Gene/Proteome Database (LMPD)

LMPD ID
LMP012466
Gene ID
25080
Species
Rattus norvegicus (Rat)
Gene Name
apolipoprotein A-IV
Gene Symbol
Apoa4
Synonyms
apoAIV; Apo-AIV; ApoA-IV;
Alternate Names
apolipoprotein A-IV; apolipoprotein A4;
Chromosome
8
Map Location
8q22
Summary
may play a role in lipid transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Apoa4

Proteins

apolipoprotein A-IV precursor
Refseq ID NP_036869
Protein GI 8392909
UniProt ID P02651
mRNA ID NM_012737
Length 391
MFLKAVVLTVALVAITGTQAEVTSDQVANVMWDYFTQLSNNAKEAVEQLQKTDVTQQLNTLFQDKLGNINTYADDLQNKLVPFAVQLSGHLTKETERVREEIQKELEDLRANMMPHANKVSQMFGDNVQKLQEHLRPYATDLQAQINAQTQDMKRQLTPYIQRMQTTIQDNVENLQSSMVPFANELKEKFNQNMEGLKGQLTPRANELKATIDQNLEDLRSRLAPLAEGVQEKLNHQMEGLAFQMKKNAEELHTKVSTNIDQLQKNLAPLVEDVQSKLKGNTEGLQKSLEDLNKQLDQQVEVFRRAVEPLGDKFNMALVQQMEKFRQQLGSDSGDVESHLSFLEKNLREKVSSFMSTLQKKGSPDQPLALPLPEQVQEQVQEQVQPKPLES
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2047 peptide sequence: MFLKAVVLTVALVAITGTQA mat_peptide: 21..391 product: apolipoprotein A-IV calculated_mol_wt: 42437 peptide sequence: EVTSDQVANVMWDYFTQLSNNAKEAVEQLQKTDVTQQLNTLFQDKLGNINTYADDLQNKLVPFAVQLSGHLTKETERVREEIQKELEDLRANMMPHANKVSQMFGDNVQKLQEHLRPYATDLQAQINAQTQDMKRQLTPYIQRMQTTIQDNVENLQSSMVPFANELKEKFNQNMEGLKGQLTPRANELKATIDQNLEDLRSRLAPLAEGVQEKLNHQMEGLAFQMKKNAEELHTKVSTNIDQLQKNLAPLVEDVQSKLKGNTEGLQKSLEDLNKQLDQQVEVFRRAVEPLGDKFNMALVQQMEKFRQQLGSDSGDVESHLSFLEKNLREKVSSFMSTLQKKGSPDQPLALPLPEQVQEQVQEQVQPKPLES

Gene Information

Entrez Gene ID
25080
Gene Name
apolipoprotein A-IV
Gene Symbol
Apoa4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042627 IDA:RGD C chylomicron
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0008289 IEA:InterPro F lipid binding
GO:0006869 TAS:RGD P lipid transport
GO:0042157 IEA:InterPro P lipoprotein metabolic process
GO:0014012 IEP:RGD P peripheral nervous system axon regeneration
GO:0032094 TAS:RGD P response to food
GO:0034014 IEP:RGD P response to triglyceride

KEGG Pathway Links

KEGG Pathway ID Description
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko04977 Vitamin digestion and absorption
rno04977 Vitamin digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein A-IV
Protein Entry
APOA4_RAT
UniProt ID
P02651
Species
Rat

Comments

Comment Type Description
Domain Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11- mers) occurring in this sequence are predicted to be highly alpha- helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
Function May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Similarity Belongs to the apolipoprotein A1/A4/E family
Subcellular Location Secreted.
Subunit Homodimer
Tissue Specificity Secreted in plasma.

Identical and Related Proteins

Unique RefSeq proteins for LMP012466 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8392909 RefSeq NP_036869 391 apolipoprotein A-IV precursor

Identical Sequences to LMP012466 proteins

Reference Database Accession Length Protein Name
GI:8392909 GenBank AAA85909.1 391 apolipoprotein A-IV prepeptide [Rattus norvegicus]

Related Sequences to LMP012466 proteins

Reference Database Accession Length Protein Name
GI:8392909 GenBank AAA85909.1 391 apolipoprotein A-IV prepeptide [Rattus norvegicus]
GI:8392909 GenBank EDL95397.1 391 apolipoprotein A-IV [Rattus norvegicus]
GI:8392909 SwissProt P02651.2 391 RecName: Full=Apolipoprotein A-IV; Short=Apo-AIV; Short=ApoA-IV; AltName: Full=Apolipoprotein A4; Flags: Precursor [Rattus norvegicus]