Gene/Proteome Database (LMPD)

LMPD ID
LMP012509
Gene ID
25427
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 51
Gene Symbol
Cyp51
Synonyms
Cyp51a1; RATCP14DM;
Alternate Names
lanosterol 14-alpha demethylase; LDM; CYPLI; P450LI; P45014DM; P450-14DM; cytochrome P450LI; cytochrome P45014DM; cytochrome P450 51A1; cytochrome P450-14DM; sterol 14-alpha demethylase; cytochrome P450, subfamily 51; Cytochrom P450 Lanosterol 14 alpha-demethylase; cytochrome P450 Lanosterol 14 alpha-demethylase;
Chromosome
4
Map Location
4q13
EC Number
1.14.13.70
Summary
gene amplification is detected in some endometrial carcinomas [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp51

Proteins

lanosterol 14-alpha demethylase
Refseq ID NP_037073
Protein GI 6978751
UniProt ID Q64654
mRNA ID NM_012941
Length 503
MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAKEYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTTMIHTPENPVIRYKRRSK

Gene Information

Entrez Gene ID
25427
Gene Name
cytochrome P450, family 51
Gene Symbol
Cyp51
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0020037 IEA:Ensembl F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008398 IDA:RGD F sterol 14-demethylase activity
GO:0033488 IDA:RGD P cholesterol biosynthetic process via 24,25-dihydrolanosterol
GO:0070988 IDA:GOC P demethylation
GO:0045540 TAS:RGD P regulation of cholesterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
rno01100 Metabolic pathways
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953258 Biological oxidations
5953924 Cholesterol biosynthesis
5953485 Cytochrome P450 - arranged by substrate type
5953932 Endogenous sterols
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953326 Phase 1 - Functionalization of compounds
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 51
Protein Entry
CP51A_RAT
UniProt ID
Q64654
Species
Rat

Comments

Comment Type Description
Catalytic Activity A 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Function Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Pathway Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.
Similarity Belongs to the cytochrome P450 family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane .

Identical and Related Proteins

Unique RefSeq proteins for LMP012509 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978751 RefSeq NP_037073 503 lanosterol 14-alpha demethylase

Identical Sequences to LMP012509 proteins

Reference Database Accession Length Protein Name
GI:6978751 GenBank AAH87033.1 503 Cytochrome P450, subfamily 51 [Rattus norvegicus]
GI:6978751 GenBank EDL84353.1 503 cytochrome P450, subfamily 51 [Rattus norvegicus]
GI:6978751 GenBank AEL93538.1 503 Sequence 155 from patent US 7982096
GI:6978751 SwissProt Q64654.1 503 RecName: Full=Lanosterol 14-alpha demethylase; Short=LDM; AltName: Full=CYPLI; AltName: Full=Cytochrome P450 51A1; AltName: Full=Cytochrome P450-14DM; Short=Cytochrome P45014DM; AltName: Full=Cytochrome P450LI; AltName: Full=Sterol 14-alpha demethylase [Rattus norvegicus]

Related Sequences to LMP012509 proteins

Reference Database Accession Length Protein Name
GI:6978751 DBBJ BAA20354.1 503 lanosterol 14-demethylase [Rattus norvegicus]
GI:6978751 GenBank EDL84353.1 503 cytochrome P450, subfamily 51 [Rattus norvegicus]
GI:6978751 SwissProt Q64654.1 503 RecName: Full=Lanosterol 14-alpha demethylase; Short=LDM; AltName: Full=CYPLI; AltName: Full=Cytochrome P450 51A1; AltName: Full=Cytochrome P450-14DM; Short=Cytochrome P45014DM; AltName: Full=Cytochrome P450LI; AltName: Full=Sterol 14-alpha demethylase [Rattus norvegicus]