Gene/Proteome Database (LMPD)
LMPD ID
LMP012451
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin E receptor 3 (subtype EP3)
Gene Symbol
Synonyms
EP3; Rep3; rEP3a; rEP3b;
Alternate Names
prostaglandin E2 receptor EP3 subtype; prostanoid EP3 receptor; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype;
Chromosome
2
Map Location
2q44-q45
Summary
receptor that binds prostaglandins E2 and E1; may be involved in natriuresis [RGD, Feb 2006]
Orthologs
Proteins
| prostaglandin E2 receptor EP3 subtype | |
|---|---|
| Refseq ID | NP_036836 |
| Protein GI | 6981434 |
| UniProt ID | P34980 |
| mRNA ID | NM_012704 |
| Length | 362 |
| MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMMNNLKRSFIAIPASLSMRISSPREG | |
Gene Information
Entrez Gene ID
Gene Name
prostaglandin E receptor 3 (subtype EP3)
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0004957 | IEA:InterPro | F | prostaglandin E receptor activity |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04020 | Calcium signaling pathway |
| rno04020 | Calcium signaling pathway |
| ko04024 | cAMP signaling pathway |
| rno04024 | cAMP signaling pathway |
| ko04080 | Neuroactive ligand-receptor interaction |
| rno04080 | Neuroactive ligand-receptor interaction |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954122 | Class A/1 (Rhodopsin-like receptors) |
| 5954202 | Eicosanoid ligand-binding receptors |
| 5954152 | G alpha (i) signalling events |
| 5953642 | GPCR downstream signaling |
| 5953758 | GPCR ligand binding |
| 5954201 | Prostanoid ligand receptors |
| 5953391 | Signaling by GPCR |
| 5953381 | Signal Transduction |
Domain Information
UniProt Annotations
Entry Information
Gene Name
prostaglandin E receptor 3 (subtype EP3)
Protein Entry
PE2R3_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist. Isoforms have identical ligand binding properties but different coupling properties with G proteins: isoform Alpha and isoform Beta couple to G(i) proteins, whereas isoform Gamma couples to multiple G proteins, G(i) and G(s).; Name=Alpha; IsoId=P34980-1; Sequence=Displayed; Name=Beta; IsoId=P34980-2; Sequence=VSP_001949; Name=Gamma; IsoId=P34980-3; Sequence=VSP_001950; |
| Function | Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. The various forms can interact with different second messenger systems (By similarity) |
| Similarity | Belongs to the G-protein coupled receptor 1 family |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Principally expressed in the tubules of the renal medulla. Specific expression is seen in medullary and cortical thick ascending limbs; lower levels are detected in cortical and inner medullary collecting ducts. Not detected significantly in the glomeruli. In the brain, expressed in all types of glial cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012451 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6981434 | RefSeq | NP_036836 | 362 | prostaglandin E2 receptor EP3 subtype |
Identical Sequences to LMP012451 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981434 | DBBJ | BAA06236.1 | 362 | prostaglandin E receptor EP3-beta subtype [Rattus norvegicus] |
| GI:6981434 | EMBL | CAA56432.1 | 362 | EP3B receptor [Rattus norvegicus] |
| GI:6981434 | GenBank | EDL82566.1 | 362 | prostaglandin E receptor 3 (subtype EP3), isoform CRA_c [Rattus norvegicus] |
Related Sequences to LMP012451 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981434 | DBBJ | BAA06236.1 | 362 | prostaglandin E receptor EP3-beta subtype [Rattus norvegicus] |
| GI:6981434 | EMBL | CAA56432.1 | 362 | EP3B receptor [Rattus norvegicus] |
| GI:6981434 | GenBank | EDL82566.1 | 362 | prostaglandin E receptor 3 (subtype EP3), isoform CRA_c [Rattus norvegicus] |