Gene/Proteome Database (LMPD)

LMPD ID
LMP012438
Gene ID
24804
Species
Rattus norvegicus (Rat)
Gene Name
synaptophysin
Gene Symbol
Syp
Synonyms
Syp1;
Alternate Names
synaptophysin; major synaptic vesicle protein p38;
Chromosome
X
Map Location
Xq13-q14
Summary
may play a role in synaptic vesicle organization and synaptic plasticity [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Syp

Proteins

synaptophysin
Refseq ID NP_036796
Protein GI 6981622
UniProt ID P07825
mRNA ID NM_012664
Length 307
MDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGGGGYGPQGDYGQQGYGQQGAPTSFSNQM

Gene Information

Entrez Gene ID
24804
Gene Name
synaptophysin
Gene Symbol
Syp
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0060076 IDA:BHF-UCL C excitatory synapse
GO:0030285 IBA:RefGenome C integral component of synaptic vesicle membrane
GO:0043229 IDA:RGD C intracellular organelle
GO:0043005 IDA:RGD C neuron projection
GO:0044306 IDA:RGD C neuron projection terminus
GO:0048786 IEA:Ensembl C presynaptic active zone
GO:0042734 IEA:Ensembl C presynaptic membrane
GO:0043234 IDA:RGD C protein complex
GO:0008021 IDA:ParkinsonsUK-UCL C synaptic vesicle
GO:0015485 IEA:Ensembl F cholesterol binding
GO:0032403 IPI:RGD F protein complex binding
GO:0019904 IPI:RGD F protein domain specific binding
GO:0017075 IDA:MGI F syntaxin-1 binding
GO:0005215 IEA:InterPro F transporter activity
GO:0071310 IEA:Ensembl P cellular response to organic substance
GO:0006897 IMP:UniProtKB P endocytosis
GO:0048169 IEA:Ensembl P regulation of long-term neuronal synaptic plasticity
GO:0048168 NAS:RGD P regulation of neuronal synaptic plasticity
GO:2000474 IDA:UniProtKB P regulation of opioid receptor signaling pathway
GO:0048172 IEA:Ensembl P regulation of short-term neuronal synaptic plasticity

Domain Information

InterPro Annotations

Accession Description
IPR008253 Marvel domain
IPR028714 Synaptophysin
IPR001285 Synaptophysin/synaptoporin

UniProt Annotations

Entry Information

Gene Name
synaptophysin
Protein Entry
SYPH_RAT
UniProt ID
P07825
Species
Rat

Comments

Comment Type Description
Domain The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
Function Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)
Interaction P33535:Oprm1; NbExp=8; IntAct=EBI-976085, EBI-4392569; Q9QWI6-2:Srcin1 (xeno); NbExp=2; IntAct=EBI-976085, EBI-775607;
Ptm Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Similarity Belongs to the synaptophysin/synaptobrevin family
Similarity Contains 1 MARVEL domain. {ECO:0000255|PROSITE- ProRule:PRU00581}.
Subcellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
Subunit Homohexamer or homotetramer. Interacts with SRCIN1 (By similarity)
Tissue Specificity Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Identical and Related Proteins

Unique RefSeq proteins for LMP012438 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981622 RefSeq NP_036796 307 synaptophysin

Identical Sequences to LMP012438 proteins

Reference Database Accession Length Protein Name
GI:6981622 GenBank AAA42196.1 307 synaptophysin [Rattus norvegicus]
GI:6981622 GenBank AAH99798.1 307 Syp protein [Rattus norvegicus]
GI:6981622 GenBank EDL83842.1 307 synaptophysin, isoform CRA_a [Rattus norvegicus]
GI:6981622 GenBank EDL83843.1 307 synaptophysin, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012438 proteins

Reference Database Accession Length Protein Name
GI:6981622 EMBL CAA29543.1 307 unnamed protein product [Rattus norvegicus]
GI:6981622 EMBL CAA29685.1 307 unnamed protein product [Rattus norvegicus]
GI:6981622 GenBank AAH99798.1 307 Syp protein [Rattus norvegicus]