Gene/Proteome Database (LMPD)

LMPD ID
LMP012465
Gene ID
25062
Species
Rattus norvegicus (Rat)
Gene Name
glycerol-3-phosphate dehydrogenase 2, mitochondrial
Gene Symbol
Gpd2
Synonyms
mtGPDH;
Alternate Names
glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; GPDH-M; Glycerol-3-phosophate dehydrogenase 2 (mitochondrial); mtGPDH gene, promoter region and alternative transcripts;
Chromosome
3
Map Location
3q21-q23
EC Number
1.1.5.3
Summary
FAD-linked glycerol-3-phosphate dehydrogenase; expression in liver is induced by thyroid hormone [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gpd2

Proteins

glycerol-3-phosphate dehydrogenase, mitochondrial precursor
Refseq ID NP_036868
Protein GI 6980978
UniProt ID P35571
mRNA ID NM_012736
Length 727
MAFQKVVKGTILMGGGALATVLGLSQFAHYRRKQVSLAYVEAATCFSEPVNREPPSREAQLMTLQNTSEFDILVIGGGATGCGCALDAVTRGLKTALVERNDFASGTSSRSTKLIHGGVRYLQKAITNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSHCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGHEFNVRAKCVINATGPFTDSVRKMDDNDVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDSPTDVTHHPIPSEDDINFILNEVRNYLSCDVEVRRGDVLAAWSGIRPLVTDPKSANTQSISRNHVVEVSDSGLITIAGGKWTTYRSMAEDTVNKAVKLHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFDVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPKIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPPDIDRYKKRFHMFDEDEKGFITIVDVQRVLESINVQMDEDTLHEILCEVDLNKNGQVELHEFLQLMSAVHTGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL
transit_peptide: 1..42 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P35571.1) calculated_mol_wt: 4511 peptide sequence: MAFQKVVKGTILMGGGALATVLGLSQFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P35571.1) calculated_mol_wt: 76480 peptide sequence: ATCFSEPVNREPPSREAQLMTLQNTSEFDILVIGGGATGCGCALDAVTRGLKTALVERNDFASGTSSRSTKLIHGGVRYLQKAITNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSHCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGHEFNVRAKCVINATGPFTDSVRKMDDNDVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDSPTDVTHHPIPSEDDINFILNEVRNYLSCDVEVRRGDVLAAWSGIRPLVTDPKSANTQSISRNHVVEVSDSGLITIAGGKWTTYRSMAEDTVNKAVKLHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFDVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPKIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPPDIDRYKKRFHMFDEDEKGFITIVDVQRVLESINVQMDEDTLHEILCEVDLNKNGQVELHEFLQLMSAVHTGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL

Gene Information

Entrez Gene ID
25062
Gene Name
glycerol-3-phosphate dehydrogenase 2, mitochondrial
Gene Symbol
Gpd2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009331 IEA:InterPro C glycerol-3-phosphate dehydrogenase complex
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004367 IDA:RGD F glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0052591 IEA:UniProtKB-EC F sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
GO:0006734 IDA:RGD P NADH metabolic process
GO:0019563 IEA:UniProtKB-UniPathway P glycerol catabolic process
GO:0006072 IDA:RGD P glycerol-3-phosphate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins

Domain Information

InterPro Annotations

Accession Description
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR006076 FAD dependent oxidoreductase
IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate dehydrogenase 2, mitochondrial
Protein Entry
GPDM_RAT
UniProt ID
P35571
Species
Rat

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Enzyme Regulation Calcium-binding enhance the activity of the enzyme.
Pathway Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.
Similarity Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular Location Mitochondrion.

Identical and Related Proteins

Unique RefSeq proteins for LMP012465 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6980978 RefSeq NP_036868 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor

Identical Sequences to LMP012465 proteins

Reference Database Accession Length Protein Name
GI:6980978 EMBL CAA55329.1 727 glycerol-3-phosphate dehydrogenase [Rattus norvegicus]
GI:6980978 GenBank AAB60443.1 727 glycerolphosphate dehydrogenase [Rattus norvegicus]
GI:6980978 GenBank AAH83565.1 727 Gpd2 protein [Rattus norvegicus]
GI:6980978 SwissProt P35571.1 727 RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012465 proteins

Reference Database Accession Length Protein Name
GI:6980978 GenBank AAB60443.1 727 glycerolphosphate dehydrogenase [Rattus norvegicus]
GI:6980978 GenBank AAH83565.1 727 Gpd2 protein [Rattus norvegicus]
GI:6980978 SwissProt P35571.1 727 RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; Flags: Precursor [Rattus norvegicus]