Gene/Proteome Database (LMPD)

LMPD ID
LMP012549
Gene ID
25702
Species
Rattus norvegicus (Rat)
Gene Name
pancreatic lipase
Gene Symbol
Pnlip
Synonyms
PANLI;
Alternate Names
pancreatic triacylglycerol lipase; PL; pancreatic triglyceride lipase;
Chromosome
1
Map Location
1q55
EC Number
3.1.1.3

Proteins

pancreatic triacylglycerol lipase precursor
Refseq ID NP_037293
Protein GI 6981376
UniProt ID P27657
mRNA ID NM_013161
Length 465
MLMLWTFAVLLGAVAGKEVCFDKLGCFSDDAPWSGTIDRPLKALPWSPAQINTRFLLYTNENQDNYQKITSDASSIRNSNFKTNRKTRIIIHGFIDKGEENWLSDMCKNMFKVESVNCICVDWKGGSRATYTQATQNVRVVGAEVALLVNVLKSDLGHPPDNVHLIGHSLGSHVAGEAGKRTFGAIGRITGLDAAEPYFQGTPEEVRLDPTDAQFVDAIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGMEMPGCQKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPTGFSGFSCSSYNVFSANKCFPCGSEGCPQMGHYADKYPGKTKELYQKFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGNGGNSKQYEVFKGSLHPGDTHVKEFDSDMDVGDLQKVKFIWYNNVINPTLPKVGASRISVERNDGRVFNFCSQDTVREDVLLTLSAC
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1693 peptide sequence: MLMLWTFAVLLGAVAG mat_peptide: 17..465 product: pancreatic triacylglycerol lipase calculated_mol_wt: 49765 peptide sequence: KEVCFDKLGCFSDDAPWSGTIDRPLKALPWSPAQINTRFLLYTNENQDNYQKITSDASSIRNSNFKTNRKTRIIIHGFIDKGEENWLSDMCKNMFKVESVNCICVDWKGGSRATYTQATQNVRVVGAEVALLVNVLKSDLGHPPDNVHLIGHSLGSHVAGEAGKRTFGAIGRITGLDAAEPYFQGTPEEVRLDPTDAQFVDAIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGMEMPGCQKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPTGFSGFSCSSYNVFSANKCFPCGSEGCPQMGHYADKYPGKTKELYQKFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGNGGNSKQYEVFKGSLHPGDTHVKEFDSDMDVGDLQKVKFIWYNNVINPTLPKVGASRISVERNDGRVFNFCSQDTVREDVLLTLSAC

Gene Information

Entrez Gene ID
25702
Gene Name
pancreatic lipase
Gene Symbol
Pnlip
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0016298 IDA:RGD F lipase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004806 IDA:RGD F triglyceride lipase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006629 IDA:RGD P lipid metabolic process
GO:0009791 IDA:RGD P post-embryonic development
GO:0033993 IEP:RGD P response to lipid
GO:0043434 IEP:RGD P response to peptide hormone

KEGG Pathway Links

KEGG Pathway ID Description
M00098 Acylglycerol degradation
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
rno01100 Metabolic pathways
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
ko04977 Vitamin digestion and absorption
rno04977 Vitamin digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID Description
5953935 Digestion of dietary lipid
5953253 Disease
5953382 Diseases associated with visual transduction
5953754 Lipid digestion, mobilization, and transport
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954392 Retinoid metabolism and transport
5953381 Signal Transduction
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR002331 Pancreatic lipase
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
pancreatic lipase
Protein Entry
LIPP_RAT
UniProt ID
P27657
Species
Rat

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
Function Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
Induction By colipase/CLPS in the presence of bile salts.
Similarity Belongs to the AB hydrolase superfamily. Lipase family
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Secreted.
Tissue Specificity Pancreatic secretory (zymogen) granule.

Identical and Related Proteins

Unique RefSeq proteins for LMP012549 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981376 RefSeq NP_037293 465 pancreatic triacylglycerol lipase precursor

Identical Sequences to LMP012549 proteins

Reference Database Accession Length Protein Name
GI:6981376 GenBank AAA79888.1 465 pancreatic triglyceride lipase [Rattus norvegicus]
GI:6981376 GenBank ADS21269.1 465 Sequence 12 from patent US 7771960
GI:6981376 GenBank AFG81082.1 465 Sequence 12 from patent US 8138316
GI:6981376 PRF - 465 lipase [Rattus norvegicus]

Related Sequences to LMP012549 proteins

Reference Database Accession Length Protein Name
GI:6981376 GenBank AAA79888.1 465 pancreatic triglyceride lipase [Rattus norvegicus]
GI:6981376 GenBank AFG81082.1 465 Sequence 12 from patent US 8138316
GI:6981376 PRF - 465 lipase [Rattus norvegicus]