Gene/Proteome Database (LMPD)

LMPD ID
LMP012462
Gene ID
25055
Species
Rattus norvegicus (Rat)
Gene Name
lipase A, lysosomal acid, cholesterol esterase
Gene Symbol
Lipa
Synonyms
LAL; Lip1; Chole; Chole2;
Alternate Names
lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase; cholesteryl esterase; lysosomal acid lipase 1; lysosomal acid lipase A; pancreatic cholesterol esterase; acid cholesteryl ester hydrolase; Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25;
Chromosome
1
Map Location
1q52
Summary
hydrolase that is involved in intracellular degradation of cholesteryl esters and triglycerides; mutation in gene causes Wolman's disease [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lipa

Proteins

lysosomal acid lipase/cholesteryl ester hydrolase precursor
Refseq ID NP_036864
Protein GI 77917572
UniProt ID Q6IMY6
mRNA ID NM_012732
Length 397
MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWRLYNEVVSLMKKYQ
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2532 peptide sequence: MQLLGRVICFVVGILLSGGPTGTIS

Gene Information

Entrez Gene ID
25055
Gene Name
lipase A, lysosomal acid, cholesterol esterase
Gene Symbol
Lipa
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016298 IEA:Ensembl F lipase activity
GO:0004771 IEA:Ensembl F sterol esterase activity
GO:0000902 IEA:Ensembl P cell morphogenesis
GO:0008283 IEA:Ensembl P cell proliferation
GO:0001816 IEA:Ensembl P cytokine production
GO:0048873 IEA:Ensembl P homeostasis of number of cells within a tissue
GO:0006954 IEA:Ensembl P inflammatory response
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0030324 IEA:Ensembl P lung development
GO:0048771 IEA:Ensembl P tissue remodeling

KEGG Pathway Links

KEGG Pathway ID Description
ko04142 Lysosome
rno04142 Lysosome
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1
IPR025483 Lipase, eukaryotic
IPR006693 Partial AB-hydrolase lipase domain

UniProt Annotations

Entry Information

Gene Name
lipase A, lysosomal acid, cholesterol esterase
Protein Entry
Q6IMY6_RAT
UniProt ID
Q6IMY6
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012462 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
77917572 RefSeq NP_036864 397 lysosomal acid lipase/cholesteryl ester hydrolase precursor

Identical Sequences to LMP012462 proteins

Reference Database Accession Length Protein Name
GI:77917572 GenBank EDM13163.1 397 lysosomal acid lipase 1, isoform CRA_a [Rattus norvegicus]
GI:77917572 GenBank EDM13164.1 397 lysosomal acid lipase 1, isoform CRA_a [Rattus norvegicus]
GI:77917572 RefSeq XP_006231337.1 397 PREDICTED: lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [Rattus norvegicus]
GI:77917572 RefSeq XP_008758543.1 397 PREDICTED: lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [Rattus norvegicus]

Related Sequences to LMP012462 proteins

Reference Database Accession Length Protein Name
GI:77917572 GenBank AAH72532.1 397 Lipase A, lysosomal acid, cholesterol esterase [Rattus norvegicus]
GI:77917572 GenBank EDM13161.1 397 lysosomal acid lipase 1, isoform CRA_a [Rattus norvegicus]
GI:77917572 GenBank EDM13162.1 397 lysosomal acid lipase 1, isoform CRA_a [Rattus norvegicus]