Gene/Proteome Database (LMPD)

LMPD ID
LMP012511
Gene ID
25429
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 7, subfamily b, polypeptide 1
Gene Symbol
Cyp7b1
Alternate Names
25-hydroxycholesterol 7-alpha-hydroxylase; HCT-1; cytochrome P450 7B1; oxysterol 7-alpha-hydroxylase; hippocampal transcript 1 protein; cytochrome P450, subfamily 7B, polypeptide 1;
Chromosome
2
Map Location
2q24
EC Number
1.14.13.100
Summary
member of the p450 subfamily of cholesterol metabolizing enzymes that performs 7alpha-hydroxylation of 27-hydroxycholesterol in a bile synthesis pathway alternative to the classical cholesterol disposal pathway [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp7b1

Proteins

25-hydroxycholesterol 7-alpha-hydroxylase
Refseq ID NP_062011
Protein GI 158186667
UniProt ID Q63688
mRNA ID NM_019138
Length 507
MEGATTPDAASPGPLSLLGLLFAVTLLLPVLFLLTRRTRRPCEPPLIKGWIPYLGMALKFWKDPLAFLQTLQRQCGDTFTVLLGGKYITFVLNPFQYQYVMKNPKQLSFEKFSRRLSAKAFSVKKLLTNDDLSNDIHRGYLLLQGKSLDGLLETMIQEVKEIFESRLLKLTDWNTARVFDFCSSLVFEITFTTIYGKILAANKKQIISELRDDFLKFDDHFPYLVSDIPIQLLRNAEFMQKKIIKCLTPEKVAQMQRRSEIVQERQEMLKKYYGHEEFEIGAHHLGLLWASLANTIPAMFWAMYYLLQHPEAMEVLRDEIDSFLQSTGQKKGPGISVHFTREQLDSLVCLESAILEVLRLCSYSSIIREVQEDMDFSSESRSYRLRKGDFVAVFPPMIHNDPEVFDAPKDFRFDRFVEDGKKKTTFFKGGKKLKSYIIPFGLGTSKCPGRYFAINEMKLLVIILLTYFDLEVIDTKPIGLNHSRMFLGIQHPDSDISFRYKAKSWRS

Gene Information

Entrez Gene ID
25429
Gene Name
cytochrome P450, family 7, subfamily b, polypeptide 1
Gene Symbol
Cyp7b1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0033783 IEA:UniProtKB-EC F 25-hydroxycholesterol 7alpha-hydroxylase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008396 TAS:RGD F oxysterol 7-alpha-hydroxylase activity
GO:0006699 TAS:RGD P bile acid biosynthetic process
GO:0008203 TAS:RGD P cholesterol metabolic process
GO:0007623 IDA:RGD P circadian rhythm
GO:0007613 IDA:RGD P memory
GO:0051591 IEP:RGD P response to cAMP
GO:0042493 IEP:RGD P response to drug

KEGG Pathway Links

KEGG Pathway ID Description
ko00120 Primary bile acid biosynthesis
rno00120 Primary bile acid biosynthesis
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 7, subfamily b, polypeptide 1
Protein Entry
CP7B1_RAT
UniProt ID
Q63688
Species
Rat

Comments

Comment Type Description
Catalytic Activity Cholest-5-ene-3-beta,25-diol + NADPH + O(2) = cholest-5-ene-3-beta,7-alpha,25-triol + NADP(+) + H(2)O.
Catalytic Activity Cholest-5-ene-3-beta,27-diol + NADPH + O(2) = cholest-5-ene-3-beta,7-alpha,27-triol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Pathway Lipid metabolism; bile acid biosynthesis.
Similarity Belongs to the cytochrome P450 family
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Highly expressed in brain; also expressed in liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP012511 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158186667 RefSeq NP_062011 507 25-hydroxycholesterol 7-alpha-hydroxylase

Identical Sequences to LMP012511 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012511 proteins

Reference Database Accession Length Protein Name
GI:158186667 DBBJ BAE24236.1 507 unnamed protein product [Mus musculus]
GI:158186667 GenBank EDM01054.1 507 cytochrome P450, family 7, subfamily b, polypeptide 1 [Rattus norvegicus]
GI:158186667 RefSeq NP_031851.3 507 25-hydroxycholesterol 7-alpha-hydroxylase [Mus musculus]