Gene/Proteome Database (LMPD)
LMPD ID
LMP012538
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin E receptor 1 (subtype EP1)
Gene Symbol
Synonyms
EP1;
Alternate Names
prostaglandin E2 receptor EP1 subtype; EP1 prostanoid receptor; prostanoid EP1 receptor; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor EP1 subtype;
Chromosome
19
Map Location
19q11
Summary
binds prostaglandin E2; plays a role in G-protein coupled receptor signaling and Ca2+ mobilization [RGD, Feb 2006]
Orthologs
Proteins
| prostaglandin E2 receptor EP1 subtype | |
|---|---|
| Refseq ID | NP_001265404 |
| Protein GI | 511093983 |
| UniProt ID | P70597 |
| mRNA ID | NM_001278475 |
| Length | 405 |
| MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL | |
Gene Information
Entrez Gene ID
Gene Name
prostaglandin E receptor 1 (subtype EP1)
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0004957 | IDA:RGD | F | prostaglandin E receptor activity |
| GO:0032496 | IEA:Ensembl | P | response to lipopolysaccharide |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04020 | Calcium signaling pathway |
| rno04020 | Calcium signaling pathway |
| ko04080 | Neuroactive ligand-receptor interaction |
| rno04080 | Neuroactive ligand-receptor interaction |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954122 | Class A/1 (Rhodopsin-like receptors) |
| 5954202 | Eicosanoid ligand-binding receptors |
| 5953653 | G alpha (q) signalling events |
| 5953642 | GPCR downstream signaling |
| 5953758 | GPCR ligand binding |
| 5953537 | Gastrin-CREB signalling pathway via PKC and MAPK |
| 5954201 | Prostanoid ligand receptors |
| 5953381 | Signal Transduction |
| 5953391 | Signaling by GPCR |
Domain Information
UniProt Annotations
Entry Information
Gene Name
prostaglandin E receptor 1 (subtype EP1)
Protein Entry
PE2R1_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70597-1; Sequence=Displayed; Name=2; IsoId=P70597-2; Sequence=VSP_001927, VSP_001928; |
| Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues |
| Ptm | Phosphorylated |
| Similarity | Belongs to the G-protein coupled receptor 1 family |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly abundant in kidney and lung. Found in a lesser extent in spleen, colon, and thymus. Also expressed in uterine myometrium and endometrium. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012538 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 511093983 | RefSeq | NP_001265404 | 405 | prostaglandin E2 receptor EP1 subtype |
Identical Sequences to LMP012538 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:511093983 | DBBJ | BAA13691.1 | 405 | prostaglandin E receptor EP1 subtype [Rattus norvegicus] |
| GI:511093983 | GenBank | AAB07735.1 | 405 | EP1 prostanoid receptor [Rattus norvegicus] |
| GI:511093983 | SwissProt | P70597.1 | 405 | RecName: Full=Prostaglandin E2 receptor EP1 subtype; Short=PGE receptor EP1 subtype; Short=PGE2 receptor EP1 subtype; AltName: Full=Prostanoid EP1 receptor [Rattus norvegicus] |
Related Sequences to LMP012538 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:511093983 | DBBJ | BAA13691.1 | 405 | prostaglandin E receptor EP1 subtype [Rattus norvegicus] |
| GI:511093983 | GenBank | AAB07735.1 | 405 | EP1 prostanoid receptor [Rattus norvegicus] |
| GI:511093983 | SwissProt | P70597.1 | 405 | RecName: Full=Prostaglandin E2 receptor EP1 subtype; Short=PGE receptor EP1 subtype; Short=PGE2 receptor EP1 subtype; AltName: Full=Prostanoid EP1 receptor [Rattus norvegicus] |