Gene/Proteome Database (LMPD)
LMPD ID
LMP012469
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase D1
Gene Symbol
Synonyms
Plda; Pldb; Pld1a; Pld1b;
Alternate Names
phospholipase D1; PLD 1; rPLD1; choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1; Phoshpolipase D gene 1 probably with two splicing variants A and B; phospholipase D gene 1, probably with two splicing variants A and B;
Chromosome
2
Map Location
2q23.3-q24
EC Number
3.1.4.4
Summary
ubiquitous enzyme that hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline [RGD, Feb 2006]
Orthologs
Proteins
| phospholipase D1 | |
|---|---|
| Refseq ID | NP_112254 |
| Protein GI | 25742819 |
| UniProt ID | P70496 |
| mRNA ID | NM_030992 |
| Length | 1036 |
| MSLRSEARVNTSTLQKIAADMRNLIENLDTRELHFEGEEVEYDASPGDPTAQEACIPFSSIYNTQGFKEPNIQIYLSGCPVKAQVLEVERFTSTSRMPSVNLYTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPIPTKRHTFRRQNVKEEPREMPSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLSFIHDLGPKGLEGMIMKRSGGHRIPGVNCCGHGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFRIKVGKKETETKYGLRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTDFLKDHRFGSYAAVHENILAKWYVNAKGYFEDIANAMEGATEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGQSLGSLTAASVESMESLSLKDKHQSHKNEPVLKSVNDTDMKLKGIGKSRKFSKFSLYRQLHRRNLHNSDSISSVDSASNTGSIRSVQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIGSVVHGKAARDVARHFIQRWNFTKIMKPKYRSLSYPFLLPKSQATAHELRYQVPGAVHAKAQLLRSAADWSAGIKXHEESIHAAYTHVIENSKHYIYIENQFFISCADDKVVFNKVGNAIAQRILKAHREGQRYRVYIVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGESSILEQLKPELGNKWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDRQTVPSVMDGKEYQAGRFAQGLRLECFRLVLGYLSDPSEDIQDPVSDKFFKEIWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPILAKEDRLRAEEELRKIRGFLVQFPFYFLSEENLLPSVGTKEAIVPMEVWT | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005768 | IEA:UniProtKB-KW | C | endosome |
| GO:0031985 | IDA:RGD | C | Golgi cisterna |
| GO:0043231 | IDA:RGD | C | intracellular membrane-bounded organelle |
| GO:0030027 | IDA:RGD | C | lamellipodium |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0031982 | IDA:RGD | C | vesicle |
| GO:0070290 | IEA:UniProtKB-EC | F | N-acylphosphatidylethanolamine-specific phospholipase D activity |
| GO:0035091 | IEA:InterPro | F | phosphatidylinositol binding |
| GO:0004630 | IDA:RGD | F | phospholipase D activity |
| GO:0006654 | IMP:MGI | P | phosphatidic acid biosynthetic process |
| GO:0008654 | IMP:MGI | P | phospholipid biosynthetic process |
| GO:0009395 | IMP:RGD | P | phospholipid catabolic process |
| GO:0030335 | IMP:RGD | P | positive regulation of cell migration |
| GO:0043434 | IMP:RGD | P | response to peptide hormone |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04024 | cAMP signaling pathway |
| rno04024 | cAMP signaling pathway |
| ko04144 | Endocytosis |
| rno04144 | Endocytosis |
| ko00565 | Ether lipid metabolism |
| rno00565 | Ether lipid metabolism |
| ko04666 | Fc gamma R-mediated phagocytosis |
| rno04666 | Fc gamma R-mediated phagocytosis |
| ko04724 | Glutamatergic synapse |
| rno04724 | Glutamatergic synapse |
| ko00564 | Glycerophospholipid metabolism |
| rno00564 | Glycerophospholipid metabolism |
| ko04912 | GnRH signaling pathway |
| rno04912 | GnRH signaling pathway |
| rno01100 | Metabolic pathways |
| ko05212 | Pancreatic cancer |
| rno05212 | Pancreatic cancer |
| rno04014 | Ras signaling pathway |
REACTOME Pathway Links
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=PLD1A; IsoId=P70496-1; Sequence=Displayed; Name=PLD1B; IsoId=P70496-2; Sequence=VSP_005024; Name=PLD1C; IsoId=P70496-3; Sequence=VSP_005025, VSP_005026; |
| Catalytic Activity | A phosphatidylcholine + H(2)O = choline + a phosphatidate. |
| Enzyme Regulation | Stimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42 |
| Function | Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) |
| Ptm | It is uncertain whether palmitoylation is on Cys-240 and/or Cys-241. Palmitoylation is required prior to phosphorylation |
| Ptm | Phosphorylated on serine and threonine residues |
| Similarity | Belongs to the phospholipase D family |
| Similarity | Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}. |
| Similarity | Contains 1 PX (phox homology) domain |
| Similarity | Contains 2 PLD phosphodiesterase domains |
| Subcellular Location | Cytoplasm, perinuclear region . Endoplasmic reticulum membrane ; Lipid-anchor {ECO:0000250}. Golgi apparatus membrane ; Lipid- anchor {ECO:0000250}. Late endosome membrane ; Lipid- anchor . Note=Membrane-associated. |
| Subunit | Interacts with PIP5K1B |
Identical and Related Proteins
Unique RefSeq proteins for LMP012469 (as displayed in Record Overview)
Identical Sequences to LMP012469 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:25742819 | GenBank | AAB86910.1 | 1036 | phospholipase D [Rattus norvegicus] |
| GI:25742819 | GenBank | AFL05443.1 | 1036 | Sequence 2 from patent US 8168177 |
| GI:25742819 | GenBank | AFX02570.1 | 1036 | Sequence 2 from patent US 8278263 |
Related Sequences to LMP012469 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:25742819 | GenBank | AAB86910.1 | 1036 | phospholipase D [Rattus norvegicus] |
| GI:25742819 | GenBank | AFL05443.1 | 1036 | Sequence 2 from patent US 8168177 |
| GI:25742819 | GenBank | AFX02570.1 | 1036 | Sequence 2 from patent US 8278263 |