Gene/Proteome Database (LMPD)

LMPD ID
LMP012434
Gene ID
24775
Species
Rattus norvegicus (Rat)
Gene Name
sex hormone binding globulin
Gene Symbol
Shbg
Synonyms
Abpa;
Alternate Names
sex hormone-binding globulin; ABP; SBP; androgen binding protein; sex steroid-binding protein; testis-specific androgen-binding protein; Sex hormone binding globulin or androgen-binding protein (other gene product from ABP gene);
Chromosome
10
Map Location
10q24
Summary
plays a role in extracellular transport of androgens [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Shbg

Proteins

sex hormone-binding globulin precursor
Refseq ID NP_036782
Protein GI 6981532
UniProt ID P08689
mRNA ID NM_012650
Length 403
MEKGEVASLRCRLLLLLLLLTLPPTHQGRTLRHIDPIQSAQDSPAKYLSNGPGQEPVTVLTIDLTKISKPSSSFEFRTWDPEGVIFYGDTNTEDDWFMLGLRDGQLEIQLHNLWARLTVGFGPRLNDGRWHPVELKMNGDSLLLWVDGKEMLCLRQVSASLADHPQLSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSTSARTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHTDPWTFSLELGFKLVDGAGRLLTLGTGTNSSWLTLHLQDQTVVLSSEAEPKLALPLAVGLPLQLKLDVFKVALSQGPKMEVLSTSLLRLASLWRLWSHPQGHLSLGALPGEDSSASFCLSDLWVQGQRLDIDKALSRSQDIWTHSCPQSPSNDTHTSH
sig_peptide: 1..30 note: androgen binding protein signal peptide calculated_mol_wt: 3373 peptide sequence: MEKGEVASLRCRLLLLLLLLTLPPTHQGRT mat_peptide: 31..403 product: sex hormone-binding globulin calculated_mol_wt: 41178 peptide sequence: LRHIDPIQSAQDSPAKYLSNGPGQEPVTVLTIDLTKISKPSSSFEFRTWDPEGVIFYGDTNTEDDWFMLGLRDGQLEIQLHNLWARLTVGFGPRLNDGRWHPVELKMNGDSLLLWVDGKEMLCLRQVSASLADHPQLSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSTSARTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHTDPWTFSLELGFKLVDGAGRLLTLGTGTNSSWLTLHLQDQTVVLSSEAEPKLALPLAVGLPLQLKLDVFKVALSQGPKMEVLSTSLLRLASLWRLWSHPQGHLSLGALPGEDSSASFCLSDLWVQGQRLDIDKALSRSQDIWTHSCPQSPSNDTHTSH

Gene Information

Entrez Gene ID
24775
Gene Name
sex hormone binding globulin
Gene Symbol
Shbg
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 TAS:RGD C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005496 IEA:UniProtKB-KW F steroid binding
GO:0007285 IMP:RGD P primary spermatocyte growth

Domain Information

InterPro Annotations

Accession Description
IPR013320 Concanavalin A-like lectin/glucanase domain
IPR001791 Laminin G domain

UniProt Annotations

Entry Information

Gene Name
sex hormone binding globulin
Protein Entry
SHBG_RAT
UniProt ID
P08689
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P08689-1; Sequence=Displayed; Name=2; IsoId=P08689-2; Sequence=VSP_006093, VSP_006094; Note=Incomplete sequence.;
Developmental Stage In the fetal liver, expressed from day 14 to day 17 after conception.
Function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity)
Miscellaneous A putative trans-splicing which involves HDC and SHBG gene regions produces a fusion protein expressed in fetal liver.
Similarity Contains 2 laminin G-like domains
Subcellular Location Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
Subunit Homodimer.
Tissue Specificity Isoform 2 is only expressed in the liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012434 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981532 RefSeq NP_036782 403 sex hormone-binding globulin precursor

Identical Sequences to LMP012434 proteins

Reference Database Accession Length Protein Name
GI:6981532 GenBank AAA40648.1 403 androgen binding protein precursor [Rattus norvegicus]
GI:6981532 GenBank AAA40650.1 403 androgen binding protein [Rattus norvegicus]
GI:6981532 GenBank AAH97336.1 403 Sex hormone binding globulin [Rattus norvegicus]
GI:6981532 GenBank EDM04875.1 403 sex hormone binding globulin [Rattus norvegicus]

Related Sequences to LMP012434 proteins

Reference Database Accession Length Protein Name
GI:6981532 GenBank AAA40648.1 403 androgen binding protein precursor [Rattus norvegicus]
GI:6981532 GenBank AAA40650.1 403 androgen binding protein [Rattus norvegicus]
GI:6981532 SwissProt P08689.1 403 RecName: Full=Sex hormone-binding globulin; Short=SHBG; AltName: Full=Sex steroid-binding protein; Short=SBP; AltName: Full=Testis-specific androgen-binding protein; Short=ABP; Flags: Precursor [Rattus norvegicus]