Gene/Proteome Database (LMPD)

LMPD ID
LMP012436
Gene ID
24800
Species
Rattus norvegicus (Rat)
Gene Name
steroid sulfatase (microsomal), isozyme S
Gene Symbol
Sts
Alternate Names
steryl-sulfatase; ASC; arylsulfatase C; steryl-sulfate sulfohydrolase;
Chromosome
X
Map Location
Xq12-q14
EC Number
3.1.6.2
Summary
enzyme that converts sulfated precursors to estrogen during pregnancy [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Sts

Proteins

steryl-sulfatase precursor
Refseq ID NP_036793
Protein GI 6981598
UniProt ID P15589
mRNA ID NM_012661
Length 577
MLWPCLLALLLSQLNFLCAARPGPGPNFLLIMADDLGIGDLGCYGNRTLRTPHIDRLALEGVKLTQHLAAAPLCTPSRAAFLTGRYPVRSGMASHGRLGVFLFSASSGGLPPNEVTFAKLLKGQGYTTGLVGKWHLGLSCQAASDFCHHPGRHGFDRFLGTPTTNLRDCKPGGGTVFGSAQQVFVVLPMNILGAVLLAMALARWAGLARPPGWVFGVTVAAMAAVGGAYVAFLYHFRPANCFLMADFTITQQPTDYKGLTQRLASEAGDFLRRNRDTPFLLFLSFMHVHTAHFANPEFAGQSLHGAYGDAVEEMDWAVGQVLATLDKLGLANNTLVYLTSDHGAHVEELGPNGERHGGSNGIYRGGKANTWEGGIRVPGLVRWPGVIVPGQEVEEPTSNMDVFPTVARLAGAELPTDRVIDGRDLMPLLLGHVQHSEHEFLFHYCNAYLSAVAWRPHNSSSVWKAFYFTPNFDPPGSNGCFSTHVCMCHGHHVTHHDPPLLFDIARDPRERHPLTPETEPRHGEILRNMDAAARAHVATLEEAPNQLSMSNVAWKPWLQLCLPSKPHPLACRCAGDG
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2163 peptide sequence: MLWPCLLALLLSQLNFLCA mat_peptide: 20..577 product: Steryl-sulfatase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P15589.2) calculated_mol_wt: 60534 peptide sequence: ARPGPGPNFLLIMADDLGIGDLGCYGNRTLRTPHIDRLALEGVKLTQHLAAAPLCTPSRAAFLTGRYPVRSGMASHGRLGVFLFSASSGGLPPNEVTFAKLLKGQGYTTGLVGKWHLGLSCQAASDFCHHPGRHGFDRFLGTPTTNLRDCKPGGGTVFGSAQQVFVVLPMNILGAVLLAMALARWAGLARPPGWVFGVTVAAMAAVGGAYVAFLYHFRPANCFLMADFTITQQPTDYKGLTQRLASEAGDFLRRNRDTPFLLFLSFMHVHTAHFANPEFAGQSLHGAYGDAVEEMDWAVGQVLATLDKLGLANNTLVYLTSDHGAHVEELGPNGERHGGSNGIYRGGKANTWEGGIRVPGLVRWPGVIVPGQEVEEPTSNMDVFPTVARLAGAELPTDRVIDGRDLMPLLLGHVQHSEHEFLFHYCNAYLSAVAWRPHNSSSVWKAFYFTPNFDPPGSNGCFSTHVCMCHGHHVTHHDPPLLFDIARDPRERHPLTPETEPRHGEILRNMDAAARAHVATLEEAPNQLSMSNVAWKPWLQLCLPSKPHPLACRCAGDG

Gene Information

Entrez Gene ID
24800
Gene Name
steroid sulfatase (microsomal), isozyme S
Gene Symbol
Sts
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:RGD C endoplasmic reticulum membrane
GO:0016021 IDA:RGD C integral component of membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005635 IDA:RGD C nuclear envelope
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004773 IDA:RGD F steryl-sulfatase activity
GO:0007565 IEA:UniProtKB-KW P female pregnancy
GO:0007611 IMP:RGD P learning or memory
GO:0008284 IMP:RGD P positive regulation of cell proliferation
GO:0043627 IDA:RGD P response to estrogen
GO:0014070 IDA:RGD P response to organic cyclic compound
GO:0043434 IDA:RGD P response to peptide hormone
GO:0009268 IDA:RGD P response to pH
GO:0043588 IEP:RGD P skin development
GO:0008202 IEA:UniProtKB-KW P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954485 Glycosphingolipid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953345 Metabolism of proteins
5953728 Post-translational protein modification
5953727 PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
5954267 Sphingolipid metabolism
5954489 The activation of arylsulfatases

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR000917 Sulfatase
IPR024607 Sulfatase, conserved site

UniProt Annotations

Entry Information

Gene Name
steroid sulfatase (microsomal), isozyme S
Protein Entry
STS_RAT
UniProt ID
P15589
Species
Rat

Comments

Comment Type Description
Catalytic Activity 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 1 Ca(2+) ion per subunit. ;
Function Conversion of sulfated steroid precursors to estrogens during pregnancy.
Ptm The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity
Similarity Belongs to the sulfatase family
Subcellular Location Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein . Note=The sequence shows several membrane-spanning domains that could serve to anchor the protein in the microsomal membrane.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012436 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981598 RefSeq NP_036793 577 steryl-sulfatase precursor

Identical Sequences to LMP012436 proteins

Reference Database Accession Length Protein Name
GI:6981598 GenBank AAC53097.1 577 steroid sulfatase [Rattus norvegicus]
GI:6981598 SwissProt P15589.2 577 RecName: Full=Steryl-sulfatase; AltName: Full=Arylsulfatase C; Short=ASC; AltName: Full=Steroid sulfatase; AltName: Full=Steryl-sulfate sulfohydrolase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012436 proteins

Reference Database Accession Length Protein Name
GI:6981598 GenBank AAB09308.1 624 steroid sulfatase [Mus musculus]
GI:6981598 GenBank AAC53097.1 577 steroid sulfatase [Rattus norvegicus]
GI:6981598 SwissProt P15589.2 577 RecName: Full=Steryl-sulfatase; AltName: Full=Arylsulfatase C; Short=ASC; AltName: Full=Steroid sulfatase; AltName: Full=Steryl-sulfate sulfohydrolase; Flags: Precursor [Rattus norvegicus]