Gene/Proteome Database (LMPD)

LMPD ID
LMP012475
Gene ID
25146
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 17, subfamily a, polypeptide 1
Gene Symbol
Cyp17a1
Synonyms
Cyp17;
Alternate Names
steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; P450c17; P450-C17; P45017alpha; cytochrome P450c17; cytochrome P450-C17; cytochrome P450 17A1; cytochrome P450, subfamily 17; Cytochrome P450, subfamily XVII; 17-alpha-hydroxyprogesterone aldolase;
Chromosome
1
Map Location
1q55
EC Number
1.14.99.9
Summary
steroid hydroxylase that comprises a main component of the steroidogenic pathway; activity culminates in corticosteriod and androgen production in adrenal gland and sex steroid production in gonads [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp17a1

Proteins

steroid 17-alpha-hydroxylase/17,20 lyase precursor
Refseq ID NP_036885
Protein GI 6978731
UniProt ID P11715
mRNA ID NM_012753
Length 507
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2442 peptide sequence: MWELVGLLLLILAYFFWVKS

Gene Information

Entrez Gene ID
25146
Gene Name
cytochrome P450, family 17, subfamily a, polypeptide 1
Gene Symbol
Cyp17a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IEA:Ensembl C axon
GO:0042995 IDA:RGD C cell projection
GO:0005783 IDA:RGD C endoplasmic reticulum
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0043025 IDA:RGD C neuronal cell body
GO:0047442 IEA:UniProtKB-EC F 17-alpha-hydroxyprogesterone aldolase activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004508 IDA:RGD F steroid 17-alpha-monooxygenase activity
GO:0033327 IEP:RGD P Leydig cell differentiation
GO:0030325 IEP:RGD P adrenal gland development
GO:0006702 TAS:RGD P androgen biosynthetic process
GO:0018879 IEP:RGD P biphenyl metabolic process
GO:0071236 IEP:RGD P cellular response to antibiotic
GO:0071371 IEP:RGD P cellular response to gonadotropin stimulus
GO:0071222 IEP:RGD P cellular response to lipopolysaccharide
GO:0018894 IEP:RGD P dibenzo-p-dioxin metabolic process
GO:0006704 IEA:Ensembl P glucocorticoid biosynthetic process
GO:0021766 IEP:RGD P hippocampus development
GO:0042446 ISS:UniProtKB P hormone biosynthetic process
GO:0008584 IEP:RGD P male gonad development
GO:0006082 IEP:RGD P organic acid metabolic process
GO:0030728 IEP:RGD P ovulation
GO:0018958 IEP:RGD P phenol-containing compound metabolic process
GO:0018963 IEP:RGD P phthalate metabolic process
GO:0090031 IMP:RGD P positive regulation of steroid hormone biosynthetic process
GO:0042448 ISS:UniProtKB P progesterone metabolic process
GO:0010034 IEP:RGD P response to acetate
GO:0051591 IEP:RGD P response to cAMP
GO:0034097 IEP:RGD P response to cytokine
GO:0042493 IEP:RGD P response to drug
GO:0060992 IEP:RGD P response to fungicide
GO:0034698 IEP:RGD P response to gonadotropin
GO:0009635 IEP:RGD P response to herbicide
GO:0017085 IEP:RGD P response to insecticide
GO:0010212 IEP:RGD P response to ionizing radiation
GO:0051597 IEP:RGD P response to methylmercury
GO:0031667 IEP:RGD P response to nutrient levels
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0010033 IEP:RGD P response to organic substance
GO:0032526 IEP:RGD P response to retinoic acid
GO:0048545 IEP:RGD P response to steroid hormone
GO:0009636 IEP:RGD P response to toxic substance
GO:0006694 IMP:RGD P steroid biosynthetic process
GO:0008202 ISS:UniProtKB P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00109 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953941 Androgen biosynthesis
5953258 Biological oxidations
5953485 Cytochrome P450 - arranged by substrate type
5953932 Endogenous sterols
5953942 Glucocorticoid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953937 Metabolism of steroid hormones and vitamin D
5953326 Phase 1 - Functionalization of compounds

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 17, subfamily a, polypeptide 1
Protein Entry
CP17A_RAT
UniProt ID
P11715
Species
Rat

Comments

Comment Type Description
Catalytic Activity 17-alpha-hydroxyprogesterone = androst-4-ene- 3,17-dione + acetaldehyde.
Catalytic Activity A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O(2) = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Enzyme Regulation Regulated predominantly by intracellular cAMP levels.
Function Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the cytochrome P450 family
Subcellular Location Membrane .

Identical and Related Proteins

Unique RefSeq proteins for LMP012475 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978731 RefSeq NP_036885 507 steroid 17-alpha-hydroxylase/17,20 lyase precursor

Identical Sequences to LMP012475 proteins

Reference Database Accession Length Protein Name
GI:6978731 EMBL CAA49470.1 507 17-alpha hydroxylase [Rattus norvegicus]
GI:6978731 GenBank AAA41777.1 507 17-alpha hydroxylase [Rattus norvegicus]
GI:6978731 GenBank AAA41783.1 507 P-450 17-alpha protein [Rattus norvegicus]
GI:6978731 SwissProt P11715.2 507 RecName: Full=Steroid 17-alpha-hydroxylase/17,20 lyase; AltName: Full=17-alpha-hydroxyprogesterone aldolase; AltName: Full=CYPXVII; AltName: Full=Cytochrome P450 17A1; AltName: Full=Cytochrome P450-C17; Short=Cytochrome P450c17 [Rattus norvegicus]

Related Sequences to LMP012475 proteins

Reference Database Accession Length Protein Name
GI:6978731 GenBank AAA41777.1 507 17-alpha hydroxylase [Rattus norvegicus]
GI:6978731 GenBank AAA41783.1 507 P-450 17-alpha protein [Rattus norvegicus]
GI:6978731 SwissProt P11715.2 507 RecName: Full=Steroid 17-alpha-hydroxylase/17,20 lyase; AltName: Full=17-alpha-hydroxyprogesterone aldolase; AltName: Full=CYPXVII; AltName: Full=Cytochrome P450 17A1; AltName: Full=Cytochrome P450-C17; Short=Cytochrome P450c17 [Rattus norvegicus]