Gene/Proteome Database (LMPD)

LMPD ID
LMP012525
Gene ID
25549
Species
Rattus norvegicus (Rat)
Gene Name
solute carrier family 18 (vesicular monoamine transporter), member 2
Gene Symbol
Slc18a2
Synonyms
MNAT; VMAT2; VMAT-2;
Alternate Names
synaptic vesicular amine transporter; VAT2; monoamine transporter; vesicular amine transporter 2; solute carrier family 18, member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2);
Chromosome
1
Map Location
1q55
Summary
transports N-methyl-4-phenylpyridinium (MPP+), a neurotoxin metabolite associated with Parkinson's disease [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Slc18a2

Proteins

synaptic vesicular amine transporter
Refseq ID NP_037163
Protein GI 6981546
UniProt ID Q01827
mRNA ID NM_013031
Length 515
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNVQSYPIGDDEESESD

Gene Information

Entrez Gene ID
25549
Gene Name
solute carrier family 18 (vesicular monoamine transporter), member 2
Gene Symbol
Slc18a2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043679 IDA:RGD C axon terminus
GO:0044297 IDA:RGD C cell body
GO:0042995 IDA:RGD C cell projection
GO:0005737 IDA:RGD C cytoplasm
GO:0031045 IDA:RGD C dense core granule
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043005 IDA:RGD C neuron projection
GO:0043025 IDA:RGD C neuronal cell body
GO:0008021 IDA:RGD C synaptic vesicle
GO:0030672 IDA:RGD C synaptic vesicle membrane
GO:0043195 IDA:RGD C terminal bouton
GO:0005275 IDA:RGD F amine transmembrane transporter activity
GO:0008144 IPI:RGD F drug binding
GO:0015238 IEA:InterPro F drug transmembrane transporter activity
GO:0019899 IPI:RGD F enzyme binding
GO:0031072 IPI:RGD F heat shock protein binding
GO:0015222 IDA:RGD F serotonin transmembrane transporter activity
GO:0007568 IDA:RGD P aging
GO:0071242 IEP:RGD P cellular response to ammonium ion
GO:0035690 IDA:RGD P cellular response to drug
GO:0016265 IEA:Ensembl P death
GO:0032456 IEP:RGD P endocytic recycling
GO:0042593 IDA:RGD P glucose homeostasis
GO:0030073 IDA:RGD P insulin secretion
GO:0007626 IEA:Ensembl P locomotory behavior
GO:0015844 IDA:RGD P monoamine transport
GO:0051589 IMP:RGD P negative regulation of neurotransmitter transport
GO:0006836 IDA:RGD P neurotransmitter transport
GO:0009791 IEA:Ensembl P post-embryonic development
GO:0001975 IEP:RGD P response to amphetamine
GO:0042220 IEP:RGD P response to cocaine
GO:0051412 IEP:RGD P response to corticosterone
GO:0042493 IEP:RGD P response to drug
GO:0009635 IEP:RGD P response to herbicide
GO:0010038 IEP:RGD P response to metal ion
GO:0042594 IEP:RGD P response to starvation
GO:0010043 IEP:RGD P response to zinc ion
GO:0006837 IDA:GOC P serotonin transport
GO:0015842 IMP:RGD P synaptic vesicle amine transport

KEGG Pathway Links

KEGG Pathway ID Description
ko05034 Alcoholism
rno05034 Alcoholism
ko05031 Amphetamine addiction
rno05031 Amphetamine addiction
ko05030 Cocaine addiction
rno05030 Cocaine addiction
ko04728 Dopaminergic synapse
rno04728 Dopaminergic synapse
rno05012 Parkinson's disease
rno04726 Serotonergic synapse
ko04721 Synaptic vesicle cycle
rno04721 Synaptic vesicle cycle

REACTOME Pathway Links

REACTOME Pathway ID Description
5954117 Dopamine Neurotransmitter Release Cycle
5954108 Na+/Cl- dependent neurotransmitter transporters
5953277 Neuronal System
5953279 Neurotransmitter Release Cycle
5954116 Norepinephrine Neurotransmitter Release Cycle
5953264 SLC-mediated transmembrane transport
5954160 Serotonin Neurotransmitter Release Cycle
5953265 Transmembrane transport of small molecules
5953276 Transmission across Chemical Synapses
5953895 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Domain Information

InterPro Annotations

Accession Description
IPR011701 Major facilitator superfamily
IPR020846 Major facilitator superfamily domain
IPR004734 Multidrug resistance protein

UniProt Annotations

Entry Information

Gene Name
solute carrier family 18 (vesicular monoamine transporter), member 2
Protein Entry
VMAT2_RAT
UniProt ID
Q01827
Species
Rat

Comments

Comment Type Description
Function Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.
Similarity Belongs to the major facilitator superfamily. Vesicular transporter family
Subcellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Subunit Interacts with SLC6A3
Tissue Specificity Brainstem and stomach.

Identical and Related Proteins

Unique RefSeq proteins for LMP012525 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981546 RefSeq NP_037163 515 synaptic vesicular amine transporter

Identical Sequences to LMP012525 proteins

Reference Database Accession Length Protein Name
GI:6981546 GenBank AAA41627.1 515 monoamine transporter [Rattus norvegicus]
GI:6981546 GenBank EDL94556.1 515 solute carrier family 18 (vesicular monoamine), member 2, isoform CRA_a [Rattus norvegicus]
GI:6981546 GenBank EDL94557.1 515 solute carrier family 18 (vesicular monoamine), member 2, isoform CRA_a [Rattus norvegicus]
GI:6981546 RefSeq XP_006231726.1 515 PREDICTED: synaptic vesicular amine transporter isoform X1 [Rattus norvegicus]

Related Sequences to LMP012525 proteins

Reference Database Accession Length Protein Name
GI:6981546 GenBank AAA41627.1 515 monoamine transporter [Rattus norvegicus]
GI:6981546 GenBank EDL94557.1 515 solute carrier family 18 (vesicular monoamine), member 2, isoform CRA_a [Rattus norvegicus]
GI:6981546 RefSeq XP_006231726.1 515 PREDICTED: synaptic vesicular amine transporter isoform X1 [Rattus norvegicus]