Gene/Proteome Database (LMPD)

LMPD ID
LMP012450
Gene ID
24918
Species
Rattus norvegicus (Rat)
Gene Name
signal transducer and activator of transcription 5A
Gene Symbol
Stat5a
Synonyms
Stat5;
Alternate Names
signal transducer and activator of transcription 5A; mammary gland factor; signal transducer and activator of transcription 5;
Chromosome
10
Map Location
10q32.1
Summary
member of the STAT family of transcription factors; may mediate the biological actions of several interleukin factors (IL2, IL3, IL7) and growth hormones; may be associated with mammary gland function [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Stat5a

Proteins

signal transducer and activator of transcription 5A
Refseq ID NP_058760
Protein GI 8394373
UniProt ID Q62771
mRNA ID NM_017064
Length 793
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFVLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFGQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELVEKHQKTLQLLRKQQTIILDDELIQWKRGQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNRRSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDLDETMDVARHVEELLRRPMDSLDPRLSPPAGLFTSARSSLS

Gene Information

Entrez Gene ID
24918
Gene Name
signal transducer and activator of transcription 5A
Gene Symbol
Stat5a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005634 IDA:RGD C nucleus
GO:0005509 IEA:InterPro F calcium ion binding
GO:0003690 IDA:RGD F double-stranded DNA binding
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0003700 IDA:RGD F sequence-specific DNA binding transcription factor activity
GO:0004871 IEA:InterPro F signal transducer activity
GO:0007259 IDA:RGD P JAK-STAT cascade
GO:0007595 IEP:RGD P lactation
GO:0060056 IDA:RGD P mammary gland involution
GO:0048609 IEP:RGD P multicellular organismal reproductive process
GO:0038161 ISS:UniProtKB P prolactin signaling pathway
GO:0006355 TAS:RGD P regulation of transcription, DNA-templated
GO:0045471 IEP:RGD P response to ethanol
GO:0031667 IEP:RGD P response to nutrient levels
GO:0006366 IDA:RGD P transcription from RNA polymerase II promoter

KEGG Pathway Links

KEGG Pathway ID Description
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
ko05220 Chronic myeloid leukemia
rno05220 Chronic myeloid leukemia
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko05166 HTLV-I infection
rno05166 HTLV-I infection
rno05161 Hepatitis B
ko04630 Jak-STAT signaling pathway
rno04630 Jak-STAT signaling pathway
ko05162 Measles
rno05162 Measles
rno05200 Pathways in cancer
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko05203 Viral carcinogenesis
rno05203 Viral carcinogenesis

Domain Information

InterPro Annotations

Accession Description
IPR011992 EF-hand domain pair
IPR000980 SH2 domain
IPR013801 STAT transcription factor, DNA-binding
IPR012345 STAT transcription factor, DNA-binding, subdomain
IPR013800 STAT transcription factor, all-alpha
IPR015988 STAT transcription factor, coiled coil
IPR013799 STAT transcription factor, protein interaction
IPR001217 Transcription factor STAT
IPR008967 p53-like transcription factor, DNA-binding

UniProt Annotations

Entry Information

Gene Name
signal transducer and activator of transcription 5A
Protein Entry
STA5A_RAT
UniProt ID
Q62771
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Stat5A1; IsoId=Q62771-1; Sequence=Displayed; Name=Stat5A2; IsoId=Q62771-2; Sequence=VSP_006288, VSP_006289;
Developmental Stage Detected both in virgin rats and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases at the onset of lactation and remains lows throughout lactation.
Function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation
Ptm ISGylated
Ptm Tyrosine phosphorylated in response to IL2, IL3, IL7, IL15, KITLG/SCF, CSF2/GMCSF, GH1, PRL, EPO and THPO. Tyrosine phosphorylated in response to signaling via activated FLT3 and KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Alternatively, can be phosphorylated by JAK2 at Tyr-694. Tyrosine phosphorylation is required for DNA- binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway (By similarity)
Similarity Belongs to the transcription factor STAT family
Similarity Contains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular Location Cytoplasm . Nucleus . Note=Mostly cytoplasmic during pregnancy, whereas it becomes predominantly nuclear during early lactation. It is translocated into the nucleus in response to phosphorylation (By similarity)
Subunit Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4 (By similarity)
Tissue Specificity Expressed in heart, lung, and weakly in muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP012450 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8394373 RefSeq NP_058760 793 signal transducer and activator of transcription 5A

Identical Sequences to LMP012450 proteins

Reference Database Accession Length Protein Name
GI:8394373 GenBank AAA98843.1 793 signal transducer and regulator of transcription 5a1 [Rattus norvegicus]
GI:8394373 SwissProt Q62771.1 793 RecName: Full=Signal transducer and activator of transcription 5A; AltName: Full=Mammary gland factor [Rattus norvegicus]

Related Sequences to LMP012450 proteins

Reference Database Accession Length Protein Name
GI:8394373 GenBank AAA98843.1 793 signal transducer and regulator of transcription 5a1 [Rattus norvegicus]
GI:8394373 GenBank EDM06067.1 793 rCG35111 [Rattus norvegicus]
GI:8394373 SwissProt Q62771.1 793 RecName: Full=Signal transducer and activator of transcription 5A; AltName: Full=Mammary gland factor [Rattus norvegicus]