Gene/Proteome Database (LMPD)

LMPD ID
LMP012470
Gene ID
25097
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase D2
Gene Symbol
Pld2
Synonyms
Pldc;
Alternate Names
phospholipase D2; PLD 2; PLD1C; rPLD2; choline phosphatase 2; phospholipase D gene 2; phosphatidylcholine-hydrolyzing phospholipase D2;
Chromosome
10
Map Location
10q23.3-q24
EC Number
3.1.4.4
Summary
catalyzes hydrolysis of phosphatidylcholine (PC) to phosphatidic acid and choline; involved in important cellular processes such as signal transduction, membrane trafficking, and mitosis regulation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pld2

Proteins

phospholipase D2
Refseq ID NP_150641
Protein GI 31377516
UniProt ID P70498
mRNA ID NM_033299
Length 933
MTVTQTDLFPYGDYLNSSQLHMEPDEVDTLKEGEDPADRMHPFLAIYDLQPLRAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLPLARFAAAHSPAREAANENIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFTCCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTEARYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGPGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAREEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQAVAFLGGLDLAYGRWDDVQYRLTDLGDPSESADSQTPTPGSDPAATPDLSHNHFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTIKARYKIPQYPYLLPKSASTANHLPFIIPGAQCATVQVLRSVDRWSAGTLESSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKLLIADDRTVIIGSANINDRSLLGKRDSELAILIEDTEMEPSLMDGVEYQAGRFALSLRKHCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIRGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

Gene Information

Entrez Gene ID
25097
Gene Name
phospholipase D2
Gene Symbol
Pld2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:RGD C Golgi apparatus
GO:0005901 IDA:RGD C caveola
GO:0030027 IDA:RGD C lamellipodium
GO:0005634 IDA:RGD C nucleus
GO:0005886 IDA:RGD C plasma membrane
GO:0042383 IDA:RGD C sarcolemma
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0004630 IDA:RGD F phospholipase D activity
GO:0005080 IPI:RGD F protein kinase C binding
GO:0031175 IMP:RGD P neuron projection development
GO:0009395 IMP:RGD P phospholipid catabolic process
GO:0045785 IMP:RGD P positive regulation of cell adhesion
GO:0030335 IMP:RGD P positive regulation of cell migration
GO:0043306 IMP:RGD P positive regulation of mast cell degranulation
GO:0014068 IMP:RGD P positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260 IMP:RGD P positive regulation of receptor-mediated endocytosis
GO:0042542 IMP:RGD P response to hydrogen peroxide
GO:0001666 IDA:RGD P response to hypoxia
GO:0014070 IDA:RGD P response to organic cyclic compound
GO:0043434 IMP:RGD P response to peptide hormone

KEGG Pathway Links

KEGG Pathway ID Description
ko04144 Endocytosis
rno04144 Endocytosis
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04724 Glutamatergic synapse
rno04724 Glutamatergic synapse
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko04912 GnRH signaling pathway
rno04912 GnRH signaling pathway
rno01100 Metabolic pathways
rno04014 Ras signaling pathway
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR015679 Phospholipase D family
IPR016555 Phospholipase D, eukaryota
IPR025202 Phospholipase D-like domain
IPR001736 Phospholipase D/Transphosphatidylase
IPR001683 Phox homologous domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase D2
Protein Entry
PLD2_RAT
UniProt ID
P70498
Species
Rat

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme Regulation Stimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylethanolamine. Inhibited by phosphatidylserine and by oleate. Is not responsive to ADP- ribosylation factor 1 (ARF1), nor to GTP-binding protein RhoA.
Function May have a role in signal-induced cytoskeletal regulation and/or endocytosis
Interaction P33535:Oprm1; NbExp=3; IntAct=EBI-6140589, EBI-4392569;
Ptm Phosphorylated on Tyr-11; most likely by EGFR (By similarity). Phosphorylated by FGR. {ECO:0000250, ECO:0000269|PubMed:15282299}.
Similarity Belongs to the phospholipase D family
Similarity Contains 1 PH domain
Similarity Contains 1 PX (phox homology) domain
Similarity Contains 2 PLD phosphodiesterase domains
Subcellular Location Membrane ; Peripheral membrane protein .
Subunit Interacts with PIP5K1B and EGFR
Tissue Specificity Expressed in brain, lung, heart, kidney, stomach, small intestine, colon, and testis, and at a much lower levels in thymus, liver and muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP012470 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31377516 RefSeq NP_150641 933 phospholipase D2

Identical Sequences to LMP012470 proteins

Reference Database Accession Length Protein Name
GI:31377516 DBBJ BAA19882.1 933 phospholipase D [Rattus norvegicus]
GI:31377516 GenBank EDM05018.1 933 phospholipase D2, isoform CRA_a [Rattus norvegicus]
GI:31377516 GenBank EDM05019.1 933 phospholipase D2, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012470 proteins

Reference Database Accession Length Protein Name
GI:31377516 DBBJ BAA19882.1 933 phospholipase D [Rattus norvegicus]
GI:31377516 GenBank EDM05018.1 933 phospholipase D2, isoform CRA_a [Rattus norvegicus]
GI:31377516 GenBank EDM05019.1 933 phospholipase D2, isoform CRA_a [Rattus norvegicus]