Gene/Proteome Database (LMPD)

LMPD ID
LMP012487
Gene ID
25267
Species
Rattus norvegicus (Rat)
Gene Name
platelet derived growth factor receptor, alpha polypeptide
Gene Symbol
Pdgfra
Synonyms
APDGFR; PDGFACE;
Alternate Names
platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGF-R-alpha; CD140 antigen-like family member A; alpha platelet-derived growth factor receptor; platelet-derived growth factor alpha receptor; alpha-type platelet-derived growth factor receptor;
Chromosome
14
Map Location
14p11
EC Number
2.7.10.1
Summary
acts as a receptor tyrosine kinase for PDGF; may play a role in glial cell generation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pdgfra

Proteins

platelet-derived growth factor receptor alpha precursor
Refseq ID NP_036934
Protein GI 158186636
UniProt ID P20786
mRNA ID NM_012802
Length 1088
MGTSQAFLVLSCLLTGPSLIVCQLLLPSILPNENEKIVPLSSSFSLRCFGESEVSWQHPMSEEEDPNVEIRTEENNSSLFVTVLEVVNASAAHTGWYTCYYNHTQTEESEIEGRHIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAIIPCRTTDPDTEVTLHNNGRLVPASYDSRQGFNGTFSVGPYICEATVRGRTFKTSEFNVYALKATSELNLEMDTRQTVYKAGETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLTVPKATVKDSGDYECAARQATKEVKEMKTVTISVHEKGFVQIRPTFGHLETVNLHQVREFVVEVQAYPTPRISWLKDNLTLIENLTEITTDVQRSQETRYQSKLKLIRAKEEDSGHYTIIVQNDDDMKSYTFELSTLVPASILELVDDHHGSGGGQTVRCTAEGTPLPNIEWMICKDIKKCNNDTSWTVLASNVSNIITEFHQRGRSTVEGRVSFAKVEETIAVRCLAKNDLGIGNRELKLVAPTLRSELTVAAAVLVLLVIVIVSLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYVDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKEWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
sig_peptide: 1..23 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P20786.2) calculated_mol_wt: 2382 peptide sequence: MGTSQAFLVLSCLLTGPSLIVCQ mat_peptide: 24..1088 product: Platelet-derived growth factor receptor alpha experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P20786.2) calculated_mol_wt: 120336 peptide sequence: LLLPSILPNENEKIVPLSSSFSLRCFGESEVSWQHPMSEEEDPNVEIRTEENNSSLFVTVLEVVNASAAHTGWYTCYYNHTQTEESEIEGRHIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAIIPCRTTDPDTEVTLHNNGRLVPASYDSRQGFNGTFSVGPYICEATVRGRTFKTSEFNVYALKATSELNLEMDTRQTVYKAGETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLTVPKATVKDSGDYECAARQATKEVKEMKTVTISVHEKGFVQIRPTFGHLETVNLHQVREFVVEVQAYPTPRISWLKDNLTLIENLTEITTDVQRSQETRYQSKLKLIRAKEEDSGHYTIIVQNDDDMKSYTFELSTLVPASILELVDDHHGSGGGQTVRCTAEGTPLPNIEWMICKDIKKCNNDTSWTVLASNVSNIITEFHQRGRSTVEGRVSFAKVEETIAVRCLAKNDLGIGNRELKLVAPTLRSELTVAAAVLVLLVIVIVSLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYVDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKEWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL

Gene Information

Entrez Gene ID
25267
Gene Name
platelet derived growth factor receptor, alpha polypeptide
Gene Symbol
Pdgfra
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005887 ISS:UniProtKB C integral component of plasma membrane
GO:0005634 IDA:UniProtKB C nucleus
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0043548 IPI:RGD F phosphatidylinositol 3-kinase binding
GO:0005018 IDA:RGD F platelet-derived growth factor alpha-receptor activity
GO:0046983 NAS:RGD F protein dimerization activity
GO:0042803 ISS:UniProtKB F protein homodimerization activity
GO:0005021 ISS:UniProtKB F vascular endothelial growth factor-activated receptor activity
GO:0055003 ISS:UniProtKB P cardiac myofibril assembly
GO:0060326 ISS:UniProtKB P cell chemotaxis
GO:0048701 ISS:UniProtKB P embryonic cranial skeleton morphogenesis
GO:0048557 ISS:UniProtKB P embryonic digestive tract morphogenesis
GO:0048704 ISS:UniProtKB P embryonic skeletal system morphogenesis
GO:0042063 IEP:RGD P gliogenesis
GO:0048839 IEP:RGD P inner ear development
GO:0001553 ISS:UniProtKB P luteinization
GO:0072277 ISS:UniProtKB P metanephric glomerular capillary formation
GO:0010544 ISS:UniProtKB P negative regulation of platelet activation
GO:0018108 ISS:UniProtKB P peptidyl-tyrosine phosphorylation
GO:0048015 ISS:UniProtKB P phosphatidylinositol-mediated signaling
GO:0070527 ISS:UniProtKB P platelet aggregation
GO:0048008 ISS:UniProtKB P platelet-derived growth factor receptor signaling pathway
GO:0035790 IDA:GOC P platelet-derived growth factor receptor-alpha signaling pathway
GO:0045740 ISS:UniProtKB P positive regulation of DNA replication
GO:0070374 ISS:UniProtKB P positive regulation of ERK1 and ERK2 cascade
GO:0030335 ISS:UniProtKB P positive regulation of cell migration
GO:0008284 IMP:RGD P positive regulation of cell proliferation
GO:0007204 ISS:UniProtKB P positive regulation of cytosolic calcium ion concentration
GO:0048146 ISS:UniProtKB P positive regulation of fibroblast proliferation
GO:0043552 ISS:UniProtKB P positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777 ISS:UniProtKB P protein autophosphorylation
GO:2000739 ISS:UniProtKB P regulation of mesenchymal stem cell differentiation
GO:0034097 IEP:RGD P response to cytokine
GO:0032355 IEP:RGD P response to estradiol
GO:0043627 IEP:RGD P response to estrogen
GO:0009725 IEP:RGD P response to hormone
GO:0055093 IEP:RGD P response to hyperoxia
GO:0010035 IEP:RGD P response to inorganic substance
GO:0010033 IEP:RGD P response to organic substance
GO:0061298 ISS:UniProtKB P retina vasculature development in camera-type eye
GO:0038084 ISS:GOC P vascular endothelial growth factor signaling pathway
GO:0042060 IEP:RGD P wound healing

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04060 Cytokine-cytokine receptor interaction
rno04060 Cytokine-cytokine receptor interaction
ko04144 Endocytosis
rno04144 Endocytosis
ko04510 Focal adhesion
rno04510 Focal adhesion
ko04540 Gap junction
rno04540 Gap junction
ko05214 Glioma
rno05214 Glioma
ko05166 HTLV-I infection
rno05166 HTLV-I infection
ko04010 MAPK signaling pathway
rno04010 MAPK signaling pathway
ko05218 Melanoma
rno05218 Melanoma
ko05206 MicroRNAs in cancer
rno05206 MicroRNAs in cancer
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
rno05200 Pathways in cancer
ko05215 Prostate cancer
rno05215 Prostate cancer
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton

REACTOME Pathway Links

REACTOME Pathway ID Description
5953415 Adaptive Immune System
5954570 Constitutive PI3K/AKT Signaling in Cancer
5953408 DAP12 interactions
5953407 DAP12 signaling
5953253 Disease
5953396 Downstream signal transduction
5953994 Downstream signaling events of B Cell Receptor (BCR)
5953399 Downstream signaling of activated FGFR
5953417 Fc epsilon receptor (FCERI) signaling
5953884 GAB1 signalosome
5953410 Immune System
5953409 Innate Immune System
5953394 NGF signalling via TRKA from the plasma membrane
5953885 PI-3K cascade
5953996 PI3K events in ERBB2 signaling
5953995 PI3K events in ERBB4 signaling
5953997 PI3K/AKT Signaling in Cancer
5953989 PI3K/AKT activation
5953993 PIP3 activates AKT signaling
5953998 Role of LAT2/NTAL/LAB on calcium mobilization
5953381 Signal Transduction
5953403 Signaling by EGFR
5953404 Signaling by EGFR in Cancer
5953406 Signaling by ERBB2
5953540 Signaling by ERBB4
5953400 Signaling by FGFR
5953401 Signaling by FGFR in disease
5953397 Signaling by PDGF
5953541 Signaling by SCF-KIT
5953414 Signaling by the B Cell Receptor (BCR)
5953395 Signalling by NGF

Domain Information

InterPro Annotations

Accession Description
IPR013098 Immunoglobulin I-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold
IPR027290 Platelet-derived growth factor receptor alpha
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR008266 Tyrosine-protein kinase, active site
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved site

UniProt Annotations

Entry Information

Gene Name
platelet derived growth factor receptor, alpha polypeptide
Protein Entry
PGFRA_RAT
UniProt ID
P20786
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE- ProRule:PRU10028}.
Enzyme Regulation Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib, nilotinib and sorafenib (By similarity)
Function Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity)
Ptm Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-730 and Tyr-741 is important for interaction with PIK3R1. Phosphorylation at Tyr-719 and Tyr-753 is important for interaction with PTPN11. Phosphorylation at Tyr-761 is important for interaction with CRK. Phosphorylation at Tyr-571 and Tyr-573 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-987 and Tyr-1017 is important for interaction with PLCG1 (By similarity)
Ptm Ubiquitinated, leading to its degradation
Sequence Caution Sequence=AAA40743.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
Similarity Contains 1 protein kinase domain
Similarity Contains 5 Ig-like C2-type (immunoglobulin-like) domains
Subcellular Location Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly internalized and degraded
Subunit Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine phosphorylated) with SHB (via SH2 domain). Interacts (tyrosine phosphorylated) with SHF (via SH2 domain). Interacts (tyrosine phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1. Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012487 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158186636 RefSeq NP_036934 1088 platelet-derived growth factor receptor alpha precursor

Identical Sequences to LMP012487 proteins

Reference Database Accession Length Protein Name
GI:158186636 GenBank EDL89926.1 1088 platelet derived growth factor receptor, alpha polypeptide, isoform CRA_a [Rattus norvegicus]
GI:158186636 RefSeq XP_006250941.1 1088 PREDICTED: platelet-derived growth factor receptor alpha isoform X1 [Rattus norvegicus]
GI:158186636 RefSeq XP_006250942.1 1088 PREDICTED: platelet-derived growth factor receptor alpha isoform X1 [Rattus norvegicus]
GI:158186636 RefSeq XP_006250943.1 1088 PREDICTED: platelet-derived growth factor receptor alpha isoform X1 [Rattus norvegicus]

Related Sequences to LMP012487 proteins

Reference Database Accession Length Protein Name
GI:158186636 RefSeq XP_006250941.1 1088 PREDICTED: platelet-derived growth factor receptor alpha isoform X1 [Rattus norvegicus]
GI:158186636 RefSeq XP_006250942.1 1088 PREDICTED: platelet-derived growth factor receptor alpha isoform X1 [Rattus norvegicus]
GI:158186636 RefSeq XP_006250943.1 1088 PREDICTED: platelet-derived growth factor receptor alpha isoform X1 [Rattus norvegicus]