Gene/Proteome Database (LMPD)

LMPD ID
LMP012500
Gene ID
25330
Species
Rattus norvegicus (Rat)
Gene Name
lipase, hormone sensitive
Gene Symbol
Lipe
Synonyms
HSL;
Alternate Names
hormone-sensitive lipase; lipase E; hormone - sensitive lipase testicular isoform;
Chromosome
1
Map Location
1q21
EC Number
3.1.1.79;
Summary
enzyme involved in hydrolysis of stored triglycerides and fatty acids; important for regulation of energy homeostasis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lipe

Proteins

hormone-sensitive lipase
Refseq ID NP_036991
Protein GI 6981164
UniProt ID P15304
mRNA ID NM_012859
Length 1068
MKPRRPISFTREITAMEPSSTSVSRPEWRPEAQQTLTDYPGSRELQEFGIPQKQSLPNEATAQQGAEFQQEQGVQQSTLLQKLLTPLAFPVPQQSFPSHKVHSDQQEATSQNGPGAGKVHTTQKELEHRDEHVGTAESGPAEPPPATEVEATSIAQAVSGPDKKLPTQTDLVSQERAEQSDPTAQQTPLVQGVKSDQGSLIESGILARLQKLAIQQPSQEWKTFLDCVTESDMEKYLNSSSKSNPPEPSGGTVIPGTLPSKQKPDCGKMSGYGGKLPHGKKGILQKHKHYWDTASAFSHSMDLRTMTQSLVALAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRASHNLAELEAYLAALTQLRALAYYAQRLLTINRPGVLFFEGDEGLSADFLQDYVTLHKGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPVLARLISYDLREGQDSKMLNSLAKSEGPRLELRPRPQQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIISIDYSLAPEAPFPRALEECFFAYCWAVKHCELLGSTGERICLAGDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTETEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPHKTPLPATETLRPTDSGRLTESMRRSVSEAALAQPEGLLGTDSLKKLTIKDLSFKGNSEPSDSPEMSQSMETLGPSTPSDVNFFLRSGNSQEEAETRDDISPMDGIPRVRAAFPDGFHPRRSSQGVLHMPLYSSPIVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLGQPVTLKVVEDLPHGFLSLAALCRETRQAAELCVQRIRLILTPPAAPLT

Gene Information

Entrez Gene ID
25330
Gene Name
lipase, hormone sensitive
Gene Symbol
Lipe
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005901 ISS:UniProtKB C caveola
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005615 IDA:RGD C extracellular space
GO:0005811 ISS:UniProtKB C lipid particle
GO:0005739 ISS:UniProtKB C mitochondrion
GO:0005634 ISS:UniProtKB C nucleus
GO:0047372 IDA:RGD F acylglycerol lipase activity
GO:0033878 IEA:UniProtKB-EC F hormone-sensitive lipase activity
GO:0016788 IDA:RGD F hydrolase activity, acting on ester bonds
GO:0042134 ISS:UniProtKB F rRNA primary transcript binding
GO:0008203 IEA:UniProtKB-KW P cholesterol metabolic process
GO:0007565 IEP:RGD P female pregnancy
GO:0016042 ISS:UniProtKB P lipid catabolic process
GO:0042493 IEP:RGD P response to drug
GO:0006363 ISS:UniProtKB P termination of RNA polymerase I transcription
GO:0006361 ISS:UniProtKB P transcription initiation from RNA polymerase I promoter
GO:0019433 IDA:RGD P triglyceride catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013094 Alpha/beta hydrolase fold-3
IPR010468 Hormone-sensitive lipase, N-terminal
IPR002168 Lipase, GDXG, active site

UniProt Annotations

Entry Information

Gene Name
lipase, hormone sensitive
Protein Entry
LIPS_RAT
UniProt ID
P15304
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Testicular; IsoId=P15304-1; Sequence=Displayed; Name=2; IsoId=P15304-2; Sequence=VSP_017117;
Catalytic Activity Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate.
Catalytic Activity Monoacylglycerol + H(2)O = glycerol + a carboxylate.
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Enzyme Regulation Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.
Function In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Pathway Glycerolipid metabolism; triacylglycerol degradation.
Ptm Phosphorylation by AMPK may block translocation to lipid droplets
Similarity Belongs to the 'GDXG' lipolytic enzyme family
Subcellular Location Cell membrane . Membrane, caveola {ECO:0000250}. Cytoplasm, cytosol . Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation
Subunit Interacts with PTRF in the adipocyte cytoplasm (By similarity). Interacts with PLIN5. {ECO:0000250, ECO:0000269|PubMed:24303154}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012500 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981164 RefSeq NP_036991 1068 hormone-sensitive lipase

Identical Sequences to LMP012500 proteins

Reference Database Accession Length Protein Name
GI:6981164 GenBank AAC52771.1 1068 hormone-sensitive lipase testicular isoform [Rattus norvegicus]
GI:6981164 SwissProt P15304.3 1068 RecName: Full=Hormone-sensitive lipase; Short=HSL [Rattus norvegicus]

Related Sequences to LMP012500 proteins

Reference Database Accession Length Protein Name
GI:6981164 GenBank AAC52771.1 1068 hormone-sensitive lipase testicular isoform [Rattus norvegicus]
GI:6981164 GenBank EDM08026.1 1068 lipase, hormone sensitive, isoform CRA_a [Rattus norvegicus]
GI:6981164 SwissProt P15304.3 1068 RecName: Full=Hormone-sensitive lipase; Short=HSL [Rattus norvegicus]