Gene/Proteome Database (LMPD)

LMPD ID
LMP012443
Gene ID
24861
Species
Rattus norvegicus (Rat)
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A1
Gene Symbol
Ugt1a1
Synonyms
Ugt1; Udpgt; UDPGT 1-1;
Alternate Names
UDP-glucuronosyltransferase 1-1; B1; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1 family member 1; UDP glycosyltransferase 1 family, polypeptide A1;
Chromosome
9
Map Location
9q35-q36
EC Number
2.4.1.17
Summary
catalyzes the glucuronidation of bilirubin; plays a role in bilirubin conjugation and excretion [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ugt1a1

Proteins

UDP-glucuronosyltransferase 1-1 precursor
Refseq ID NP_036815
Protein GI 28849913
UniProt ID Q64550
mRNA ID NM_012683
Length 535
MSVVCRSSCSLLLLPCLLLCVLGPSASHAGKLLVIPIDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCSHLLHNAEFMASLEQSHFDALLTDPFLPCGSIVAQYLSLPAVYFLNALPCSLDLEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSPYGSLATEILQKEVTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKKALSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH
sig_peptide: 1..29 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2974 peptide sequence: MSVVCRSSCSLLLLPCLLLCVLGPSASHA mat_peptide: 30..535 product: UDP-glucuronosyltransferase 1-1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64550.1) calculated_mol_wt: 56707 peptide sequence: GKLLVIPIDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCSHLLHNAEFMASLEQSHFDALLTDPFLPCGSIVAQYLSLPAVYFLNALPCSLDLEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSPYGSLATEILQKEVTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKKALSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH

Gene Information

Entrez Gene ID
24861
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A1
Gene Symbol
Ugt1a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070069 IDA:RGD C cytochrome complex
GO:0005783 IDA:HGNC C endoplasmic reticulum
GO:0005887 IEA:Ensembl C integral component of plasma membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0019899 IDA:RGD F enzyme binding
GO:0004857 IEA:Ensembl F enzyme inhibitor activity
GO:0015020 IDA:RGD F glucuronosyltransferase activity
GO:0001972 IEA:Ensembl F retinoic acid binding
GO:0005496 IEA:Ensembl F steroid binding
GO:0006953 IEP:RGD P acute-phase response
GO:0006789 TAS:RGD P bilirubin conjugation
GO:0070980 IDA:RGD P biphenyl catabolic process
GO:0071361 IEP:RGD P cellular response to ethanol
GO:0071385 IEP:RGD P cellular response to glucocorticoid stimulus
GO:0032870 IEP:RGD P cellular response to hormone stimulus
GO:0051552 IEA:Ensembl P flavone metabolic process
GO:0052696 IEA:Ensembl P flavonoid glucuronidation
GO:0001889 IEP:RGD P liver development
GO:2001030 IEA:Ensembl P negative regulation of cellular glucuronidation
GO:0031100 IEP:RGD P organ regeneration
GO:0042493 IEP:RGD P response to drug
GO:0045471 IEP:RGD P response to ethanol
GO:0051384 IEP:RGD P response to glucocorticoid
GO:0032496 IEP:RGD P response to lipopolysaccharide
GO:0007584 IEP:RGD P response to nutrient
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0010033 IMP:RGD P response to organic substance
GO:0042594 IEP:RGD P response to starvation
GO:0048545 IEP:RGD P response to steroid hormone
GO:0052697 IEA:Ensembl P xenobiotic glucuronidation

KEGG Pathway Links

KEGG Pathway ID Description
ko00053 Ascorbate and aldarate metabolism
rno00053 Ascorbate and aldarate metabolism
M00129 Ascorbate biosynthesis, animals, glucose-1P => ascorbate
ko05204 Chemical carcinogenesis
rno05204 Chemical carcinogenesis
ko00982 Drug metabolism - cytochrome P450
rno00982 Drug metabolism - cytochrome P450
ko00983 Drug metabolism - other enzymes
rno00983 Drug metabolism - other enzymes
M00014 Glucuronate pathway (uronate pathway)
rno01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
rno00980 Metabolism of xenobiotics by cytochrome P450
ko00040 Pentose and glucuronate interconversions
rno00040 Pentose and glucuronate interconversions
ko00860 Porphyrin and chlorophyll metabolism
rno00860 Porphyrin and chlorophyll metabolism
ko00830 Retinol metabolism
rno00830 Retinol metabolism
ko00500 Starch and sucrose metabolism
rno00500 Starch and sucrose metabolism
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953258 Biological oxidations
5953256 Glucuronidation
5953717 Heme degradation
5953250 Metabolism
5953718 Metabolism of porphyrins
5953257 Phase II conjugation

Domain Information

InterPro Annotations

Accession Description
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A1
Protein Entry
UD11_RAT
UniProt ID
Q64550
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.; Name=1; IsoId=Q64550-1; Sequence=Displayed;
Catalytic Activity UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin.
Induction Overexpressed of two- to threefold upon clofibrate and dexamethasone administration
Similarity Belongs to the UDP-glycosyltransferase family
Subcellular Location Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein .
Subunit Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Identical and Related Proteins

Unique RefSeq proteins for LMP012443 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28849913 RefSeq NP_036815 535 UDP-glucuronosyltransferase 1-1 precursor

Identical Sequences to LMP012443 proteins

Reference Database Accession Length Protein Name
GI:28849913 GenBank AAL67852.1 535 UDP-glucuronosyltransferase 1A1 [Rattus norvegicus]
GI:28849913 GenBank AAR95629.1 535 UDP glycosyltransferase 1 family polypeptide A1 [Rattus norvegicus]
GI:28849913 GenBank EDL92105.1 535 rCG55639, isoform CRA_c [Rattus norvegicus]
GI:28849913 SwissProt Q64550.1 535 RecName: Full=UDP-glucuronosyltransferase 1-1; Short=UDPGT 1-1; Short=UGT1*1; Short=UGT1-01; Short=UGT1.1; AltName: Full=B1; AltName: Full=UDP-glucuronosyltransferase 1A1; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012443 proteins

Reference Database Accession Length Protein Name
GI:28849913 GenBank AAC52219.1 535 UDP-glucuronosyltransferase precursor [Rattus norvegicus]
GI:28849913 GenBank AAL67852.1 535 UDP-glucuronosyltransferase 1A1 [Rattus norvegicus]
GI:28849913 PRF - 535 UDP glucuronosyltransferase [Rattus norvegicus]