Gene/Proteome Database (LMPD)

LMPD ID
LMP012463
Gene ID
25056
Species
Rattus norvegicus (Rat)
Gene Name
retinol binding protein 1, cellular
Gene Symbol
Rbp1
Alternate Names
retinol-binding protein 1; CRBP; CRBP-I; cellular retinol-binding protein I;
Chromosome
8
Map Location
8q31
Summary
binds and transports retinol; plays a role in vitamin A metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Rbp1

Proteins

retinol-binding protein 1
Refseq ID NP_036865
Protein GI 6981464
UniProt ID P02696
mRNA ID NM_012733
Length 135
MPVDFNGYWKMLSNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRAEGVTCKQVFKKVH

Gene Information

Entrez Gene ID
25056
Gene Name
retinol binding protein 1, cellular
Gene Symbol
Rbp1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044297 IDA:RGD C cell body
GO:0005829 IDA:RGD C cytosol
GO:0016918 IEA:UniProtKB-KW F retinal binding
GO:0019841 IDA:RGD F retinol binding
GO:0005215 IEA:InterPro F transporter activity
GO:0030852 IEA:Ensembl P regulation of granulocyte differentiation
GO:0033189 IEA:Ensembl P response to vitamin A
GO:0002138 IEP:RGD P retinoic acid biosynthetic process
GO:0042572 IDA:RGD P retinol metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5953253 Disease
5953382 Diseases associated with visual transduction
5954579 Retinoid cycle disease events
5954392 Retinoid metabolism and transport
5953381 Signal Transduction
5953384 The canonical retinoid cycle in rods (twilight vision)
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
retinol binding protein 1, cellular
Protein Entry
RET1_RAT
UniProt ID
P02696
Species
Rat

Comments

Comment Type Description
Domain Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Function Intracellular transport of retinol.
Similarity Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP012463 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981464 RefSeq NP_036865 135 retinol-binding protein 1

Identical Sequences to LMP012463 proteins

Reference Database Accession Length Protein Name
GI:6981464 GenBank AAE19310.1 135 Sequence 8 from patent US 5844081
GI:6981464 GenBank AAE27634.1 135 Sequence 4 from patent US 5955305
GI:6981464 PDB 1JBH 135 Chain A, Solution Structure Of Cellular Retinol Binding Protein Type- I In The Ligand-Free State
GI:6981464 PDB 1KGL 135 Chain A, Solution Structure Of Cellular Retinol Binding Protein Type- I In Complex With All-Trans-Retinol

Related Sequences to LMP012463 proteins

Reference Database Accession Length Protein Name
GI:6981464 GenBank AAA40962.1 135 cytosolic retinol-binding protein [Rattus norvegicus]
GI:6981464 GenBank AAE27634.1 135 Sequence 4 from patent US 5955305
GI:6981464 SwissProt P02696.2 135 RecName: Full=Retinol-binding protein 1; AltName: Full=Cellular retinol-binding protein; Short=CRBP; AltName: Full=Cellular retinol-binding protein I; Short=CRBP-I [Rattus norvegicus]