Gene/Proteome Database (LMPD)

LMPD ID
LMP012554
Gene ID
25732
Species
Rattus norvegicus (Rat)
Gene Name
acid phosphatase 5, tartrate resistant
Gene Symbol
Acp5
Synonyms
Trap; TTRRAP;
Alternate Names
tartrate-resistant acid phosphatase type 5; TR-AP; trATPase; acid phosphatase type V; type 5 acid phosphatase; tartrate-resistant acid ATPase;
Chromosome
8
Map Location
chromosome:8
EC Number
3.1.3.2
Summary
tartrate-resistant acid phosphatase; may be involved in bone resorption; 5b isoform is osteoclast-specific and may be a specific marker of bone resorption [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acp5

Proteins

tartrate-resistant acid phosphatase type 5 isoform 1 precursor
Refseq ID NP_062017
Protein GI 399788505
UniProt ID P29288
mRNA ID NM_019144
Length 335
MTTCASSSMDTWMVLLGLQILLLPLLAHCTAPASTLRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQIMGADFIMSLGDNFYFTGVHDANDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKVPRSNITVAIFMLDTVMLCGNSDDFVSQQPEMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLAAYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTYVEIGSKEMSITYVEASGKSLFKTSLPRRPRP
sig_peptide: 1..22 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P29288.1) calculated_mol_wt: 2495 peptide sequence: MDTWMVLLGLQILLLPLLAHCT mat_peptide: 23..327 product: Tartrate-resistant acid phosphatase type 5 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P29288.1) calculated_mol_wt: 34249 peptide sequence: APASTLRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQIMGADFIMSLGDNFYFTGVHDANDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKVPRSNITVAIFMLDTVMLCGNSDDFVSQQPEMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLAAYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTYVEIGSKEMSITYVEASGKSLFKTSLPRRPRP sig_peptide: 1..27 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2923 peptide sequence: MTTCASSSMDTWMVLLGLQILLLPLLA
tartrate-resistant acid phosphatase type 5 isoform 2 precursor
Refseq ID NP_001257818
Protein GI 400153701
UniProt ID P29288
mRNA ID NM_001270889
Length 327
MDTWMVLLGLQILLLPLLAHCTAPASTLRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQIMGADFIMSLGDNFYFTGVHDANDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKVPRSNITVAIFMLDTVMLCGNSDDFVSQQPEMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLAAYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTYVEIGSKEMSITYVEASGKSLFKTSLPRRPRP
sig_peptide: 1..22 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P29288.1) calculated_mol_wt: 2495 peptide sequence: MDTWMVLLGLQILLLPLLAHCT mat_peptide: 23..327 product: Tartrate-resistant acid phosphatase type 5 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P29288.1) calculated_mol_wt: 34249 peptide sequence: APASTLRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQIMGADFIMSLGDNFYFTGVHDANDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKVPRSNITVAIFMLDTVMLCGNSDDFVSQQPEMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLAAYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTYVEIGSKEMSITYVEASGKSLFKTSLPRRPRP

Gene Information

Entrez Gene ID
25732
Gene Name
acid phosphatase 5, tartrate resistant
Gene Symbol
Acp5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0016021 TAS:RGD C integral component of membrane
GO:0005764 TAS:RGD C lysosome
GO:0003993 IDA:RGD F acid phosphatase activity
GO:0008199 ISS:UniProtKB F ferric iron binding
GO:0008198 ISS:UniProtKB F ferrous iron binding
GO:0016787 IDA:RGD F hydrolase activity
GO:0045453 IEP:RGD P bone resorption
GO:0016311 IDA:GOC P dephosphorylation
GO:0008152 IDA:GOC P metabolic process
GO:0033555 IEP:RGD P multicellular organismal response to stress
GO:0007162 IDA:RGD P negative regulation of cell adhesion
GO:0001503 IEP:RGD P ossification
GO:0030316 IEP:RGD P osteoclast differentiation
GO:0030335 IMP:RGD P positive regulation of cell migration
GO:0033591 IEP:RGD P response to L-ascorbic acid
GO:0070723 IEP:RGD P response to cholesterol
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0010043 IEP:RGD P response to zinc ion

KEGG Pathway Links

KEGG Pathway ID Description
ko04142 Lysosome
rno04142 Lysosome
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
ko05323 Rheumatoid arthritis
rno05323 Rheumatoid arthritis
ko00740 Riboflavin metabolism
rno00740 Riboflavin metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953298 Defective AMN causes hereditary megaloblastic anemia 1
5953308 Defective BTD causes biotidinase deficiency
5953307 Defective CD320 causes methylmalonic aciduria
5953299 Defective CUBN causes hereditary megaloblastic anemia 1
5953296 Defective GIF causes intrinsic factor deficiency
5953310 Defective HLCS causes multiple carboxylase deficiency
5953297 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
5953305 Defective MMAA causes methylmalonic aciduria type cblA
5953302 Defective MMAB causes methylmalonic aciduria type cblB
5953304 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
5953303 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
5953301 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
5953300 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
5953306 Defective MUT causes methylmalonic aciduria mut type
5953293 Defective TCN2 causes hereditary megaloblastic anemia
5953309 Defects in biotin (Btn) metabolism
5953294 Defects in cobalamin (B12) metabolism
5953295 Defects in vitamin and cofactor metabolism
5953253 Disease
5953250 Metabolism
5953292 Metabolism of vitamins and cofactors
5953291 Metabolism of water-soluble vitamins and cofactors
5953987 Vitamin B2 (riboflavin) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR024927 Acid_Pase_5
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like

UniProt Annotations

Entry Information

Gene Name
acid phosphatase 5, tartrate resistant
Protein Entry
PPA5_RAT
UniProt ID
P29288
Species
Rat

Comments

Comment Type Description
Catalytic Activity A phosphate monoester + H(2)O = an alcohol + phosphate.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.;
Function May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.
Subcellular Location Lysosome.
Subunit Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).
Tissue Specificity Characteristic constituent of osteoclasts and some mononuclear preosteoclasts. Preferentially expressed in skeletal tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP012554 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
399788505 RefSeq NP_062017 335 tartrate-resistant acid phosphatase type 5 isoform 1 precursor
400153701 RefSeq NP_001257818 327 tartrate-resistant acid phosphatase type 5 isoform 2 precursor

Identical Sequences to LMP012554 proteins

Reference Database Accession Length Protein Name
GI:400153701 GenBank EDL78224.1 327 acid phosphatase 5, tartrate resistant, isoform CRA_a [Rattus norvegicus]
GI:399788505 GenBank EDL78225.1 335 acid phosphatase 5, tartrate resistant, isoform CRA_b [Rattus norvegicus]
GI:399788505 RefSeq XP_006242753.1 335 PREDICTED: tartrate-resistant acid phosphatase type 5 isoform X1 [Rattus norvegicus]
GI:400153701 RefSeq XP_006242754.1 327 PREDICTED: tartrate-resistant acid phosphatase type 5 isoform X2 [Rattus norvegicus]
GI:400153701 RefSeq XP_006242755.1 327 PREDICTED: tartrate-resistant acid phosphatase type 5 isoform X2 [Rattus norvegicus]
GI:400153701 RefSeq XP_006242756.1 327 PREDICTED: tartrate-resistant acid phosphatase type 5 isoform X2 [Rattus norvegicus]

Related Sequences to LMP012554 proteins

Reference Database Accession Length Protein Name
GI:399788505 GenBank AAH78847.1 327 Acp5 protein [Rattus norvegicus]
GI:400153701 GenBank AAH78847.1 327 Acp5 protein [Rattus norvegicus]
GI:400153701 GenBank EDL78224.1 327 acid phosphatase 5, tartrate resistant, isoform CRA_a [Rattus norvegicus]
GI:399788505 GenBank EDL78225.1 335 acid phosphatase 5, tartrate resistant, isoform CRA_b [Rattus norvegicus]
GI:399788505 RefSeq XP_006242753.1 335 PREDICTED: tartrate-resistant acid phosphatase type 5 isoform X1 [Rattus norvegicus]
GI:400153701 SwissProt P29288.1 327 RecName: Full=Tartrate-resistant acid phosphatase type 5; Short=TR-AP; AltName: Full=Tartrate-resistant acid ATPase; Short=TrATPase; AltName: Full=Type 5 acid phosphatase; Flags: Precursor [Rattus norvegicus]