Gene/Proteome Database (LMPD)

LMPD ID
LMP012515
Gene ID
25513
Species
Rattus norvegicus (Rat)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene Symbol
Pik3r1
Synonyms
PI3KA;
Alternate Names
phosphatidylinositol 3-kinase regulatory subunit alpha; ptdIns-3-kinase p85-alpha; PI3-kinase p85 subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);
Chromosome
2
Map Location
2q12

Proteins

phosphatidylinositol 3-kinase regulatory subunit alpha
Refseq ID NP_037137
Protein GI 6981358
UniProt ID Q63787
mRNA ID NM_013005
Length 724
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPVLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDPPSVDLDVFDEHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQEVPSSEDYIQLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFPAASSDNTEHLIKAVELLISAEWSERQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNDTIKIFEEQCHPQERYSKDYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVDDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR

Gene Information

Entrez Gene ID
25513
Gene Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene Symbol
Pik3r1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0016020 IDA:RGD C membrane
GO:0043005 IDA:RGD C neuron projection
GO:0005634 IDA:RGD C nucleus
GO:0005942 IDA:RGD C phosphatidylinositol 3-kinase complex
GO:0005943 ISS:UniProtKB C phosphatidylinositol 3-kinase complex, class IA
GO:0005886 IDA:RGD C plasma membrane
GO:0043234 IDA:RGD C protein complex
GO:0016303 TAS:RGD F 1-phosphatidylinositol-3-kinase activity
GO:0046935 IDA:RGD F 1-phosphatidylinositol-3-kinase regulator activity
GO:0051117 IPI:RGD F ATPase binding
GO:0043125 ISS:UniProtKB F ErbB-3 class receptor binding
GO:0005516 IPI:RGD F calmodulin binding
GO:0030331 IPI:RGD F estrogen receptor binding
GO:0005158 ISS:UniProtKB F insulin receptor binding
GO:0043560 ISS:UniProtKB F insulin receptor substrate binding
GO:0005159 ISS:UniProtKB F insulin-like growth factor receptor binding
GO:0043548 IPI:RGD F phosphatidylinositol 3-kinase binding
GO:0035014 ISS:UniProtKB F phosphatidylinositol 3-kinase regulator activity
GO:0051219 IPI:RGD F phosphoprotein binding
GO:0005161 IPI:RGD F platelet-derived growth factor receptor binding
GO:0008022 IDA:RGD F protein C-terminus binding
GO:0019904 IPI:RGD F protein domain specific binding
GO:0019901 IPI:RGD F protein kinase binding
GO:0005102 IPI:RGD F receptor binding
GO:0030971 IPI:RGD F receptor tyrosine kinase binding
GO:0031625 IPI:RGD F ubiquitin protein ligase binding
GO:0007568 IEP:RGD P aging
GO:0071398 IEP:RGD P cellular response to fatty acid
GO:0032869 IEP:RGD P cellular response to insulin stimulus
GO:0006006 IMP:RGD P glucose metabolic process
GO:0008286 ISS:UniProtKB P insulin receptor signaling pathway
GO:0048009 ISS:UniProtKB P insulin-like growth factor receptor signaling pathway
GO:0045776 IMP:RGD P negative regulation of blood pressure
GO:0022408 IMP:RGD P negative regulation of cell-cell adhesion
GO:0010459 IMP:RGD P negative regulation of heart rate
GO:0010656 IMP:RGD P negative regulation of muscle cell apoptotic process
GO:0045861 IMP:RGD P negative regulation of proteolysis
GO:0048662 IMP:RGD P negative regulation of smooth muscle cell proliferation
GO:0046854 ISS:UniProtKB P phosphatidylinositol phosphorylation
GO:0036092 IDA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0030335 IMP:RGD P positive regulation of cell migration
GO:0010628 IMP:RGD P positive regulation of gene expression
GO:0045663 IMP:RGD P positive regulation of myoblast differentiation
GO:0001934 IMP:RGD P positive regulation of protein phosphorylation
GO:0043551 IDA:RGD P regulation of phosphatidylinositol 3-kinase activity
GO:0043200 IEP:RGD P response to amino acid
GO:0051591 IDA:RGD P response to cAMP
GO:0071548 IEP:RGD P response to dexamethasone
GO:0042493 IEP:RGD P response to drug
GO:0032355 IEP:RGD P response to estradiol
GO:0045471 IEP:RGD P response to ethanol
GO:0070542 IEP:RGD P response to fatty acid
GO:0009750 IEP:RGD P response to fructose
GO:0051384 IDA:RGD P response to glucocorticoid
GO:0070848 IEP:RGD P response to growth factor
GO:0032868 IDA:RGD P response to insulin
GO:0010040 IEP:RGD P response to iron(II) ion
GO:0007584 IEP:RGD P response to nutrient
GO:0032570 IEP:RGD P response to progesterone
GO:0033574 IEP:RGD P response to testosterone
GO:0001878 IEP:RGD P response to yeast

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko04960 Aldosterone-regulated sodium reabsorption
rno04960 Aldosterone-regulated sodium reabsorption
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04210 Apoptosis
rno04210 Apoptosis
ko04662 B cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
ko05100 Bacterial invasion of epithelial cells
rno05100 Bacterial invasion of epithelial cells
ko04973 Carbohydrate digestion and absorption
rno04973 Carbohydrate digestion and absorption
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko05220 Chronic myeloid leukemia
rno05220 Chronic myeloid leukemia
ko05210 Colorectal cancer
rno05210 Colorectal cancer
ko05213 Endometrial cancer
rno05213 Endometrial cancer
ko05169 Epstein-Barr virus infection
rno05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04664 Fc epsilon RI signaling pathway
rno04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
rno04510 Focal adhesion
rno04068 FoxO signaling pathway
ko05214 Glioma
rno05214 Glioma
rno04066 HIF-1 signaling pathway
ko05166 HTLV-I infection
rno05166 HTLV-I infection
rno05161 Hepatitis B
ko05160 Hepatitis C
rno05160 Hepatitis C
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko05164 Influenza A
rno05164 Influenza A
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway
ko04630 Jak-STAT signaling pathway
rno04630 Jak-STAT signaling pathway
ko04670 Leukocyte transendothelial migration
rno04670 Leukocyte transendothelial migration
ko05162 Measles
rno05162 Measles
ko05218 Melanoma
rno05218 Melanoma
ko04650 Natural killer cell mediated cytotoxicity
rno04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
rno04722 Neurotrophin signaling pathway
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko05212 Pancreatic cancer
rno05212 Pancreatic cancer
rno05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04611 Platelet activation
ko04914 Progesterone-mediated oocyte maturation
rno04914 Progesterone-mediated oocyte maturation
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko05215 Prostate cancer
rno05215 Prostate cancer
ko05205 Proteoglycans in cancer
rno05205 Proteoglycans in cancer
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton
ko05211 Renal cell carcinoma
rno05211 Renal cell carcinoma
ko04550 Signaling pathways regulating pluripotency of stem cells
rno04550 Signaling pathways regulating pluripotency of stem cells
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko04660 T cell receptor signaling pathway
rno04660 T cell receptor signaling pathway
ko04668 TNF signaling pathway
rno04668 TNF signaling pathway
rno04919 Thyroid hormone signaling pathway
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
rno05145 Toxoplasmosis
ko04930 Type II diabetes mellitus
rno04930 Type II diabetes mellitus
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway
ko05203 Viral carcinogenesis
rno05203 Viral carcinogenesis
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway
ko04150 mTOR signaling pathway
rno04150 mTOR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953415 Adaptive Immune System
5953413 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
5953991 CD28 co-stimulation
5953990 CD28 dependent PI3K/Akt signaling
5953650 Cell surface interactions at the vascular wall
5954063 Cell-Cell communication
5954570 Constitutive PI3K/AKT Signaling in Cancer
5953992 Costimulation by the CD28 family
5953536 Cytokine Signaling in Immune system
5953408 DAP12 interactions
5953407 DAP12 signaling
5953253 Disease
5954035 Downstream TCR signaling
5953396 Downstream signal transduction
5953994 Downstream signaling events of B Cell Receptor (BCR)
5953399 Downstream signaling of activated FGFR
5953417 Fc epsilon receptor (FCERI) signaling
5953784 Fcgamma receptor (FCGR) dependent phagocytosis
5953641 G alpha (12/13) signalling events
5953653 G alpha (q) signalling events
5953884 GAB1 signalosome
5954278 GP1b-IX-V activation signalling
5953642 GPCR downstream signaling
5953651 GPVI-mediated activation cascade
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953645 Hemostasis
5953430 IGF1R signaling cascade
5953428 IRS-mediated signalling
5953425 IRS-related events
5953429 IRS-related events triggered by IGF1R
5953410 Immune System
5953409 Innate Immune System
5953422 Insulin receptor signalling cascade
5954000 Interleukin receptor SHC signaling
5953534 Interleukin-2 signaling
5954001 Interleukin-3, 5 and GM-CSF signaling
5954308 Interleukin-7 signaling
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953394 NGF signalling via TRKA from the plasma membrane
5954128 Nephrin interactions
5954478 PI Metabolism
5953885 PI-3K cascade
5953432 PI3K Cascade
5953996 PI3K events in ERBB2 signaling
5953995 PI3K events in ERBB4 signaling
5953997 PI3K/AKT Signaling in Cancer
5953989 PI3K/AKT activation
5953993 PIP3 activates AKT signaling
5953474 Phospholipid metabolism
5953644 Platelet activation, signaling and aggregation
5954358 Regulation of signaling by CBL
5953998 Role of LAT2/NTAL/LAB on calcium mobilization
5953783 Role of phospholipids in phagocytosis
5953381 Signal Transduction
5953403 Signaling by EGFR
5953404 Signaling by EGFR in Cancer
5953406 Signaling by ERBB2
5953540 Signaling by ERBB4
5953400 Signaling by FGFR
5953401 Signaling by FGFR in disease
5954512 Signaling by FGFR mutants
5954510 Signaling by FGFR1 fusion mutants
5954511 Signaling by FGFR1 mutants
5953391 Signaling by GPCR
5953423 Signaling by Insulin receptor
5953535 Signaling by Interleukins
5953397 Signaling by PDGF
5953541 Signaling by SCF-KIT
5953431 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5953420 Signaling by VEGF
5954412 Signaling by constitutively active EGFR
5953414 Signaling by the B Cell Receptor (BCR)
5953395 Signalling by NGF
5954499 Synthesis of PIPs at the plasma membrane
5954036 TCR signaling
5954054 Tie2 Signaling
5953419 VEGFA-VEGFR2 Pathway

Domain Information

InterPro Annotations

Accession Description
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein
IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR001452 SH3_domain
IPR011511 Variant SH3 domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Protein Entry
P85A_RAT
UniProt ID
Q63787
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=p85-alpha; IsoId=Q63787-1; Sequence=Displayed; Name=p55-alpha; IsoId=Q63787-2; Sequence=VSP_004709, VSP_004710; Name=p50-alpha; IsoId=Q63787-3; Sequence=VSP_004711, VSP_004712;
Domain The SH3 domain mediates the binding to CBLB
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity)
Interaction A0MZ67:-; NbExp=2; IntAct=EBI-518443, EBI-1392040; P21575:Dnm1; NbExp=2; IntAct=EBI-518443, EBI-80070; P62813:Gabra1; NbExp=4; IntAct=EBI-518443, EBI-6258192; P35570:Irs1; NbExp=3; IntAct=EBI-518443, EBI-520230; Q91V33:Khdrbs1; NbExp=2; IntAct=EBI-518443, EBI-518436; P18545:PDE6G (xeno); NbExp=2; IntAct=EBI-518443, EBI-2622029;
Ptm Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR and ERBB4 (By similarity)
Ptm Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation
Similarity Belongs to the PI3K p85 subunit family
Similarity Contains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
Similarity Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Similarity Contains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subunit Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with phosphorylated LAT, LAX1, TRAT1 and LIME1 upon TCR and/or activation. Interacts with phosphorylated TOM1L1. Interacts with CBLB. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine- phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with NISCH, SOCS7 and HCST (By similarity). Interacts with IRS1 and phosphorylated IRS4. Interacts with RUFY3. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated) (Probable). Interacts with AXL, FASLG, FER, FGR, HCK, KIT and BCR (By similarity). Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity (By similarity). Interacts with NTRK1 (phosphorylated upon ligand-binding) (By similarity). Interacts with PTK2/FAK1. {ECO:0000250, ECO:0000269|PubMed:8628286, ECO:0000269|PubMed:8824286, ECO:0000305}.
Tissue Specificity The P85-alpha isoform is widely expressed. Expression of the P55-alpha isoform is highest in brain and skeletal muscle. The P50-alpha isoform is abundant in liver with lower levels in brain and muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP012515 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981358 RefSeq NP_037137 724 phosphatidylinositol 3-kinase regulatory subunit alpha

Identical Sequences to LMP012515 proteins

Reference Database Accession Length Protein Name
GI:6981358 DBBJ BAA18932.1 724 phosphatidylinositol 3-kinase p85 alpha subunit [Rattus norvegicus]
GI:6981358 SwissProt Q63787.1 724 RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha; Short=PI3-kinase regulatory subunit alpha; Short=PI3K regulatory subunit alpha; Short=PtdIns-3-kinase regulatory subunit alpha; AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Short=PI3-kinase subunit p85-alpha; Short=PtdIns-3-kinase regulatory subunit p85-alpha [Rattus norvegicus]

Related Sequences to LMP012515 proteins

Reference Database Accession Length Protein Name
GI:6981358 DBBJ BAA18932.1 724 phosphatidylinositol 3-kinase p85 alpha subunit [Rattus norvegicus]
GI:6981358 PRF - 724 phosphatidylinositol 3-kinase:SUBUNIT=55kD regulatory [Rattus norvegicus]
GI:6981358 SwissProt Q63787.1 724 RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha; Short=PI3-kinase regulatory subunit alpha; Short=PI3K regulatory subunit alpha; Short=PtdIns-3-kinase regulatory subunit alpha; AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Short=PI3-kinase subunit p85-alpha; Short=PtdIns-3-kinase regulatory subunit p85-alpha [Rattus norvegicus]