRKEWTTT

Gene Information

Entrez Gene ID
24763
Gene Name
acyl-CoA synthetase medium-chain family member 3
Gene Symbol
Acsm3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IEA:Ensembl C mitochondrial matrix
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0015645 IEA:Ensembl F fatty acid ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006633 IEA:Ensembl P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR025110 AMP-binding enzyme C-terminal domain
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 3
Protein Entry
ACSM3_RAT
UniProt ID
Q6SKG1
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Subcellular Location Mitochondrion matrix .

Identical and Related Proteins

Unique RefSeq proteins for LMP012433 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
65301416 RefSeq NP_150234 580 acyl-coenzyme A synthetase ACSM3, mitochondrial

Identical Sequences to LMP012433 proteins

Reference Database Accession Length Protein Name
GI:65301416 EMBL CBN62051.1 580 unnamed protein product [Rattus norvegicus]
GI:65301416 EMBL CBN59834.1 580 unnamed protein product [Rattus norvegicus]
GI:65301416 GenBank EDM17651.1 580 SA rat hypertension-associated gene, isoform CRA_a [Rattus norvegicus]
GI:65301416 GenBank EDM17652.1 580 SA rat hypertension-associated gene, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012433 proteins

Reference Database Accession Length Protein Name
GI:65301416 EMBL CBN62051.1 580 unnamed protein product [Rattus norvegicus]
GI:65301416 EMBL CBN59834.1 580 unnamed protein product [Rattus norvegicus]
GI:65301416 GenBank EDM17651.1 580 SA rat hypertension-associated gene, isoform CRA_a [Rattus norvegicus]