Gene/Proteome Database (LMPD)

LMPD ID
LMP012455
Gene ID
25014
Species
Rattus norvegicus (Rat)
Gene Name
acetyl-CoA acetyltransferase 1
Gene Symbol
Acat1
Synonyms
RATACAL;
Alternate Names
acetyl-CoA acetyltransferase, mitochondrial; acetoacetyl-CoA thiolase; acetyl-coenzyme A acetyltransferase 1; acetyl-Co A acetyltransferase 1 mitochondrial;
Chromosome
8
Map Location
8q24.1
EC Number
2.3.1.9
Summary
catalyzes the conversion of 2 acetyl-CoA molecules to acetoacetyl-CoA plus CoA [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acat1

Proteins

acetyl-CoA acetyltransferase, mitochondrial precursor
Refseq ID NP_058771
Protein GI 401461805
UniProt ID P17764
mRNA ID NM_017075
Length 424
MAALAVLHGVVRRPLLRGLLQEVRCLGRSYASKPTLNDVVIVSATRTPIGSFLGSLASQPATKLGTIAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPIATPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKLSISREEQDKYAIGSYTRSKEAWDAGKFANEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAAVVLMTAEAAQRLKVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNVHGGAVSLGHPIGMSGARIVVHLAHALKQGEFGLASICNGGGGASAVLIEKL
transit_peptide: 1..30 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P17764.1) calculated_mol_wt: 3348 peptide sequence: MAALAVLHGVVRRPLLRGLLQEVRCLGRSY mat_peptide: 31..424 product: Acetyl-CoA acetyltransferase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P17764.1) calculated_mol_wt: 41365 peptide sequence: ASKPTLNDVVIVSATRTPIGSFLGSLASQPATKLGTIAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPIATPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKLSISREEQDKYAIGSYTRSKEAWDAGKFANEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAAVVLMTAEAAQRLKVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNVHGGAVSLGHPIGMSGARIVVHLAHALKQGEFGLASICNGGGGASAVLIEKL

Gene Information

Entrez Gene ID
25014
Gene Name
acetyl-CoA acetyltransferase 1
Gene Symbol
Acat1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005743 IEA:Ensembl C mitochondrial inner membrane
GO:0005759 IDA:RGD C mitochondrial matrix
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0003985 IDA:RGD F acetyl-CoA C-acetyltransferase activity
GO:0050662 IPI:RGD F coenzyme binding
GO:0019899 IPI:RGD F enzyme binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0060612 IEP:RGD P adipose tissue development
GO:0007420 IEP:RGD P brain development
GO:0001889 IEP:RGD P liver development
GO:0072229 IEP:RGD P metanephric proximal convoluted tubule development
GO:0051260 IDA:RGD P protein homooligomerization
GO:0009725 IEP:RGD P response to hormone
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0042594 IEP:RGD P response to starvation

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
ko01200 Carbon metabolism
rno01200 Carbon metabolism
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko00630 Glyoxylate and dicarboxylate metabolism
rno00630 Glyoxylate and dicarboxylate metabolism
ko00310 Lysine degradation
rno00310 Lysine degradation
rno01100 Metabolic pathways
ko00640 Propanoate metabolism
rno00640 Propanoate metabolism
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism
ko00072 Synthesis and degradation of ketone bodies
rno00072 Synthesis and degradation of ketone bodies
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953282 Branched-chain amino acid catabolism
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953366 Ketone body metabolism
5953250 Metabolism
5953272 Metabolism of amino acids and derivatives
5953289 Metabolism of lipids and lipoproteins
5953365 Synthesis of Ketone Bodies
5953367 Utilization of Ketone Bodies

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acetyltransferase 1
Protein Entry
THIL_RAT
UniProt ID
P17764
Species
Rat

Comments

Comment Type Description
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA
Enzyme Regulation Activated by potassium ions, but not sodium ions
Function Plays a major role in ketone body metabolism.
Ptm Succinylation at Lys-265, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity)
Similarity Belongs to the thiolase family
Subcellular Location Mitochondrion.
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012455 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
401461805 RefSeq NP_058771 424 acetyl-CoA acetyltransferase, mitochondrial precursor

Identical Sequences to LMP012455 proteins

Reference Database Accession Length Protein Name
GI:401461805 DBBJ BAA03016.1 424 mitochondrial acetoacetyl-CoA thiolase [Rattus norvegicus]
GI:401461805 GenBank EDL95520.1 424 acetyl-coenzyme A acetyltransferase 1, isoform CRA_b [Rattus norvegicus]
GI:401461805 SwissProt P17764.1 424 RecName: Full=Acetyl-CoA acetyltransferase, mitochondrial; AltName: Full=Acetoacetyl-CoA thiolase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012455 proteins

Reference Database Accession Length Protein Name
GI:401461805 DBBJ BAA03016.1 424 mitochondrial acetoacetyl-CoA thiolase [Rattus norvegicus]
GI:401461805 GenBank EDL95520.1 424 acetyl-coenzyme A acetyltransferase 1, isoform CRA_b [Rattus norvegicus]
GI:401461805 SwissProt P17764.1 424 RecName: Full=Acetyl-CoA acetyltransferase, mitochondrial; AltName: Full=Acetoacetyl-CoA thiolase; Flags: Precursor [Rattus norvegicus]