Gene/Proteome Database (LMPD)
LMPD ID
LMP012527
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
tenascin R
Gene Symbol
Synonyms
J1NRM;
Alternate Names
tenascin-R; TN-R; janusin; restrictin; tenascin R (restrictin, janusin); neural recognition molecule J1-160/180; Tenascin-R (Restrictin janusin J1-160/180); Tenascin-R (Restrictin, janusin, J1-160/180);
Chromosome
13
Map Location
13q23
Summary
an extracellular matrix protein; involved in regulating neurite outgrowth [RGD, Feb 2006]
Orthologs
Proteins
| tenascin-R precursor | |
|---|---|
| Refseq ID | NP_037177 |
| Protein GI | 6981668 |
| UniProt ID | Q05546 |
| mRNA ID | NM_013045 |
| Length | 1356 |
| MGIEGETVVLKNMLIGVNLILLGSMLKPSECRLEVTTERVQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDVSAEDDTLAEYTGQTSDHESQVTFTHKINLPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVTPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPSLGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFTPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARGPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFDYYEYPIDHPSGRLDSSVVPNTVTEFTITRLYPASQYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPLVSGTIATNFSTLLDPPANLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNYHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF | |
| sig_peptide: 1..31 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q05546.1) calculated_mol_wt: 3303 peptide sequence: MGIEGETVVLKNMLIGVNLILLGSMLKPSEC mat_peptide: 32..1356 product: Tenascin-R experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q05546.1) calculated_mol_wt: 146087 peptide sequence: RLEVTTERVQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDVSAEDDTLAEYTGQTSDHESQVTFTHKINLPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVTPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPSLGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFTPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARGPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFDYYEYPIDHPSGRLDSSVVPNTVTEFTITRLYPASQYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPLVSGTIATNFSTLLDPPANLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNYHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005578 | IDA:RGD | C | proteinaceous extracellular matrix |
| GO:0005178 | IPI:RGD | F | integrin binding |
| GO:0007155 | IEA:UniProtKB-KW | P | cell adhesion |
| GO:0007162 | IDA:RGD | P | negative regulation of cell adhesion |
| GO:0007399 | TAS:RGD | P | nervous system development |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR013111 | EGF-like domain, extracellular |
| IPR013032 | EGF-like, conserved site |
| IPR000742 | Epidermal growth factor-like domain |
| IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| IPR014715 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2 |
| IPR003961 | Fibronectin type III |
| IPR013783 | Immunoglobulin-like fold |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=TN-R 180, 180 kDa form; IsoId=Q05546-1; Sequence=Displayed; Name=2; Synonyms=TN-R 160, 160 kDa form; IsoId=Q05546-2; Sequence=VSP_012995; |
| Developmental Stage | Expression in oligodendrocytes is highest between the second and third postnatal week and low in the adult. In contrast the expression in neurons increases from birth to third postnatal week and is continuous from late development to adulthood. Isoform 1 is the dominant form early in development. Isoform 2 is more prominent later in development and in adulthood |
| Domain | The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B. |
| Function | Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity) |
| Ptm | Contains N-linked oligosaccharides, O-linked sialylated structures (By similarity). Contains O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type GalNAc-4-SO4 or HNK-1 (SO4-3- GlcUABeta1,3GalBeta1,4GlcNAc). The levels of HNK-1 rise and fall in parallel to those of TNR during postnatal development of the cerebellum. In contrast, levels of GalNAc-4-SO4 are regulated independently from those of TNR, rising late in cerebellar development and continuing into adulthood. Early in postnatal development, GalNAc-4-SO4 is found predominantly on isoform 1, whereas in the adult it is predominantly on isoform 2. {ECO:0000250, ECO:0000269|PubMed:10723065, ECO:0000269|PubMed:12393878, ECO:0000269|PubMed:14681222}. |
| Similarity | Belongs to the tenascin family |
| Similarity | Contains 1 fibrinogen C-terminal domain |
| Similarity | Contains 5 EGF-like domains |
| Similarity | Contains 9 fibronectin type-III domains |
| Subcellular Location | Secreted, extracellular space, extracellular matrix. |
| Subunit | Forms oligomers. Interacts with TNC and FN1 (By similarity). Interacts with BCAN and ACAN in a calcium -dependent manner. Interacts with CNTN1, SCN2B, PTPRZ1, and CSPG3. {ECO:0000250, ECO:0000269|PubMed:15296743, ECO:0000269|PubMed:9081628, ECO:0000269|PubMed:9294172, ECO:0000269|PubMed:9507007, ECO:0000269|PubMed:9861042}. |
| Tissue Specificity | Brain-specific. Expressed in oligodendrocytes and small subsets of neurons (mainly interneurons and motoneurons) of the cerebellum, hippocampus and olfactory bulb |
Identical and Related Proteins
Unique RefSeq proteins for LMP012527 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6981668 | RefSeq | NP_037177 | 1356 | tenascin-R precursor |
Identical Sequences to LMP012527 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981668 | EMBL | CAA79229.1 | 1356 | neural recognition molecule J1-160/180 [Rattus norvegicus] |
| GI:6981668 | SwissProt | Q05546.1 | 1356 | RecName: Full=Tenascin-R; Short=TN-R; AltName: Full=Janusin; AltName: Full=Neural recognition molecule J1-160/180; AltName: Full=Restrictin; Flags: Precursor [Rattus norvegicus] |
Related Sequences to LMP012527 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981668 | EMBL | CAA79229.1 | 1356 | neural recognition molecule J1-160/180 [Rattus norvegicus] |
| GI:6981668 | GenBank | EDM09448.1 | 1358 | tenascin R, isoform CRA_b [Rattus norvegicus] |
| GI:6981668 | SwissProt | Q05546.1 | 1356 | RecName: Full=Tenascin-R; Short=TN-R; AltName: Full=Janusin; AltName: Full=Neural recognition molecule J1-160/180; AltName: Full=Restrictin; Flags: Precursor [Rattus norvegicus] |