Gene/Proteome Database (LMPD)

LMPD ID
LMP012503
Gene ID
25363
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA dehydrogenase, very long chain
Gene Symbol
Acadvl
Synonyms
VLCAD;
Alternate Names
very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Very long chain Acyl-Coa dehydrogenase; VLCAD very-long-chain acyl-CoA dehydrogenase; acyl-Coenzyme A dehydrogenase, very long chain;
Chromosome
10
Map Location
10q24
EC Number
1.3.8.9
Summary
catalyzes the beta-oxidation of long-chain fatty acids in mitochondrial fatty acid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acadvl

Proteins

very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID NP_037023
Protein GI 6978435
UniProt ID P45953
mRNA ID NM_012891
Length 655
MQSARMTPSVGRQLLRLGARSSRSAALQGQPRPTSAQRLYASEATQAVLEKPETLSSDASTREKPARAESKSFAVGMFKGQLTTDQVFPYPSVLNEGQTQFLKELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAVPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVLGEVGDGFKVAVNILNNGRFGMAATLAGTMKAIIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVALQGCMDKGKELTGLGNALKNPLGNVGLLIGEASKQLRRRTGIGSGLSLSGIVHPELSRSGELAVQALEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQSNPQQQELFRNFRSISKAMVENGGLVTSNPLRV
transit_peptide: 1..40 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P45953.1) calculated_mol_wt: 4385 peptide sequence: MQSARMTPSVGRQLLRLGARSSRSAALQGQPRPTSAQRLY mat_peptide: 41..655 product: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P45953.1) calculated_mol_wt: 66383 peptide sequence: ASEATQAVLEKPETLSSDASTREKPARAESKSFAVGMFKGQLTTDQVFPYPSVLNEGQTQFLKELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAVPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVLGEVGDGFKVAVNILNNGRFGMAATLAGTMKAIIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVALQGCMDKGKELTGLGNALKNPLGNVGLLIGEASKQLRRRTGIGSGLSLSGIVHPELSRSGELAVQALEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQSNPQQQELFRNFRSISKAMVENGGLVTSNPLRV

Gene Information

Entrez Gene ID
25363
Gene Name
acyl-CoA dehydrogenase, very long chain
Gene Symbol
Acadvl
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 IDA:RGD C mitochondrial inner membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0003995 IDA:RGD F acyl-CoA dehydrogenase activity
GO:0000062 IDA:RGD F fatty-acyl-CoA binding
GO:0050660 IDA:RGD F flavin adenine dinucleotide binding
GO:0004466 IDA:RGD F long-chain-acyl-CoA dehydrogenase activity
GO:0017099 IDA:RGD F very-long-chain-acyl-CoA dehydrogenase activity
GO:0006635 IDA:RGD P fatty acid beta-oxidation
GO:0033539 IMP:RGD P fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042760 IMP:RGD P very long-chain fatty acid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
M00087 beta-Oxidation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953499 Beta oxidation of palmitoyl-CoA to myristoyl-CoA
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5954165 IRE1alpha activates chaperones
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953345 Metabolism of proteins
5953287 Mitochondrial Fatty Acid Beta-Oxidation
5954163 Unfolded Protein Response (UPR)
5954505 XBP1(S) activates chaperone genes
5953497 mitochondrial fatty acid beta-oxidation of saturated fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-CoA dehydrogenase, very long chain
Protein Entry
ACADV_RAT
UniProt ID
P45953
Species
Rat

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Function Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.
Miscellaneous A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
Pathway Lipid metabolism; mitochondrial fatty acid beta- oxidation.
Ptm S-nitrosylation at Cys-237 in liver improves catalytic efficiency
Similarity Belongs to the acyl-CoA dehydrogenase family
Subcellular Location Mitochondrion inner membrane.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012503 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978435 RefSeq NP_037023 655 very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Identical Sequences to LMP012503 proteins

Reference Database Accession Length Protein Name
GI:6978435 DBBJ BAA06331.1 655 very-long-chain Acy1-CoA dehydrogenase [Rattus norvegicus]
GI:6978435 SwissProt P45953.1 655 RecName: Full=Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Short=VLCAD; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012503 proteins

Reference Database Accession Length Protein Name
GI:6978435 DBBJ BAA06331.1 655 very-long-chain Acy1-CoA dehydrogenase [Rattus norvegicus]
GI:6978435 GenBank EDM04964.1 655 acyl-Coenzyme A dehydrogenase, very long chain, isoform CRA_c [Rattus norvegicus]
GI:6978435 SwissProt P45953.1 655 RecName: Full=Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Short=VLCAD; Flags: Precursor [Rattus norvegicus]