Gene/Proteome Database (LMPD)

LMPD ID
LMP012499
Gene ID
25322
Species
Rattus norvegicus (Rat)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Gene Symbol
Hsd17b1
Synonyms
17BHD1;
Alternate Names
estradiol 17-beta-dehydrogenase 1; 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; Hydroxysteroid dehydrogenase 17 beta, type 1;
Chromosome
10
Map Location
10q32.1
EC Number
1.1.1.62
Summary
catalyzes the conversion between 17 beta-hydroxy- and 17-ketosteroids; plays a role in estradiol biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Hsd17b1

Proteins

estradiol 17-beta-dehydrogenase 1
Refseq ID NP_036983
Protein GI 6981048
UniProt ID P51657
mRNA ID NM_012851
Length 344
MDSTVVLITGCSSGIGLHLAVRLASDRSQSFKVYATLRDLKSQGPLLEAARAQGCPPGSLEILELDVRDSESVAAARACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFHEKLEGGPGGALERADAQTRHLFAHYQRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVEAMHREAFSDLQVQEGAKAGAQVSGDPDTPPRALICLPECAIPRVTAELGWSASDKPGQNKSCYQQKI

Gene Information

Entrez Gene ID
25322
Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Gene Symbol
Hsd17b1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0031965 IEA:Ensembl C nuclear membrane
GO:0004303 IDA:RGD F estradiol 17-beta-dehydrogenase activity
GO:0047035 IDA:RGD F testosterone dehydrogenase (NAD+) activity
GO:0060348 IEP:RGD P bone development
GO:0071248 IEP:RGD P cellular response to metal ion
GO:0006703 IDA:RGD P estrogen biosynthetic process
GO:0061370 IDA:RGD P testosterone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953940 Estrogen biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953937 Metabolism of steroid hormones and vitamin D

Domain Information

InterPro Annotations

Accession Description
IPR011348 17beta-dehydrogenase
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Protein Entry
DHB1_RAT
UniProt ID
P51657
Species
Rat

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Function Favors the reduction of estrogens and androgens. Uses preferentially NADH.
Pathway Steroid biosynthesis; estrogen biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular Location Cytoplasm.
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012499 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981048 RefSeq NP_036983 344 estradiol 17-beta-dehydrogenase 1

Identical Sequences to LMP012499 proteins

Reference Database Accession Length Protein Name
GI:6981048 EMBL CAA66657.1 344 17 beta hydroxysteroid dehydrogenase type I [Rattus norvegicus]
GI:6981048 GenBank AAH86365.1 344 Hydroxysteroid (17-beta) dehydrogenase 1 [Rattus norvegicus]
GI:6981048 GenBank EDM06082.1 344 hydroxysteroid (17-beta) dehydrogenase 1 [Rattus norvegicus]
GI:6981048 SwissProt P51657.1 344 RecName: Full=Estradiol 17-beta-dehydrogenase 1; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 1; Short=17-beta-HSD 1 [Rattus norvegicus]

Related Sequences to LMP012499 proteins

Reference Database Accession Length Protein Name
GI:6981048 EMBL CAA66349.1 344 17-beta-hydroxysteroid dehydrogenase type I [Rattus norvegicus]
GI:6981048 GenBank EDM06082.1 344 hydroxysteroid (17-beta) dehydrogenase 1 [Rattus norvegicus]
GI:6981048 SwissProt P51657.1 344 RecName: Full=Estradiol 17-beta-dehydrogenase 1; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 1; Short=17-beta-HSD 1 [Rattus norvegicus]