Gene/Proteome Database (LMPD)

LMPD ID
LMP012521
Gene ID
25527
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
Ptgis
Synonyms
PGIS;
Alternate Names
prostacyclin synthase; prostaglandin I2 synthase;
Chromosome
3
Map Location
3q42
EC Number
5.3.99.4
Summary
catalyzes the conversion of prostaglandin H2 to prostacyclin in prostaglandin biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ptgis

Proteins

prostacyclin synthase precursor
Refseq ID NP_113745
Protein GI 13928752
UniProt ID Q62969
mRNA ID NM_031557
Length 501
MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHALEFGKDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWDLRTRLDFHPYAIFLMERIFDLQLPNFNPSEEKARMKPTLMHKDLQALTEAMYTNLRTVLLGDSTEGGSGWQEKGLLEFSYSSLLSAGYLTLYGVEASPRTHESQALDRDHSADVFRTFRQLDLMLPKLARGSLSVGDKDHACSVKSRLWKLLSPAGLASRADRSSWLESYLRHLEEMGVSEDMQARALVLQLWATQGNMGPTAFWLLLFLLKNPEALDAVHAELKRIVWQAEKPVLQMTALPQKILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADRREFSLRRGDRLLLFPFLSPQKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAINSIKQFVVLLLTHFDLELVSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRTRL
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2777 peptide sequence: MSWAALLGLLAVLLLLLLLLSRRRA

Gene Information

Entrez Gene ID
25527
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
Ptgis
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005901 ISS:UniProtKB C caveola
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0005615 IDA:RGD C extracellular space
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 ISS:UniProtKB C nucleus
GO:0020037 IBA:RefGenome F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:InterPro F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008116 IDA:RGD F prostaglandin-I synthase activity
GO:0071456 ISS:UniProtKB P cellular response to hypoxia
GO:0071347 ISS:UniProtKB P cellular response to interleukin-1
GO:0071354 ISS:UniProtKB P cellular response to interleukin-6
GO:0050728 ISS:UniProtKB P negative regulation of inflammatory response
GO:0032088 ISS:UniProtKB P negative regulation of NF-kappaB transcription factor activity
GO:0045019 ISS:UniProtKB P negative regulation of nitric oxide biosynthetic process
GO:0045766 ISS:UniProtKB P positive regulation of angiogenesis
GO:1900119 ISS:UniProtKB P positive regulation of execution phase of apoptosis
GO:0035360 ISS:UniProtKB P positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0001516 ISS:UniProtKB P prostaglandin biosynthetic process
GO:0042981 IBA:RefGenome P regulation of apoptotic process
GO:0001666 IMP:RGD P response to hypoxia

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
IPR002403 Cytochrome P450, E-class, group IV
IPR027286 Prostacyclin synthase

UniProt Annotations

Entry Information

Gene Name
prostaglandin I2 (prostacyclin) synthase
Protein Entry
PTGIS_RAT
UniProt ID
Q62969
Species
Rat

Comments

Comment Type Description
Catalytic Activity (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11- alpha,15-dihydroxyprosta-5,13-dienoate.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)
Similarity Belongs to the cytochrome P450 family
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012521 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13928752 RefSeq NP_113745 501 prostacyclin synthase precursor

Identical Sequences to LMP012521 proteins

Reference Database Accession Length Protein Name
GI:13928752 GenBank AAB02322.1 501 prostacyclin synthase [Rattus norvegicus]
GI:13928752 GenBank AAH61814.1 501 Prostaglandin I2 (prostacyclin) synthase [Rattus norvegicus]
GI:13928752 SwissProt Q62969.1 501 RecName: Full=Prostacyclin synthase; AltName: Full=Prostaglandin I2 synthase [Rattus norvegicus]

Related Sequences to LMP012521 proteins

Reference Database Accession Length Protein Name
GI:13928752 GenBank AAB02322.1 501 prostacyclin synthase [Rattus norvegicus]
GI:13928752 GenBank AAH61814.1 501 Prostaglandin I2 (prostacyclin) synthase [Rattus norvegicus]
GI:13928752 SwissProt Q62969.1 501 RecName: Full=Prostacyclin synthase; AltName: Full=Prostaglandin I2 synthase [Rattus norvegicus]