Gene/Proteome Database (LMPD)

LMPD ID
LMP012493
Gene ID
25287
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA dehydrogenase, long chain
Gene Symbol
Acadl
Synonyms
LCAD; ACOADA;
Alternate Names
long-chain specific acyl-CoA dehydrogenase, mitochondrial; long-chain acyl-CoA dehydrogenase; LCAD long chain acyl-CoA dehydrogenase; Acyl Coenzyme A dehydrogenase, long chain; acyl-Coenzyme A dehydrogenase, long-chain; acetyl-Coenzyme A dehydrogenase, long-chain;
Chromosome
9
Map Location
9q32
EC Number
1.3.8.8
Summary
catalyzes the alpha, beta-dehydrogenation of acyl-CoA esters in fatty acid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acadl

Proteins

long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID NP_036951
Protein GI 6978431
UniProt ID P15650
mRNA ID NM_012819
Length 430
MAARLLLRSLRVLSARSATLPPPSARCSHSGAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPYHEEWEKAGEVSRELWEKAGKQGLLGINIAEKHGGIGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEQFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHGISLFLVENGMKGFIKGKKLHKMGMKAQDTAELFFEDVRLPASALLGEENKGFYYLMQELPQERLLIADLAISACEFMFEETRNYVRQRKAFGKTVAHIQTVQHKLAELKTNICVTRAFVDSCLQLHETKRLDSASASMAKYWASELQNTVAYQCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIARQIVSDS
transit_peptide: 1..30 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P15650.1) calculated_mol_wt: 3219 peptide sequence: MAARLLLRSLRVLSARSATLPPPSARCSHS mat_peptide: 31..430 product: long-chain specific acyl-CoA dehydrogenase, mitochondrial EC_number: 1.3.8.1 note: putative calculated_mol_wt: 44672 peptide sequence: GAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPYHEEWEKAGEVSRELWEKAGKQGLLGINIAEKHGGIGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEQFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHGISLFLVENGMKGFIKGKKLHKMGMKAQDTAELFFEDVRLPASALLGEENKGFYYLMQELPQERLLIADLAISACEFMFEETRNYVRQRKAFGKTVAHIQTVQHKLAELKTNICVTRAFVDSCLQLHETKRLDSASASMAKYWASELQNTVAYQCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIARQIVSDS

Gene Information

Entrez Gene ID
25287
Gene Name
acyl-CoA dehydrogenase, long chain
Gene Symbol
Acadl
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IDA:BHF-UCL C mitochondrial matrix
GO:0031966 IDA:BHF-UCL C mitochondrial membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0000062 IDA:RGD F fatty-acyl-CoA binding
GO:0050660 IDA:RGD F flavin adenine dinucleotide binding
GO:0004466 IDA:RGD F long-chain-acyl-CoA dehydrogenase activity
GO:0016401 IEA:Ensembl F palmitoyl-CoA oxidase activity
GO:0042413 IEA:Ensembl P carnitine catabolic process
GO:0019254 IEA:Ensembl P carnitine metabolic process, CoA-linked
GO:0033539 IDA:RGD P fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042758 IDA:RGD P long-chain fatty acid catabolic process
GO:0045717 IEA:Ensembl P negative regulation of fatty acid biosynthetic process
GO:0046322 IEA:Ensembl P negative regulation of fatty acid oxidation
GO:0051289 IDA:RGD P protein homotetramerization
GO:0090181 IEA:Ensembl P regulation of cholesterol metabolic process
GO:0001659 IEA:Ensembl P temperature homeostasis

KEGG Pathway Links

KEGG Pathway ID Description
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
M00087 beta-Oxidation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953496 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
5953498 Beta oxidation of myristoyl-CoA to lauroyl-CoA
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953287 Mitochondrial Fatty Acid Beta-Oxidation
5953497 mitochondrial fatty acid beta-oxidation of saturated fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-CoA dehydrogenase, long chain
Protein Entry
ACADL_RAT
UniProt ID
P15650
Species
Rat

Comments

Comment Type Description
Catalytic Activity Long-chain-acyl-CoA + electron-transfer flavoprotein = long-chain-2,3-dehydroacyl-CoA + reduced electron- transfer flavoprotein.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Miscellaneous A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
Pathway Lipid metabolism; mitochondrial fatty acid beta- oxidation.
Ptm Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3 (By similarity)
Similarity Belongs to the acyl-CoA dehydrogenase family
Subcellular Location Mitochondrion matrix.
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012493 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978431 RefSeq NP_036951 430 long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Identical Sequences to LMP012493 proteins

Reference Database Accession Length Protein Name
GI:6978431 GenBank AAH62006.1 430 Acyl-Coenzyme A dehydrogenase, long-chain [Rattus norvegicus]
GI:6978431 GenBank EDL75290.1 430 acetyl-Coenzyme A dehydrogenase, long-chain, isoform CRA_a [Rattus norvegicus]
GI:6978431 GenBank AHH58256.1 430 Sequence 1 from patent US 8617877
GI:6978431 PRF - 430 long chain acyl-CoA dehydrogenase [Rattus norvegicus]

Related Sequences to LMP012493 proteins

Reference Database Accession Length Protein Name
GI:6978431 GenBank AAA40668.1 430 long chain acyl-CoA dehydrogenase precursor (EC 1.3.99.2) [Rattus norvegicus]
GI:6978431 GenBank AHH58256.1 430 Sequence 1 from patent US 8617877
GI:6978431 SwissProt P15650.1 430 RecName: Full=Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Short=LCAD; Flags: Precursor [Rattus norvegicus]