Gene/Proteome Database (LMPD)

LMPD ID
LMP012480
Gene ID
25239
Species
Rattus norvegicus (Rat)
Gene Name
apolipoprotein D
Gene Symbol
Apod
Synonyms
AOPDGN;
Alternate Names
apolipoprotein D; apo-D;
Chromosome
11
Map Location
11q11
Summary
may play a role in nerve repair in response to injury [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Apod

Proteins

apolipoprotein D precursor
Refseq ID NP_036909
Protein GI 6978523
UniProt ID P23593
mRNA ID NM_012777
Length 189
MATMLLLLATLAGLFTTTEGQSFHLGKCPSPPVQENFDVKKYLGRWYEIEKIPVSFEKGNCIQANYSLMENGNIKVLNKELRPDGTLNQVEGEAKQSNMSEPAKLEVQFFSLMPPAPYWILATDYESYALVYSCTTFFWFFHVDYVWILGRNPYLPPETITYLKYILTSNDIDIAKITTKDQANCPDFL
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2069 peptide sequence: MATMLLLLATLAGLFTTTEG mat_peptide: 20..189 product: apolipoprotein D calculated_mol_wt: 19642 peptide sequence: GQSFHLGKCPSPPVQENFDVKKYLGRWYEIEKIPVSFEKGNCIQANYSLMENGNIKVLNKELRPDGTLNQVEGEAKQSNMSEPAKLEVQFFSLMPPAPYWILATDYESYALVYSCTTFFWFFHVDYVWILGRNPYLPPETITYLKYILTSNDIDIAKITTKDQANCPDFL

Gene Information

Entrez Gene ID
25239
Gene Name
apolipoprotein D
Gene Symbol
Apod
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0022626 IDA:RGD C cytosolic ribosome
GO:0030425 IDA:RGD C dendrite
GO:0005783 IDA:RGD C endoplasmic reticulum
GO:0005615 ISS:UniProtKB C extracellular space
GO:0043025 IDA:RGD C neuronal cell body
GO:0048471 ISS:UniProtKB C perinuclear region of cytoplasm
GO:0015485 ISS:UniProtKB F cholesterol binding
GO:0005215 IEA:InterPro F transporter activity
GO:0007568 IEP:RGD P aging
GO:0007420 IEP:RGD P brain development
GO:0006006 ISS:UniProtKB P glucose metabolic process
GO:0006629 ISS:UniProtKB P lipid metabolic process
GO:2000405 ISS:UniProtKB P negative regulation of T cell migration
GO:1900016 ISS:UniProtKB P negative regulation of cytokine production involved in inflammatory response
GO:0051895 ISS:UniProtKB P negative regulation of focal adhesion assembly
GO:0060588 ISS:UniProtKB P negative regulation of lipoprotein lipid oxidation
GO:0071638 ISS:UniProtKB P negative regulation of monocyte chemotactic protein-1 production
GO:0010642 ISS:UniProtKB P negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0042308 ISS:UniProtKB P negative regulation of protein import into nucleus
GO:0048662 ISS:UniProtKB P negative regulation of smooth muscle cell proliferation
GO:2000098 ISS:UniProtKB P negative regulation of smooth muscle cell-matrix adhesion
GO:0014012 IEP:RGD P peripheral nervous system axon regeneration
GO:0048678 IEP:UniProtKB P response to axon injury
GO:0042493 IEP:RGD P response to drug
GO:0000302 ISS:UniProtKB P response to reactive oxygen species
GO:0042246 IEP:RGD P tissue regeneration

Domain Information

InterPro Annotations

Accession Description
IPR002969 Apolipoprotein D
IPR026222 Apolipoprotein D, vertebrates
IPR012674 Calycin
IPR011038 Calycin-like
IPR002345 Lipocalin
IPR022272 Lipocalin family conserved site
IPR022271 Lipocalin, ApoD type
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
apolipoprotein D
Protein Entry
APOD_RAT
UniProt ID
P23593
Species
Rat

Comments

Comment Type Description
Function APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Similarity Belongs to the calycin superfamily. Lipocalin family
Subcellular Location Secreted.
Subunit Homodimer.
Tissue Specificity Expressed in liver, kidney, bladder, adrenal, cerebrum, duodenum, testis, lung, spleen, pancreas, heart and skin

Identical and Related Proteins

Unique RefSeq proteins for LMP012480 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978523 RefSeq NP_036909 189 apolipoprotein D precursor

Identical Sequences to LMP012480 proteins

Reference Database Accession Length Protein Name
GI:6978523 EMBL CAA39158.1 189 apolipoprotein D [Rattus norvegicus]
GI:6978523 SwissProt P23593.1 189 RecName: Full=Apolipoprotein D; Short=Apo-D; Short=ApoD; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012480 proteins

Reference Database Accession Length Protein Name
GI:6978523 EMBL CAA39158.1 189 apolipoprotein D [Rattus norvegicus]
GI:6978523 GenBank EDM11472.1 204 apolipoprotein D, isoform CRA_a [Rattus norvegicus]
GI:6978523 SwissProt P23593.1 189 RecName: Full=Apolipoprotein D; Short=Apo-D; Short=ApoD; Flags: Precursor [Rattus norvegicus]