Gene/Proteome Database (LMPD)

LMPD ID
LMP012553
Gene ID
25728
Species
Rattus norvegicus (Rat)
Gene Name
apolipoprotein E
Gene Symbol
Apoe
Synonyms
APOEA;
Alternate Names
apolipoprotein E; apo-E;
Chromosome
1
Map Location
1q21
Summary
plays a role in plasma lipoprotein transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Apoe

Proteins

apolipoprotein E precursor
Refseq ID NP_620183
Protein GI 162287337
UniProt ID P02650
mRNA ID NM_138828
Length 312
MKALWALLLVPLLTGCLAEGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ
apolipoprotein E precursor
Refseq ID NP_001257613
Protein GI 397529602
UniProt ID P02650
mRNA ID NM_001270684
Length 312
Protein sequence is identical to GI:162287337 (mRNA isoform)
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ
apolipoprotein E precursor
Refseq ID NP_001257612
Protein GI 397529600
UniProt ID P02650
mRNA ID NM_001270683
Length 312
Protein sequence is identical to GI:162287337 (mRNA isoform)
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ
apolipoprotein E precursor
Refseq ID NP_001257611
Protein GI 397529598
UniProt ID P02650
mRNA ID NM_001270682
Length 312
Protein sequence is identical to GI:162287337 (mRNA isoform)
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ
apolipoprotein E precursor
Refseq ID NP_001257610
Protein GI 397529595
UniProt ID P02650
mRNA ID NM_001270681
Length 312
Protein sequence is identical to GI:162287337 (mRNA isoform)
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1927 peptide sequence: MKALWALLLVPLLTGCLA mat_peptide: 19..312 product: Apolipoprotein E experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02650.2) calculated_mol_wt: 33845 peptide sequence: EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ

Gene Information

Entrez Gene ID
25728
Gene Name
apolipoprotein E
Gene Symbol
Apoe
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0072562 IEA:Ensembl C blood microparticle
GO:0009986 IDA:RGD C cell surface
GO:0042627 IEA:UniProtKB-KW C chylomicron
GO:0005737 IDA:RGD C cytoplasm
GO:0030425 IDA:RGD C dendrite
GO:0034365 IDA:RGD C discoidal high-density lipoprotein particle
GO:0005783 IDA:RGD C endoplasmic reticulum
GO:0005768 IDA:RGD C endosome
GO:0005615 IDA:RGD C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0031232 IDA:RGD C extrinsic component of external side of plasma membrane
GO:0005794 IDA:RGD C Golgi apparatus
GO:0034363 IEA:Ensembl C intermediate-density lipoprotein particle
GO:0005770 IDA:RGD C late endosome
GO:0005764 IDA:RGD C lysosome
GO:0043025 IDA:RGD C neuronal cell body
GO:0005635 IDA:RGD C nuclear envelope
GO:0005886 IDA:RGD C plasma membrane
GO:0034361 IEA:UniProtKB-KW C very-low-density lipoprotein particle
GO:0016209 IEA:Ensembl F antioxidant activity
GO:0001540 ISS:UniProtKB F beta-amyloid binding
GO:0017127 IEA:Ensembl F cholesterol transporter activity
GO:0008201 IEA:UniProtKB-KW F heparin binding
GO:0046848 IDA:RGD F hydroxyapatite binding
GO:0005319 IDA:RGD F lipid transporter activity
GO:0071813 IEA:Ensembl F lipoprotein particle binding
GO:0046911 IEA:Ensembl F metal chelating activity
GO:0005543 IDA:RGD F phospholipid binding
GO:0005102 IPI:UniProt F receptor binding
GO:0007568 IDA:RGD P aging
GO:0097113 IEA:Ensembl P alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0048844 IEA:Ensembl P artery morphogenesis
GO:0006874 IEA:Ensembl P cellular calcium ion homeostasis
GO:0071397 IEP:RGD P cellular response to cholesterol
GO:0071363 IEP:RGD P cellular response to growth factor stimulus
GO:0071347 IEP:RGD P cellular response to interleukin-1
GO:0019934 IEA:Ensembl P cGMP-mediated signaling
GO:0006707 IEA:Ensembl P cholesterol catabolic process
GO:0033344 IEA:Ensembl P cholesterol efflux
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0034382 IEA:Ensembl P chylomicron remnant clearance
GO:0055089 IEA:Ensembl P fatty acid homeostasis
GO:0007186 IEA:Ensembl P G-protein coupled receptor signaling pathway
GO:0034380 IEA:Ensembl P high-density lipoprotein particle assembly
GO:0034384 IEA:Ensembl P high-density lipoprotein particle clearance
GO:0034375 IEA:Ensembl P high-density lipoprotein particle remodeling
GO:0006869 IDA:RGD P lipid transport
GO:0042158 IEA:Ensembl P lipoprotein biosynthetic process
GO:0042159 IEA:Ensembl P lipoprotein catabolic process
GO:0042157 IDA:RGD P lipoprotein metabolic process
GO:0015909 IEA:Ensembl P long-chain fatty acid transport
GO:0034374 IEA:Ensembl P low-density lipoprotein particle remodeling
GO:0051651 IEA:Ensembl P maintenance of location in cell
GO:1902430 IEA:Ensembl P negative regulation of beta-amyloid formation
GO:0043537 IEA:Ensembl P negative regulation of blood vessel endothelial cell migration
GO:0045541 IEA:Ensembl P negative regulation of cholesterol biosynthetic process
GO:0090370 IEA:Ensembl P negative regulation of cholesterol efflux
GO:0061000 IEA:Ensembl P negative regulation of dendritic spine development
GO:1902951 IEA:Ensembl P negative regulation of dendritic spine maintenance
GO:0001937 IEA:Ensembl P negative regulation of endothelial cell proliferation
GO:0050728 IEA:Ensembl P negative regulation of inflammatory response
GO:1903001 IEA:Ensembl P negative regulation of lipid transport across blood brain barrier
GO:0043407 IEA:Ensembl P negative regulation of MAP kinase activity
GO:0043524 IDA:RGD P negative regulation of neuron apoptotic process
GO:1902999 IEA:Ensembl P negative regulation of phospholipid efflux
GO:0010544 IEA:Ensembl P negative regulation of platelet activation
GO:1901627 IEA:Ensembl P negative regulation of postsynaptic membrane organization
GO:1901630 IEA:Ensembl P negative regulation of presynaptic membrane organization
GO:0031102 TAS:RGD P neuron projection regeneration
GO:0007263 IEA:Ensembl P nitric oxide mediated signal transduction
GO:0097114 IEA:Ensembl P N-methyl-D-aspartate receptor clustering
GO:0048709 IEP:RGD P oligodendrocyte differentiation
GO:0014012 IEP:RGD P peripheral nervous system axon regeneration
GO:0033700 IEA:Ensembl P phospholipid efflux
GO:0045773 IDA:RGD P positive regulation of axon extension
GO:1902004 IEA:Ensembl P positive regulation of beta-amyloid formation
GO:0030828 IEA:Ensembl P positive regulation of cGMP biosynthetic process
GO:0010875 IEA:Ensembl P positive regulation of cholesterol efflux
GO:0060999 IEA:Ensembl P positive regulation of dendritic spine development
GO:1902952 IEA:Ensembl P positive regulation of dendritic spine maintenance
GO:0046889 IEA:Ensembl P positive regulation of lipid biosynthetic process
GO:1903002 IEA:Ensembl P positive regulation of lipid transport across blood brain barrier
GO:0032805 IEA:Ensembl P positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0051044 IEA:Ensembl P positive regulation of membrane protein ectodomain proteolysis
GO:1902998 IEA:Ensembl P positive regulation of neurofibrillary tangle assembly
GO:1901216 IEA:Ensembl P positive regulation of neuron death
GO:0051000 IEA:Ensembl P positive regulation of nitric-oxide synthase activity
GO:1902995 IEA:Ensembl P positive regulation of phospholipid efflux
GO:1901628 IEA:Ensembl P positive regulation of postsynaptic membrane organization
GO:1901631 IEA:Ensembl P positive regulation of presynaptic membrane organization
GO:0017038 IEA:Ensembl P protein import
GO:0006898 IEA:Ensembl P receptor-mediated endocytosis
GO:1900221 IEA:Ensembl P regulation of beta-amyloid clearance
GO:0032489 IEA:Ensembl P regulation of Cdc42 protein signal transduction
GO:1902947 IEA:Ensembl P regulation of tau-protein kinase activity
GO:0002021 IEA:Ensembl P response to dietary excess
GO:0045471 IEP:RGD P response to ethanol
GO:0032868 IEP:RGD P response to insulin
GO:0006979 IEA:Ensembl P response to oxidative stress
GO:0032526 IEP:RGD P response to retinoic acid
GO:0043691 IEA:Ensembl P reverse cholesterol transport
GO:0006641 IEA:Ensembl P triglyceride metabolic process
GO:0042311 IEA:Ensembl P vasodilation
GO:0034447 IEA:Ensembl P very-low-density lipoprotein particle clearance

KEGG Pathway Links

KEGG Pathway ID Description
ko05010 Alzheimer's disease
rno05010 Alzheimer's disease

REACTOME Pathway Links

REACTOME Pathway ID Description
5954562 Binding and Uptake of Ligands by Scavenger Receptors
5953879 Chylomicron-mediated lipid transport
5953253 Disease
5953382 Diseases associated with visual transduction
5954088 HDL-mediated lipid transport
5953754 Lipid digestion, mobilization, and transport
5953836 Lipoprotein metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954392 Retinoid metabolism and transport
5954564 Scavenging by Class A Receptors
5953381 Signal Transduction
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein E
Protein Entry
APOE_RAT
UniProt ID
P02650
Species
Rat

Comments

Comment Type Description
Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Miscellaneous The mature protein has no cysteine residues; however, in different allelic variants where cysteine residues replace arginine at positions 155 or 168, binding of Apo-E to cell membrane receptors is decreased. The amino end of this protein is therefore thought to interact with the receptor.
Ptm Phosphorylation sites are present in the extracellular medium
Similarity Belongs to the apolipoprotein A1/A4/E family
Subcellular Location Secreted.
Tissue Specificity Secreted in plasma.

Identical and Related Proteins

Unique RefSeq proteins for LMP012553 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
162287337 RefSeq NP_620183 312 apolipoprotein E precursor

Identical Sequences to LMP012553 proteins

Reference Database Accession Length Protein Name
GI:397529598 GenBank AHH58260.1 312 Sequence 5 from patent US 8617877
GI:397529602 GenBank AHH58260.1 312 Sequence 5 from patent US 8617877
GI:397529600 GenBank AHH58260.1 312 Sequence 5 from patent US 8617877
GI:397529595 GenBank AHH58260.1 312 Sequence 5 from patent US 8617877
GI:162287337 GenBank AHH58260.1 312 Sequence 5 from patent US 8617877
GI:397529602 GenBank AHH58303.1 312 Sequence 48 from patent US 8617877
GI:162287337 GenBank AHH58303.1 312 Sequence 48 from patent US 8617877
GI:397529595 GenBank AHH58303.1 312 Sequence 48 from patent US 8617877
GI:397529598 GenBank AHH58303.1 312 Sequence 48 from patent US 8617877
GI:397529600 GenBank AHH58303.1 312 Sequence 48 from patent US 8617877
GI:397529602 RefSeq NP_001257611.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:397529600 RefSeq NP_001257611.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:397529595 RefSeq NP_001257612.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:162287337 RefSeq NP_001257612.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:397529602 RefSeq NP_001257612.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:397529598 RefSeq NP_001257612.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:162287337 RefSeq NP_001257613.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:397529595 RefSeq NP_001257613.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:397529598 RefSeq NP_001257613.1 312 apolipoprotein E precursor [Rattus norvegicus]
GI:397529600 RefSeq NP_001257613.1 312 apolipoprotein E precursor [Rattus norvegicus]

Related Sequences to LMP012553 proteins

Reference Database Accession Length Protein Name
GI:397529595 GenBank AAH86581.1 312 Apolipoprotein E [Rattus norvegicus]
GI:397529602 GenBank AAH86581.1 312 Apolipoprotein E [Rattus norvegicus]
GI:397529598 GenBank AAH86581.1 312 Apolipoprotein E [Rattus norvegicus]
GI:397529600 GenBank AAH86581.1 312 Apolipoprotein E [Rattus norvegicus]
GI:162287337 GenBank EDM08159.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529598 GenBank EDM08159.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529600 GenBank EDM08159.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529595 GenBank EDM08159.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529602 GenBank EDM08159.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529598 GenBank EDM08163.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:162287337 GenBank EDM08163.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529595 GenBank EDM08163.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529600 GenBank EDM08163.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529602 GenBank EDM08163.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529600 GenBank EDM08169.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529595 GenBank EDM08169.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:162287337 GenBank EDM08169.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529598 GenBank EDM08169.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]
GI:397529602 GenBank EDM08169.1 312 apolipoprotein E, isoform CRA_a [Rattus norvegicus]