Gene/Proteome Database (LMPD)

LMPD ID
LMP012478
Gene ID
25154
Species
Rattus norvegicus (Rat)
Gene Name
progesterone receptor
Gene Symbol
Pgr
Alternate Names
progesterone receptor; PR; nuclear receptor subfamily 3 group C member 3;
Chromosome
8
Map Location
8q11
Summary
receptor for progesterone; regulates glutamic acid decarboxylase expression in the hypothalamus during proestrus; may mediate production of the GnRH and LH surge [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pgr

Proteins

progesterone receptor
Refseq ID NP_074038
Protein GI 12408292
UniProt ID Q63449
mRNA ID NM_022847
Length 923
MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLLFSRSCQAQELPDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSWCLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGAGQKVLPKAVSPPRQLLLPTSGSAHWPGAGVKPSQQPATVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRVSLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSPPVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPPRPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLPAAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDGVALPQSVAFPNESQTLGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK

Gene Information

Entrez Gene ID
25154
Gene Name
progesterone receptor
Gene Symbol
Pgr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IDA:RGD C axon
GO:0043679 IDA:RGD C axon terminus
GO:0005737 IDA:RGD C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0030425 IDA:RGD C dendrite
GO:0043197 IDA:RGD C dendritic spine
GO:0005783 IDA:RGD C endoplasmic reticulum
GO:0005739 IDA:RGD C mitochondrion
GO:0043005 IDA:RGD C neuron projection
GO:0005634 IDA:RGD C nucleus
GO:0043204 IDA:RGD C perikaryon
GO:0005886 IDA:RGD C plasma membrane
GO:0042562 IMP:RGD F hormone binding
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0003700 IEA:InterPro F sequence-specific DNA binding transcription factor activity
GO:0005496 IMP:RGD F steroid binding
GO:0003707 IMP:RGD F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0071372 IEP:RGD P cellular response to follicle-stimulating hormone stimulus
GO:0071371 IEP:RGD P cellular response to gonadotropin stimulus
GO:0071373 IEP:RGD P cellular response to luteinizing hormone stimulus
GO:0016101 IEP:RGD P diterpenoid metabolic process
GO:0060206 IEP:RGD P estrous cycle phase
GO:0060180 IMP:RGD P female mating behavior
GO:0001553 IEP:RGD P luteinization
GO:0043066 IMP:RGD P negative regulation of apoptotic process
GO:0045892 IEP:RGD P negative regulation of transcription, DNA-templated
GO:0008284 IDA:RGD P positive regulation of cell proliferation
GO:0014911 IMP:RGD P positive regulation of smooth muscle cell migration
GO:0045893 IDA:RGD P positive regulation of transcription, DNA-templated
GO:0042220 IDA:RGD P response to cocaine
GO:0043627 IEP:RGD P response to estrogen
GO:0032570 IEP:RGD P response to progesterone
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
ko04114 Oocyte meiosis
rno04114 Oocyte meiosis
ko04914 Progesterone-mediated oocyte maturation
rno04914 Progesterone-mediated oocyte maturation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway
5954400 Nuclear signaling by ERBB4
5953381 Signal Transduction
5953540 Signaling by ERBB4

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR000128 Progesterone receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
progesterone receptor
Protein Entry
PRGR_RAT
UniProt ID
Q63449
Species
Rat

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform is involved in activation of c-SRC/MAPK signaling on hormone stimulation (By similarity)
Ptm Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity)
Ptm Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-293 is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-387. Phosphorylation on Ser-344 also requires induction by hormone. Basal phosphorylation on Ser-82, Ser-190 and Ser-399 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-399 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-293, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-344 by ERK1/2 MAPK is required for interaction with SP1 (By similarity)
Ptm Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-387, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-293 (By similarity)
Ptm Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-293 (By similarity)
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity)
Subunit Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-344. Interacts with PRMT2 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012478 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12408292 RefSeq NP_074038 923 progesterone receptor

Identical Sequences to LMP012478 proteins

Reference Database Accession Length Protein Name
GI:12408292 GenBank AAA19916.1 923 progesterone receptor [Rattus norvegicus]
GI:12408292 SwissProt Q63449.1 923 RecName: Full=Progesterone receptor; Short=PR; AltName: Full=Nuclear receptor subfamily 3 group C member 3 [Rattus norvegicus]

Related Sequences to LMP012478 proteins

Reference Database Accession Length Protein Name
GI:12408292 GenBank AAA19916.1 923 progesterone receptor [Rattus norvegicus]
GI:12408292 GenBank EDL78508.1 926 rCG31710 [Rattus norvegicus]
GI:12408292 SwissProt Q63449.1 923 RecName: Full=Progesterone receptor; Short=PR; AltName: Full=Nuclear receptor subfamily 3 group C member 3 [Rattus norvegicus]