Gene/Proteome Database (LMPD)

LMPD ID
LMP012508
Gene ID
25413
Species
Rattus norvegicus (Rat)
Gene Name
carnitine palmitoyltransferase 2
Gene Symbol
Cpt2
Synonyms
CPTII;
Alternate Names
carnitine O-palmitoyltransferase 2, mitochondrial; CPT II; carnitine palmitoyltransferase II;
Chromosome
5
Map Location
5q35
EC Number
2.3.1.21
Summary
inner mitochondrial membrane protein that converts acylcarnitine to acyl-CoA [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cpt2

Proteins

carnitine O-palmitoyltransferase 2, mitochondrial precursor
Refseq ID NP_037062
Protein GI 6978705
UniProt ID P18886
mRNA ID NM_012930
Length 658
MMPRLLFRAWPRCPSLVLGAPSRPLSAVSGPDDYLQHSIVPTMHYQDSLPRLPIPKLEDTMKRYLNAQKPLLDDSQFRRTEALCKNFETGVGKELHAHLLAQDKQNKHTSYISGPWFDMYLTARDSIVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAVRFLKTLQAGLLEPEVFHLNPSKSDTDAFKRLIRFVPPSLSWYGAYLVNAYPLDMSQYFRLFNSTRIPRPNRDELFTDTKARHLLVLRKGHFYVFDVLDQDGNIVNPLEIQAHLKYILSDSSPVPEFPVAYLTSENRDVWAELRQKLIFDGNEETLKKVDSAVFCLCLDDFPMKDLIHLSHTMLHGDGTNRWFDKSFNLIVAEDGTAAVHFEHSWGDGVAVLRFFNEVFRDSTQTPAITPQSQPAATNSSASVETLSFNLSGALKAGITAAKEKFDTTVKTLSIDSIQFQRGGKEFLKKKQLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASIFTKRCSEAFVRDPSKHSVGELQHMMAECSKYHGQLTKEAAMGQGFDRHLYALRYLATARGLNLPELYLDPAYQQMNHNILSTSTLNSPAVSLGGFAPVVPDGFGIAYAVHDDWIGCNVSSYSGRNAREFLHCVQKCLEDIFDALEGKAIKT
transit_peptide: 1..25 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P18886.1) calculated_mol_wt: 2866 peptide sequence: MMPRLLFRAWPRCPSLVLGAPSRPL mat_peptide: 26..658 product: Carnitine O-palmitoyltransferase 2, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P18886.1) calculated_mol_wt: 71263 peptide sequence: SAVSGPDDYLQHSIVPTMHYQDSLPRLPIPKLEDTMKRYLNAQKPLLDDSQFRRTEALCKNFETGVGKELHAHLLAQDKQNKHTSYISGPWFDMYLTARDSIVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAVRFLKTLQAGLLEPEVFHLNPSKSDTDAFKRLIRFVPPSLSWYGAYLVNAYPLDMSQYFRLFNSTRIPRPNRDELFTDTKARHLLVLRKGHFYVFDVLDQDGNIVNPLEIQAHLKYILSDSSPVPEFPVAYLTSENRDVWAELRQKLIFDGNEETLKKVDSAVFCLCLDDFPMKDLIHLSHTMLHGDGTNRWFDKSFNLIVAEDGTAAVHFEHSWGDGVAVLRFFNEVFRDSTQTPAITPQSQPAATNSSASVETLSFNLSGALKAGITAAKEKFDTTVKTLSIDSIQFQRGGKEFLKKKQLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASIFTKRCSEAFVRDPSKHSVGELQHMMAECSKYHGQLTKEAAMGQGFDRHLYALRYLATARGLNLPELYLDPAYQQMNHNILSTSTLNSPAVSLGGFAPVVPDGFGIAYAVHDDWIGCNVSSYSGRNAREFLHCVQKCLEDIFDALEGKAIKT

Gene Information

Entrez Gene ID
25413
Gene Name
carnitine palmitoyltransferase 2
Gene Symbol
Cpt2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 IEA:UniProtKB-KW C mitochondrial inner membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0004095 IDA:RGD F carnitine O-palmitoyltransferase activity
GO:0006635 TAS:RGD P fatty acid beta-oxidation
GO:0015909 TAS:RGD P long-chain fatty acid transport

KEGG Pathway Links

KEGG Pathway ID Description
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6111 mitochondrial L-carnitine shuttle

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine palmitoyltransferase 2
Protein Entry
CPT2_RAT
UniProt ID
P18886
Species
Rat

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine.
Similarity Belongs to the carnitine/choline acetyltransferase family
Subcellular Location Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .

Identical and Related Proteins

Unique RefSeq proteins for LMP012508 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978705 RefSeq NP_037062 658 carnitine O-palmitoyltransferase 2, mitochondrial precursor

Identical Sequences to LMP012508 proteins

Reference Database Accession Length Protein Name
GI:6978705 EMBL CBN63524.1 658 unnamed protein product [Rattus norvegicus]
GI:6978705 EMBL CBN60632.1 658 unnamed protein product [Rattus norvegicus]
GI:6978705 EMBL CBN65241.1 658 unnamed protein product [Rattus norvegicus]
GI:6978705 GenBank AAB02339.1 658 carnitine palmitoyltransferase II [Rattus norvegicus]

Related Sequences to LMP012508 proteins

Reference Database Accession Length Protein Name
GI:6978705 EMBL CBN63524.1 658 unnamed protein product [Rattus norvegicus]
GI:6978705 GenBank AAB02339.1 658 carnitine palmitoyltransferase II [Rattus norvegicus]
GI:6978705 SwissProt P18886.1 658 RecName: Full=Carnitine O-palmitoyltransferase 2, mitochondrial; AltName: Full=Carnitine palmitoyltransferase II; Short=CPT II; Flags: Precursor [Rattus norvegicus]