Gene/Proteome Database (LMPD)

LMPD ID
LMP012444
Gene ID
24873
Species
Rattus norvegicus (Rat)
Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor
Gene Symbol
Vdr
Synonyms
Nr1i1;
Alternate Names
vitamin D3 receptor; vitamin D receptor; 1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1; vitamin D (1,25-dihydroxyvitamin D3) receptor;
Chromosome
7
Map Location
7q36
Summary
binds vitamin D3; acts as a transcriptional regulator of the osteocalcin gene [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Vdr

Proteins

vitamin D3 receptor
Refseq ID NP_058754
Protein GI 8394529
UniProt ID P13053
mRNA ID NM_017058
Length 423
MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS

Gene Information

Entrez Gene ID
24873
Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor
Gene Symbol
Vdr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030315 IDA:RGD C T-tubule
GO:0005829 IDA:RGD C cytosol
GO:0001651 IDA:RGD C dense fibrillar component
GO:0000791 IDA:RGD C euchromatin
GO:0000792 IDA:RGD C heterochromatin
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005720 IDA:RGD C nuclear heterochromatin
GO:0016363 IDA:RGD C nuclear matrix
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:1902098 IDA:RGD F calcitriol binding
GO:0008434 IDA:RGD F calcitriol receptor activity
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0003700 TAS:RGD F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0005499 IDA:RGD F vitamin D binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0007568 IEP:RGD P aging
GO:0097190 IDA:RGD P apoptotic signaling pathway
GO:0071305 IEP:RGD P cellular response to vitamin D
GO:0007507 IEP:RGD P heart development
GO:0051924 IDA:RGD P regulation of calcium ion transport
GO:0006357 TAS:RGD P regulation of transcription from RNA polymerase II promoter
GO:0051592 IEP:RGD P response to calcium ion
GO:0032355 IEP:RGD P response to estradiol
GO:0070561 IDA:GOC P vitamin D receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko04961 Endocrine and other factor-regulated calcium reabsorption
rno04961 Endocrine and other factor-regulated calcium reabsorption
ko04978 Mineral absorption
rno04978 Mineral absorption
ko05152 Tuberculosis
rno05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR000324 Vitamin D receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor
Protein Entry
VDR_RAT
UniProt ID
P13053
Species
Rat

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus.
Subunit Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity (By similarity)
Tissue Specificity Detected in intestine and kidney

Identical and Related Proteins

Unique RefSeq proteins for LMP012444 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8394529 RefSeq NP_058754 423 vitamin D3 receptor

Identical Sequences to LMP012444 proteins

Reference Database Accession Length Protein Name
GI:8394529 GenBank AAA41089.1 423 1,25-dihydroxyvitamin D-3 receptor [Rattus norvegicus]
GI:8394529 SwissProt P13053.1 423 RecName: Full=Vitamin D3 receptor; Short=VDR; AltName: Full=1,25-dihydroxyvitamin D3 receptor; AltName: Full=Nuclear receptor subfamily 1 group I member 1 [Rattus norvegicus]

Related Sequences to LMP012444 proteins

Reference Database Accession Length Protein Name
GI:8394529 GenBank AAA41089.1 423 1,25-dihydroxyvitamin D-3 receptor [Rattus norvegicus]
GI:8394529 GenBank EDL87095.1 423 vitamin D receptor [Rattus norvegicus]
GI:8394529 SwissProt P13053.1 423 RecName: Full=Vitamin D3 receptor; Short=VDR; AltName: Full=1,25-dihydroxyvitamin D3 receptor; AltName: Full=Nuclear receptor subfamily 1 group I member 1 [Rattus norvegicus]