Gene/Proteome Database (LMPD)

LMPD ID
LMP012489
Gene ID
25277
Species
Rattus norvegicus (Rat)
Gene Name
milk fat globule-EGF factor 8 protein
Gene Symbol
Mfge8
Synonyms
AGS; MFGME8; OAcGD3S; MFGMP-E8;
Alternate Names
lactadherin; MFGM; SED1; MFG-E8; O-acetyl GD3 ganglioside synthase; O-acetyl disialoganglioside synthase; O-acetyltransferase milk fat globule membrane protein; O-acetyltransferase Milk fat glolbule membrane protein;
Chromosome
1
Map Location
1q31
Summary
involved in the O-acetylation of GD3 ganglioside sialic acid [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Mfge8

Proteins

lactadherin isoform 1 precursor
Refseq ID NP_001035276
Protein GI 93277126
UniProt ID Q1PBJ1
mRNA ID NM_001040186
Length 483
MQFSRVLAALCGVLLCASGLFAASGDFCDSSLCLNGGTCLMGQDNDIYCLCPEGFTGLVCNETEKGPCSPNPCFHDAKCLVTEDTQRGDIFTEYICQCPVGYSGIHCELETTSYLDGEYLSSPAVPTTAVPTTAIPTTAVPTTAVPTTAVPTPAPNPDLSNHLASRCSTKLGLEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASSYDSKPWIQVDFLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRRFEFIQDESGTGDKEFMGNQDNNSLKINMFNPTLEAQYIRLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQITASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQKKVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGTSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPLSWHNRITLRLELLGC
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2271 peptide sequence: MQFSRVLAALCGVLLCASGLFA mat_peptide: 23..483 product: lactadherin isoform 1 calculated_mol_wt: 50848 peptide sequence: ASGDFCDSSLCLNGGTCLMGQDNDIYCLCPEGFTGLVCNETEKGPCSPNPCFHDAKCLVTEDTQRGDIFTEYICQCPVGYSGIHCELETTSYLDGEYLSSPAVPTTAVPTTAIPTTAVPTTAVPTTAVPTPAPNPDLSNHLASRCSTKLGLEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASSYDSKPWIQVDFLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRRFEFIQDESGTGDKEFMGNQDNNSLKINMFNPTLEAQYIRLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQITASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQKKVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGTSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPLSWHNRITLRLELLGC
lactadherin isoform 2 precursor
Refseq ID NP_036943
Protein GI 6981200
UniProt ID P70490
mRNA ID NM_012811
Length 427
MQFSRVLAALCGVLLCASGLFAASGDFCDSSLCLNGGTCLMGQDNDIYCLCPEGFTGLVCNETEKGPCSPNPCFHDAKCLVTEDTQRGDIFTEYICQCPVGYSGIHCELGCSTKLGLEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASSYDSKPWIQVDFLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRRFEFIQDESGTGDKEFMGNQDNNSLKINMFNPTLEAQYIRLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQITASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQKKVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGTSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPLSWHNRITLRLELLGC
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2271 peptide sequence: MQFSRVLAALCGVLLCASGLFA mat_peptide: 23..483 product: lactadherin isoform 1 calculated_mol_wt: 50848 peptide sequence: ASGDFCDSSLCLNGGTCLMGQDNDIYCLCPEGFTGLVCNETEKGPCSPNPCFHDAKCLVTEDTQRGDIFTEYICQCPVGYSGIHCELETTSYLDGEYLSSPAVPTTAVPTTAIPTTAVPTTAVPTTAVPTPAPNPDLSNHLASRCSTKLGLEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASSYDSKPWIQVDFLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRRFEFIQDESGTGDKEFMGNQDNNSLKINMFNPTLEAQYIRLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQITASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQKKVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGTSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPLSWHNRITLRLELLGC sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2271 peptide sequence: MQFSRVLAALCGVLLCASGLFA mat_peptide: 23..427 product: Lactadherin experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P70490.1) calculated_mol_wt: 45160 peptide sequence: ASGDFCDSSLCLNGGTCLMGQDNDIYCLCPEGFTGLVCNETEKGPCSPNPCFHDAKCLVTEDTQRGDIFTEYICQCPVGYSGIHCELGCSTKLGLEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASSYDSKPWIQVDFLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRRFEFIQDESGTGDKEFMGNQDNNSLKINMFNPTLEAQYIRLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQITASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQKKVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGTSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPLSWHNRITLRLELLGC

Gene Information

Entrez Gene ID
25277
Gene Name
milk fat globule-EGF factor 8 protein
Gene Symbol
Mfge8
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009897 IEA:Ensembl C external side of plasma membrane
GO:0031012 IEA:Ensembl C extracellular matrix
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0019897 IEA:Ensembl C extrinsic component of plasma membrane
GO:0008429 IEA:Ensembl F phosphatidylethanolamine binding
GO:0001786 IEA:Ensembl F phosphatidylserine binding
GO:0007155 IEA:InterPro P cell adhesion
GO:0006911 IEA:Ensembl P phagocytosis, engulfment
GO:0006910 IEA:Ensembl P phagocytosis, recognition
GO:2000427 IEA:Ensembl P positive regulation of apoptotic cell clearance

REACTOME Pathway Links

REACTOME Pathway ID Description
5954397 Amyloids
5953253 Disease

Domain Information

InterPro Annotations

Accession Description
IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR013032 EGF-like, conserved site
IPR000742 Epidermal growth factor-like domain
IPR008979 Galactose-binding domain-like
IPR027060 Lactadherin

UniProt Annotations

Entry Information

Gene Name
milk fat globule-EGF factor 8 protein
Protein Entry
Q1PBJ1_RAT
UniProt ID
Q1PBJ1
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012489 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
93277126 RefSeq NP_001035276 483 lactadherin isoform 1 precursor
6981200 RefSeq NP_036943 427 lactadherin isoform 2 precursor

Identical Sequences to LMP012489 proteins

Reference Database Accession Length Protein Name
GI:6981200 DBBJ BAA12210.1 427 O-acetyl GD3 ganglioside synthase [Rattus norvegicus]
GI:6981200 GenBank AAH85754.1 427 Milk fat globule-EGF factor 8 protein [Rattus norvegicus]
GI:93277126 GenBank ABE67093.1 483 MFGE8 long form [Rattus norvegicus]
GI:6981200 GenBank EDM08572.1 427 milk fat globule-EGF factor 8 protein, isoform CRA_a [Rattus norvegicus]
GI:6981200 SwissProt P70490.1 427 RecName: Full=Lactadherin; AltName: Full=MFGM; AltName: Full=Milk fat globule-EGF factor 8; Short=MFG-E8; AltName: Full=O-acetyl GD3 ganglioside synthase; Short=AGS; AltName: Full=SED1; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012489 proteins

Reference Database Accession Length Protein Name
GI:6981200 DBBJ BAA12210.1 427 O-acetyl GD3 ganglioside synthase [Rattus norvegicus]
GI:6981200 GenBank AAH85754.1 427 Milk fat globule-EGF factor 8 protein [Rattus norvegicus]
GI:93277126 GenBank ABE67093.1 483 MFGE8 long form [Rattus norvegicus]
GI:93277126 GenBank EDL07077.1 463 milk fat globule-EGF factor 8 protein, isoform CRA_c [Mus musculus]
GI:6981200 GenBank EDM08572.1 427 milk fat globule-EGF factor 8 protein, isoform CRA_a [Rattus norvegicus]
GI:93277126 GenBank AGO74275.1 463 Sequence 1 from patent US 8398984