Gene/Proteome Database (LMPD)

LMPD ID
LMP012504
Gene ID
25380
Species
Rattus norvegicus (Rat)
Gene Name
annexin A1
Gene Symbol
Anxa1
Synonyms
p35; Anx1;
Alternate Names
annexin A1; annexin I; annexin-1; calpactin-2; calpactin II; lipocortin 1; lipocortin I; chromobindin-9; Annexin 1 (p35) (Lipocortin 1); phospholipase A2 inhibitory protein;
Chromosome
1
Map Location
1q51
Summary
plays a role in regulation of insulin secretion; may inhibit phopsholipase A2 [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Anxa1

Proteins

annexin A1
Refseq ID NP_037036
Protein GI 6978501
UniProt ID P07150
mRNA ID NM_012904
Length 346
MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGDYEKILVALCGGN

Gene Information

Entrez Gene ID
25380
Gene Name
annexin A1
Gene Symbol
Anxa1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IEA:Ensembl C cell surface
GO:0005929 IEA:UniProtKB-KW C cilium
GO:0001533 IEA:Ensembl C cornified envelope
GO:0005737 IDA:RGD C cytoplasm
GO:0005615 IDA:RGD C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0042629 IDA:RGD C mast cell granule
GO:0031966 IDA:RGD C mitochondrial membrane
GO:0005634 IDA:RGD C nucleus
GO:0005886 IDA:RGD C plasma membrane
GO:0043234 IDA:RGD C protein complex
GO:0042383 IEA:Ensembl C sarcolemma
GO:0036310 IMP:RGD F annealing helicase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005544 TAS:RGD F calcium-dependent phospholipid binding
GO:0033676 IMP:RGD F double-stranded DNA-dependent ATPase activity
GO:0004386 IMP:RGD F helicase activity
GO:0019834 IDA:RGD F phospholipase A2 inhibitor activity
GO:0005543 IDA:RGD F phospholipid binding
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0003697 IDA:RGD F single-stranded DNA binding
GO:0005198 IEA:Ensembl F structural molecule activity
GO:0006200 IMP:GOC P ATP catabolic process
GO:0032508 IMP:RGD P DNA duplex unwinding
GO:0036292 IMP:RGD P DNA rewinding
GO:0000733 IMP:GOC P DNA strand renaturation
GO:0046632 IEA:Ensembl P alpha-beta T cell differentiation
GO:0050482 IEA:Ensembl P arachidonic acid secretion
GO:0007166 IDA:RGD P cell surface receptor signaling pathway
GO:0071385 IDA:BHF-UCL P cellular response to glucocorticoid stimulus
GO:0070301 IMP:RGD P cellular response to hydrogen peroxide
GO:0031018 IEP:RGD P endocrine pancreas development
GO:0060206 IEP:RGD P estrous cycle phase
GO:0042063 IEP:RGD P gliogenesis
GO:0070365 IEP:RGD P hepatocyte differentiation
GO:0030073 IDA:RGD P insulin secretion
GO:0030216 IEA:Ensembl P keratinocyte differentiation
GO:2000483 IEA:Ensembl P negative regulation of interleukin-8 secretion
GO:1900138 IDA:RGD P negative regulation of phospholipase A2 activity
GO:0050709 IMP:RGD P negative regulation of protein secretion
GO:0097350 IEA:Ensembl P neutrophil clearance
GO:0018149 IEA:Ensembl P peptide cross-linking
GO:1900087 IEA:Ensembl P positive regulation of G1/S transition of mitotic cell cycle
GO:0043065 IMP:RGD P positive regulation of apoptotic process
GO:0033031 IEA:Ensembl P positive regulation of neutrophil apoptotic process
GO:0031394 IMP:RGD P positive regulation of prostaglandin biosynthetic process
GO:0031340 IEA:Ensembl P positive regulation of vesicle fusion
GO:0070459 IMP:RGD P prolactin secretion
GO:0030850 IEP:RGD P prostate gland development
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0010165 IEP:RGD P response to X-ray
GO:0031960 IEP:RGD P response to corticosteroid
GO:0042493 IEP:RGD P response to drug
GO:0032355 IEP:RGD P response to estradiol
GO:0051384 IEP:RGD P response to glucocorticoid
GO:0009725 IEP:RGD P response to hormone
GO:0070555 IEP:RGD P response to interleukin-1
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0043434 IEP:RGD P response to peptide hormone

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954200 Formyl peptide receptors bind formyl peptides and many other ligands
5954152 G alpha (i) signalling events
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954121 Peptide ligand-binding receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018252 Annexin repeat, conserved site
IPR002388 Annexin, type I
IPR018502 Annexin_repeat

UniProt Annotations

Entry Information

Gene Name
annexin A1
Protein Entry
ANXA1_RAT
UniProt ID
P07150
Species
Rat

Comments

Comment Type Description
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Ptm Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity (By similarity)
Similarity Belongs to the annexin family
Similarity Contains 4 annexin repeats
Subcellular Location Nucleus . Cytoplasm {ECO:0000250}. Cell projection, cilium . Basolateral cell membrane . Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages
Subunit Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012504 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978501 RefSeq NP_037036 346 annexin A1

Identical Sequences to LMP012504 proteins

Reference Database Accession Length Protein Name
GI:6978501 GenBank AAH61710.1 346 Annexin A1 [Rattus norvegicus]
GI:6978501 GenBank EDM12990.1 346 annexin A1 [Rattus norvegicus]
GI:6978501 GenBank AEU43374.1 346 Sequence 123 from patent US 8052970
GI:6978501 RefSeq XP_008758517.1 346 PREDICTED: annexin A1 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012504 proteins

Reference Database Accession Length Protein Name
GI:6978501 GenBank AAH61710.1 346 Annexin A1 [Rattus norvegicus]
GI:6978501 GenBank EDM12990.1 346 annexin A1 [Rattus norvegicus]
GI:6978501 RefSeq XP_008758517.1 346 PREDICTED: annexin A1 isoform X1 [Rattus norvegicus]