Gene/Proteome Database (LMPD)

LMPD ID
LMP012536
Gene ID
25618
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA dehydrogenase, short/branched chain
Gene Symbol
Acadsb
Alternate Names
short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-MEBCAD; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methyl branched chain acyl-CoA dehydrogenase; Acyl-Coenzyme A dehydrogenase short-branched chain; acyl-Coenzyme A dehydrogenase, short/branched chain;
Chromosome
1
Map Location
1q41
EC Number
1.3.8.5
Summary
catalyzes the alpha, beta-dehydrogenation of valproyl-CoA and other acyl-CoA esters in fatty acid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acadsb

Proteins

short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Refseq ID NP_037216
Protein GI 6978433
UniProt ID P70584
mRNA ID NM_013084
Length 432
MAVSAFQLWRAGGLLRRNFLTHSSSWKIPPRVLKSSQPEALLSVTNNALCFAPLQTFTDEDIMMQKAVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGMMGIEVEAKYGGTEASFLCSVLVIEELAKVDASVALLCDIQNTVINKLFRKHGTEEQKATYLPKLVTEKLGSFCLSEAGAGSDSFALKTRADKSGNYYVINGSKMWISNAEHAELFLVFANVDPPSGYRGITCFLVDRDTEGFQIGRRENKMGIRASSTCQLTFENVKVPETSVLGKIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERMQFGKRIFDFQGLQHQVAHVATQLEAARLLTYNAARLVEAGRPFIKEASMAKYYASEVAGLTTSKCIEWMGGVGYTKDYPVEKFFRDAKIGTIYEGTSNIQLNTIAKHIDAEY
transit_peptide: 1..33 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P70584.1) calculated_mol_wt: 3797 peptide sequence: MAVSAFQLWRAGGLLRRNFLTHSSSWKIPPRVL mat_peptide: 34..432 product: short/branched chain specific acyl-CoA dehydrogenase, mitochondrial calculated_mol_wt: 44046 peptide sequence: KSSQPEALLSVTNNALCFAPLQTFTDEDIMMQKAVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGMMGIEVEAKYGGTEASFLCSVLVIEELAKVDASVALLCDIQNTVINKLFRKHGTEEQKATYLPKLVTEKLGSFCLSEAGAGSDSFALKTRADKSGNYYVINGSKMWISNAEHAELFLVFANVDPPSGYRGITCFLVDRDTEGFQIGRRENKMGIRASSTCQLTFENVKVPETSVLGKIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERMQFGKRIFDFQGLQHQVAHVATQLEAARLLTYNAARLVEAGRPFIKEASMAKYYASEVAGLTTSKCIEWMGGVGYTKDYPVEKFFRDAKIGTIYEGTSNIQLNTIAKHIDAEY

Gene Information

Entrez Gene ID
25618
Gene Name
acyl-CoA dehydrogenase, short/branched chain
Gene Symbol
Acadsb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 TAS:RGD C mitochondrion
GO:0003995 IDA:RGD F acyl-CoA dehydrogenase activity
GO:0009055 IDA:RGD F electron carrier activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0016937 IDA:MGI F short-branched-chain-acyl-CoA dehydrogenase activity
GO:0006637 IDA:MGI P acyl-CoA metabolic process
GO:0006635 TAS:RGD P fatty acid beta-oxidation
GO:0006631 TAS:RGD P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
ILEUDEG-PWY isoleucine degradation I
VALDEG-PWY valine degradation I

REACTOME Pathway Links

REACTOME Pathway ID Description
5953282 Branched-chain amino acid catabolism
5953250 Metabolism
5953272 Metabolism of amino acids and derivatives

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-CoA dehydrogenase, short/branched chain
Protein Entry
ACDSB_RAT
UniProt ID
P70584
Species
Rat

Comments

Comment Type Description
Catalytic Activity 2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron- transfer flavoprotein + H(+)
Catalytic Activity Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
Function Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent
Pathway Lipid metabolism; mitochondrial fatty acid beta- oxidation.
Similarity Belongs to the acyl-CoA dehydrogenase family
Subcellular Location Mitochondrion matrix .
Subunit Homotetramer
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP012536 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978433 RefSeq NP_037216 432 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Identical Sequences to LMP012536 proteins

Reference Database Accession Length Protein Name
GI:6978433 GenBank AAB17136.1 432 short-branched chain acyl-CoA dehydrogenase precursor [Rattus norvegicus]
GI:6978433 GenBank EDM11701.1 432 acyl-Coenzyme A dehydrogenase, short/branched chain, isoform CRA_b [Rattus norvegicus]
GI:6978433 SwissProt P70584.1 432 RecName: Full=Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Short=SBCAD; AltName: Full=2-methyl branched chain acyl-CoA dehydrogenase; Short=2-MEBCAD; AltName: Full=2-methylbutyryl-coenzyme A dehydrogenase; Short=2-methylbutyryl-CoA dehydrogenase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012536 proteins

Reference Database Accession Length Protein Name
GI:6978433 GenBank AAB17136.1 432 short-branched chain acyl-CoA dehydrogenase precursor [Rattus norvegicus]
GI:6978433 GenBank EDM11701.1 432 acyl-Coenzyme A dehydrogenase, short/branched chain, isoform CRA_b [Rattus norvegicus]
GI:6978433 SwissProt P70584.1 432 RecName: Full=Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Short=SBCAD; AltName: Full=2-methyl branched chain acyl-CoA dehydrogenase; Short=2-MEBCAD; AltName: Full=2-methylbutyryl-coenzyme A dehydrogenase; Short=2-methylbutyryl-CoA dehydrogenase; Flags: Precursor [Rattus norvegicus]