Gene/Proteome Database (LMPD)

LMPD ID
LMP012435
Gene ID
24777
Species
Rattus norvegicus (Rat)
Gene Name
solute carrier family 10 (sodium/bile acid cotransporter), member 1
Gene Symbol
Slc10a1
Synonyms
Ntcp; Ntcp1; SBACT;
Alternate Names
sodium/bile acid cotransporter; Na(+)/bile acid cotransporter; solute carrier family 10, member 1; Na(+)/taurocholate transport protein; sodium-dependent bile acid cotransporter; NA-dependent cholate transporting protein; sodium/taurocholate cotransporting polypeptide; sodium-dependent taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family), member 1;
Chromosome
6
Map Location
6q24
Summary
mediates sodium dependent bile acid transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Slc10a1

Proteins

sodium/bile acid cotransporter
Refseq ID NP_058743
Protein GI 8394279
UniProt ID P26435
mRNA ID NM_017047
Length 362
MEVHNVSAPFNFSLPPGFGHRATDKALSIILVLMLLLIMLSLGCTMEFSKIKAHLWKPKGVIVALVAQFGIMPLAAFLLGKIFHLSNIEALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFSALGMMPLLLYVYSKGIYDGDLKDKVPYKGIMISLVIVLIPCTIGIVLKSKRPHYVPYILKGGMIITFLLSVAVTALSVINVGNSIMFVMTPHLLATSSLMPFSGFLMGYILSALFQLNPSCRRTISMETGFQNIQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLIIIIFRCYEKIKPPKDQTKITYKAAATEDATPAALEKGTHNGNIPPLQPGPSPNGLNSGQMAN

Gene Information

Entrez Gene ID
24777
Gene Name
solute carrier family 10 (sodium/bile acid cotransporter), member 1
Gene Symbol
Slc10a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016323 IDA:RGD C basolateral plasma membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0015125 IDA:RGD F bile acid transmembrane transporter activity
GO:0008508 IDA:RGD F bile acid:sodium symporter activity
GO:0015721 IDA:RGD P bile acid and bile salt transport

KEGG Pathway Links

KEGG Pathway ID Description
ko04976 Bile secretion
rno04976 Bile secretion

REACTOME Pathway Links

REACTOME Pathway ID Description
5953720 Bile acid and bile salt metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953719 Recycling of bile acids and salts

Domain Information

InterPro Annotations

Accession Description
IPR004710 Bile acid:sodium symporter
IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3

UniProt Annotations

Entry Information

Gene Name
solute carrier family 10 (sodium/bile acid cotransporter), member 1
Protein Entry
NTCP_RAT
UniProt ID
P26435
Species
Rat

Comments

Comment Type Description
Function The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
Similarity Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP012435 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8394279 RefSeq NP_058743 362 sodium/bile acid cotransporter

Identical Sequences to LMP012435 proteins

Reference Database Accession Length Protein Name
GI:8394279 GenBank AAA42112.1 362 sodium/bile acid cotransporter [Rattus norvegicus]
GI:8394279 GenBank AAH91152.1 362 Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 [Rattus norvegicus]
GI:8394279 GenBank EDL81408.1 362 solute carrier family 10 (sodium/bile acid cotransporter family), member 1, isoform CRA_b [Rattus norvegicus]
GI:8394279 GenBank AEK13627.1 362 Sequence 39 from patent US 7972785

Related Sequences to LMP012435 proteins

Reference Database Accession Length Protein Name
GI:8394279 GenBank AAA42112.1 362 sodium/bile acid cotransporter [Rattus norvegicus]
GI:8394279 GenBank EDL81408.1 362 solute carrier family 10 (sodium/bile acid cotransporter family), member 1, isoform CRA_b [Rattus norvegicus]
GI:8394279 SwissProt P26435.1 362 RecName: Full=Sodium/bile acid cotransporter; AltName: Full=Na(+)/bile acid cotransporter; AltName: Full=Na(+)/taurocholate transport protein; AltName: Full=Sodium/taurocholate cotransporting polypeptide; AltName: Full=Solute carrier family 10 member 1 [Rattus norvegicus]