Gene/Proteome Database (LMPD)

LMPD ID
LMP012505
Gene ID
25383
Species
Rattus norvegicus (Rat)
Gene Name
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Gene Symbol
Apobec1
Synonyms
REPR;
Alternate Names
C->U-editing enzyme APOBEC-1; Apolipoprotein B editing protein; apolipoprotein B editing complex 1; apolipoprotein B mRNA-editing enzyme 1;
Chromosome
4
Map Location
4q42
EC Number
3.5.4.-
Summary
required for post transcriptional editing of apolipoprotein B mRNA [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Apobec1

Proteins

C->U-editing enzyme APOBEC-1
Refseq ID NP_037039
Protein GI 6978519
UniProt ID P38483
mRNA ID NM_012907
Length 229
MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNTNKHVEVNFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIARLYHHADPRNRQGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLWVRLYVLELYCIILGLPPCLNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK

Gene Information

Entrez Gene ID
25383
Gene Name
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Gene Symbol
Apobec1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005634 NAS:UniProtKB C nucleus
GO:0017091 IEA:Ensembl F AU-rich element binding
GO:0003723 NAS:UniProtKB F RNA binding
GO:0004126 NAS:UniProtKB F cytidine deaminase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0080111 ISS:UniProtKB P DNA demethylation
GO:0032869 IEP:RGD P cellular response to insulin stimulus
GO:0009972 IDA:GOC P cytidine deamination
GO:0046087 IC:UniProtKB P cytidine metabolic process
GO:0016554 IDA:RGD P cytidine to uridine editing
GO:0051607 IDA:RGD P defense response to virus
GO:0042158 IEA:Ensembl P lipoprotein biosynthetic process
GO:0042953 IEA:Ensembl P lipoprotein transport
GO:0016556 IDA:RGD P mRNA modification
GO:0006397 IEA:UniProtKB-KW P mRNA processing
GO:0048255 IEA:Ensembl P mRNA stabilization
GO:0090310 ISS:UniProtKB P negative regulation of methylation-dependent chromatin silencing
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0051592 IDA:RGD P response to calcium ion
GO:0042493 IDA:RGD P response to drug
GO:0045471 IDA:RGD P response to ethanol
GO:0010332 IEA:Ensembl P response to gamma radiation
GO:0006970 IDA:RGD P response to osmotic stress
GO:0010043 IEP:RGD P response to zinc ion

REACTOME Pathway Links

REACTOME Pathway ID Description
5953511 Formation of the Editosome
5953330 Gene Expression
5953446 mRNA Editing
5953512 mRNA Editing: C to U Conversion

Domain Information

InterPro Annotations

Accession Description
IPR013158 APOBEC-like, N-terminal
IPR016192 APOBEC/CMP deaminase, zinc-binding
IPR016193 Cytidine_deaminase-like

UniProt Annotations

Entry Information

Gene Name
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Protein Entry
ABEC1_RAT
UniProt ID
P38483
Species
Rat

Comments

Comment Type Description
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ;
Function Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Similarity Belongs to the cytidine and deoxycytidylate deaminase family
Subcellular Location Cytoplasm .
Subunit Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Interacts with SYNCRIP. Interacts with HNRPAB (By similarity)
Tissue Specificity Expressed in the liver as well as small intestine.

Identical and Related Proteins

Unique RefSeq proteins for LMP012505 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978519 RefSeq NP_037039 229 C->U-editing enzyme APOBEC-1

Identical Sequences to LMP012505 proteins

Reference Database Accession Length Protein Name
GI:6978519 RefSeq XP_006237353.1 229 PREDICTED: C->U-editing enzyme APOBEC-1 isoform X1 [Rattus norvegicus]
GI:6978519 RefSeq XP_006237354.1 229 PREDICTED: C->U-editing enzyme APOBEC-1 isoform X1 [Rattus norvegicus]
GI:6978519 RefSeq XP_006237355.1 229 PREDICTED: C->U-editing enzyme APOBEC-1 isoform X1 [Rattus norvegicus]
GI:6978519 RefSeq XP_008761442.1 229 PREDICTED: C->U-editing enzyme APOBEC-1 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012505 proteins

Reference Database Accession Length Protein Name
GI:6978519 GenBank AAA71553.1 229 Sequence 2 from patent US 5434058
GI:6978519 GenBank AAB15313.1 229 Sequence 2 from patent US 5550034
GI:6978519 SwissProt P38483.1 229 RecName: Full=C->U-editing enzyme APOBEC-1; AltName: Full=Apolipoprotein B mRNA-editing enzyme 1 [Rattus norvegicus]