Gene/Proteome Database (LMPD)
LMPD ID
LMP012449
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, group XVI
Gene Symbol
Synonyms
HRSL3; Hrasls3; Hrev107;
Alternate Names
HRAS-like suppressor 3; H-rev 107 protein; HRAS like suppressor 3; group XVI phospholipase A2; group XVI phospholipase A1/A2; Hras-revertant gene 107 (expression down-regulated in HRAS-transformed rat 208F fibroblasts);
Chromosome
1
Map Location
1q43
EC Number
3.1.1.32
Summary
gene whose expression is suppressed by HRAS [RGD, Feb 2006]
Orthologs
Proteins
Gene Information
Entrez Gene ID
Gene Name
phospholipase A2, group XVI
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:RGD | C | cytoplasm |
| GO:0005783 | IEA:Ensembl | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:RGD | C | membrane |
| GO:0048471 | IEA:Ensembl | C | perinuclear region of cytoplasm |
| GO:0052740 | IEA:UniProtKB-EC | F | 1-acyl-2-lysophosphatidylserine acylhydrolase activity |
| GO:0008970 | IEA:UniProtKB-EC | F | phosphatidylcholine 1-acylhydrolase activity |
| GO:0052739 | IEA:UniProtKB-EC | F | phosphatidylserine 1-acylhydrolase activity |
| GO:0004623 | IEA:UniProtKB-EC | F | phospholipase A2 activity |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0045786 | IMP:RGD | P | negative regulation of cell cycle |
| GO:0008654 | IEA:Ensembl | P | phospholipid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00592 | alpha-Linolenic acid metabolism |
| rno00592 | alpha-Linolenic acid metabolism |
| ko00590 | Arachidonic acid metabolism |
| rno00590 | Arachidonic acid metabolism |
| ko00565 | Ether lipid metabolism |
| rno00565 | Ether lipid metabolism |
| ko00564 | Glycerophospholipid metabolism |
| rno00564 | Glycerophospholipid metabolism |
| ko00591 | Linoleic acid metabolism |
| rno00591 | Linoleic acid metabolism |
| rno01100 | Metabolic pathways |
| rno04014 | Ras signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954464 | Acyl chain remodelling of PC |
| 5954471 | Acyl chain remodelling of PE |
| 5954468 | Acyl chain remodelling of PI |
| 5954470 | Acyl chain remodelling of PS |
| 5953473 | Glycerophospholipid biosynthesis |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953474 | Phospholipid metabolism |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR007053 | LRAT-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. |
| Catalytic Activity | Phosphatidylcholine + H(2)O = 2- acylglycerophosphocholine + a carboxylate. |
| Function | Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O-acylation activity is hardly detectable. Also has weak lysophospholipase activity (By similarity) |
| Induction | Induced during preadipocyte differentiation into adipocytes |
| Similarity | Belongs to the H-rev107 family |
| Subcellular Location | Cytoplasm . Cytoplasm, perinuclear region . Membrane ; Single-pass membrane protein . |
| Subunit | Interacts with PPP2R1A; this interaction might decrease PP2A activity |
| Tissue Specificity | Specifically expressed in H-ras resistant fibroblasts. {ECO:0000269|PubMed:18614531, ECO:0000269|PubMed:8290259}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012449 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 126723733 | RefSeq | NP_058756 | 160 | HRAS-like suppressor 3 |
Identical Sequences to LMP012449 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:126723733 | DBBJ | BAH08634.1 | 160 | rat LRAT-like protein 3 [Rattus norvegicus] |
| GI:126723733 | GenBank | EDM12684.1 | 160 | rCG47447, isoform CRA_a [Rattus norvegicus] |
| GI:126723733 | GenBank | EDM12685.1 | 160 | rCG47447, isoform CRA_a [Rattus norvegicus] |
| GI:126723733 | SwissProt | P53817.2 | 160 | RecName: Full=HRAS-like suppressor 3; Short=HRSL3; AltName: Full=Group XVI phospholipase A1/A2; AltName: Full=H-rev 107 protein [Rattus norvegicus] |
Related Sequences to LMP012449 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:126723733 | DBBJ | BAH08634.1 | 160 | rat LRAT-like protein 3 [Rattus norvegicus] |
| GI:126723733 | GenBank | EDM12684.1 | 160 | rCG47447, isoform CRA_a [Rattus norvegicus] |
| GI:126723733 | SwissProt | P53817.2 | 160 | RecName: Full=HRAS-like suppressor 3; Short=HRSL3; AltName: Full=Group XVI phospholipase A1/A2; AltName: Full=H-rev 107 protein [Rattus norvegicus] |