Gene/Proteome Database (LMPD)
LMPD ID
LMP012542
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase, gamma
Gene Symbol
Synonyms
Dagk3; DGKIII;
Alternate Names
diacylglycerol kinase gamma; DGK-gamma; DAG kinase gamma; diglyceride kinase gamma; 88 kDa diacylglycerol kinase; Diacylglycerol kinase 3 (gamma);
Chromosome
11
Map Location
11q23
EC Number
2.7.1.107
Summary
putative diacylglycerol kinase associated with the cytoskeleton of purkinje cells [RGD, Feb 2006]
Orthologs
Proteins
diacylglycerol kinase gamma | |
---|---|
Refseq ID | NP_037258 |
Protein GI | 6978761 |
UniProt ID | P49620 |
mRNA ID | NM_013126 |
Length | 788 |
MSDGQWVCLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLKQYDPHKPISYDVFKLFMRAYLEVDLPQPLSTNLFLAFSQKPRQETPDHPKEGASSSEPNVSDSNAESTAKADAACAPDTESKPIKTQVPSEELEAAAPWGEPNAPASSSDAPIVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENELLDQAELDQIVSQMLHVAQYLEWDPTELRPILKEMLQGMDYNKDGFVSLEEWVSGGMTTIPLLVLLGMDDSASKGDGRHAWTLKHFKKPTYCNFCHIMLMGVRKQGLCCIYCKYAVHQRCVSNSIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTACDGGELKDHILLPTSIYPVTRDRQAGKSDSGAAAKGELVMQYKIIPSPGTHPLLVLVNPKSGGRQGERILQKFHYLLNPKQVFNLDKGGPTPGLNFFQDTPDFRVLACGGDGTVGWILDCIDKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEVENGDQVPYNIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTKKLLPMQVDGEPWMQPPCMIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD |
Gene Information
Entrez Gene ID
Gene Name
diacylglycerol kinase, gamma
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0043231 | IEA:Ensembl | C | intracellular membrane-bounded organelle |
GO:0005886 | IEA:Ensembl | C | plasma membrane |
GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
GO:0003951 | IEA:InterPro | F | NAD+ kinase activity |
GO:0005509 | IEA:InterPro | F | calcium ion binding |
GO:0004143 | IDA:RGD | F | diacylglycerol kinase activity |
GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
GO:0048666 | IEP:RGD | P | neuron development |
GO:0007205 | TAS:RGD | P | protein kinase C-activating G-protein coupled receptor signaling pathway |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
ko00561 | Glycerolipid metabolism |
rno00561 | Glycerolipid metabolism |
ko00564 | Glycerophospholipid metabolism |
rno00564 | Glycerophospholipid metabolism |
rno01100 | Metabolic pathways |
ko04070 | Phosphatidylinositol signaling system |
rno04070 | Phosphatidylinositol signaling system |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
5953655 | Effects of PIP2 hydrolysis |
5953653 | G alpha (q) signalling events |
5953642 | GPCR downstream signaling |
5953537 | Gastrin-CREB signalling pathway via PKC and MAPK |
5953645 | Hemostasis |
5953644 | Platelet activation, signaling and aggregation |
5953381 | Signal Transduction |
5953391 | Signaling by GPCR |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR016064 | ATP-NAD kinase-like domain |
IPR029477 | Diacylglycerol kinase type I, N-terminal |
IPR000756 | Diacylglycerol kinase, accessory domain |
IPR001206 | Diacylglycerol kinase, catalytic domain |
IPR018247 | EF-Hand 1, calcium-binding site |
IPR002048 | EF-hand domain |
IPR011992 | EF-hand domain pair |
IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Catalytic Activity | ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate. |
Similarity | Belongs to the eukaryotic diacylglycerol kinase family |
Similarity | Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}. |
Similarity | Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
Similarity | Contains 2 phorbol-ester/DAG-type zinc fingers |
Tissue Specificity | Expressed specifically in brain and localized predominantly in cerebellar Purkinje cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012542 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
6978761 | RefSeq | NP_037258 | 788 | diacylglycerol kinase gamma |
Identical Sequences to LMP012542 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:6978761 | DBBJ | BAA07480.1 | 788 | 88kDa-diacylglycerol kinase [Rattus norvegicus] |
GI:6978761 | PIR | - | 788 | diacylglycerol kinase (EC 2.7.1.107) gamma - rat [Rattus sp.] |
GI:6978761 | SwissProt | P49620.1 | 788 | RecName: Full=Diacylglycerol kinase gamma; Short=DAG kinase gamma; AltName: Full=88 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase gamma; Short=DGK-gamma [Rattus norvegicus] |
Related Sequences to LMP012542 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:6978761 | DBBJ | BAA07480.1 | 788 | 88kDa-diacylglycerol kinase [Rattus norvegicus] |
GI:6978761 | PIR | - | 788 | diacylglycerol kinase (EC 2.7.1.107) gamma - rat [Rattus sp.] |
GI:6978761 | SwissProt | P49620.1 | 788 | RecName: Full=Diacylglycerol kinase gamma; Short=DAG kinase gamma; AltName: Full=88 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase gamma; Short=DGK-gamma [Rattus norvegicus] |