Gene/Proteome Database (LMPD)
LMPD ID
LMP012555
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
hepatocyte nuclear factor 4, alpha
Gene Symbol
Synonyms
Hnf4; Hnf4alpha;
Alternate Names
hepatocyte nuclear factor 4-alpha; TCF-14; HNF-4-alpha; transcription factor 14; transcription factor HNF-4; alpha transcription factor 4; hepatic nuclear factor 4, alpha; nuclear receptor subfamily 2 group A member 1;
Chromosome
3
Map Location
3q42-q43
Summary
steriod horomone receptor; involved in promoting transcription [RGD, Feb 2006]
Orthologs
Proteins
hepatocyte nuclear factor 4-alpha isoform 1 | |
---|---|
Refseq ID | NP_071516 |
Protein GI | 400153986 |
UniProt ID | P22449 |
mRNA ID | NM_022180 |
Length | 474 |
MRLSKTLADMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKRIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI |
hepatocyte nuclear factor 4-alpha isoform 2 | |
---|---|
Refseq ID | NP_001257860 |
Protein GI | 400153996 |
UniProt ID | B9VVT3 |
mRNA ID | NM_001270931 |
Length | 449 |
MSDRGQGFLQDPPDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKRIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI |
hepatocyte nuclear factor 4-alpha isoform 3 | |
---|---|
Refseq ID | NP_001257862 |
Protein GI | 400154015 |
UniProt ID | B9VVT2 |
mRNA ID | NM_001270933 |
Length | 439 |
MSDRGQGFLQDPPDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKRIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMSTPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI |
Gene Information
Entrez Gene ID
Gene Name
hepatocyte nuclear factor 4, alpha
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005737 | IDA:RGD | C | cytoplasm |
GO:0005634 | IDA:BHF-UCL | C | nucleus |
GO:0005667 | IDA:RGD | C | transcription factor complex |
GO:0003677 | IDA:RGD | F | DNA binding |
GO:0001077 | IDA:BHF-UCL | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
GO:0005504 | IPI:RGD | F | fatty acid binding |
GO:0000062 | IPI:RGD | F | fatty-acyl-CoA binding |
GO:0004879 | IEA:InterPro | F | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
GO:0016290 | IDA:RGD | F | palmitoyl-CoA hydrolase activity |
GO:0042803 | IMP:RGD | F | protein homodimerization activity |
GO:0070491 | IPI:BHF-UCL | F | repressing transcription factor binding |
GO:0043565 | IMP:RGD | F | sequence-specific DNA binding |
GO:0003700 | IMP:RGD | F | sequence-specific DNA binding transcription factor activity |
GO:0003707 | TAS:RGD | F | steroid hormone receptor activity |
GO:0008134 | IPI:RGD | F | transcription factor binding |
GO:0008270 | IEA:InterPro | F | zinc ion binding |
GO:0006637 | IDA:RGD | P | acyl-CoA metabolic process |
GO:0030154 | IMP:RGD | P | cell differentiation |
GO:0045216 | IDA:RGD | P | cell-cell junction organization |
GO:0007164 | IDA:RGD | P | establishment of tissue polarity |
GO:0008285 | IDA:RGD | P | negative regulation of cell proliferation |
GO:0045930 | IDA:RGD | P | negative regulation of mitotic cell cycle |
GO:0050732 | IDA:RGD | P | negative regulation of peptidyl-tyrosine phosphorylation |
GO:0033159 | IDA:RGD | P | negative regulation of protein import into nucleus, translocation |
GO:0043433 | IDA:RGD | P | negative regulation of sequence-specific DNA binding transcription factor activity |
GO:0042524 | IDA:RGD | P | negative regulation of tyrosine phosphorylation of Stat5 protein |
GO:0045723 | IMP:RGD | P | positive regulation of fatty acid biosynthetic process |
GO:0045722 | IMP:RGD | P | positive regulation of gluconeogenesis |
GO:0045944 | IDA:BHF-UCL | P | positive regulation of transcription from RNA polymerase II promoter |
GO:0045893 | IDA:BHF-UCL | P | positive regulation of transcription, DNA-templated |
GO:0032534 | IMP:RGD | P | regulation of microvillus assembly |
GO:0006355 | IDA:RGD | P | regulation of transcription, DNA-templated |
GO:0051591 | IEP:RGD | P | response to cAMP |
GO:0042493 | IEP:RGD | P | response to drug |
GO:0009749 | IDA:RGD | P | response to glucose |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
ko04152 | AMPK signaling pathway |
rno04152 | AMPK signaling pathway |
ko04950 | Maturity onset diabetes of the young |
rno04950 | Maturity onset diabetes of the young |
REACTOME Pathway Links
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P22449-1; Sequence=Displayed; Name=Short; IsoId=P22449-2; Sequence=VSP_003677; |
Function | Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine. |
Interaction | P02692:Fabp1; NbExp=3; IntAct=EBI-5261592, EBI-1209448; |
Miscellaneous | Binds fatty acids. |
Miscellaneous | DNA-binding activity of phosphorylated protein is reduced by fasting and by inducers of intracellular cyclic AMP. |
Ptm | Acetylation at Lys-458 lowers transcriptional activation by about two-fold |
Ptm | Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity). Phosphorylated in the recognition sequence R-R-S-S near the DNA-binding domain; phosphorylation results in decrease in DNA-binding activity. Phosphorylation of HNF4 depends on the diet and is decreased by a carbohydrate-rich diet and is increased by fasting. {ECO:0000250, ECO:0000269|PubMed:9234678}. |
Ptm | The N-terminus is blocked. |
Sequence Caution | Sequence=BAA01411.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAA40412.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily |
Similarity | Contains 1 nuclear receptor DNA-binding domain |
Subcellular Location | Nucleus. |
Subunit | Homodimerization is required for HNF4-alpha to bind to its recognition site. Interacts with PER2. |
Tissue Specificity | Liver, kidney and intestine. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012555 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
400153986 | RefSeq | NP_071516 | 474 | hepatocyte nuclear factor 4-alpha isoform 1 |
400153996 | RefSeq | NP_001257860 | 449 | hepatocyte nuclear factor 4-alpha isoform 2 |
400154015 | RefSeq | NP_001257862 | 439 | hepatocyte nuclear factor 4-alpha isoform 3 |
Identical Sequences to LMP012555 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:400153986 | GenBank | EDL96572.1 | 474 | hepatocyte nuclear factor 4, alpha, isoform CRA_a [Rattus norvegicus] |
Related Sequences to LMP012555 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:400153986 | GenBank | AAX90602.1 | 474 | hepatic nuclear factor 4 alpha [Mus musculus] |
GI:400153986 | GenBank | EDL96572.1 | 474 | hepatocyte nuclear factor 4, alpha, isoform CRA_a [Rattus norvegicus] |
GI:400153996 | GenBank | EDL96573.1 | 452 | hepatocyte nuclear factor 4, alpha, isoform CRA_b [Rattus norvegicus] |
GI:400154015 | RefSeq | NP_001257860.1 | 449 | hepatocyte nuclear factor 4-alpha isoform 2 [Rattus norvegicus] |
GI:400153996 | RefSeq | XP_005363018.1 | 449 | PREDICTED: hepatocyte nuclear factor 4-alpha isoform X3 [Microtus ochrogaster] |
GI:400154015 | RefSeq | XP_005363019.1 | 439 | PREDICTED: hepatocyte nuclear factor 4-alpha isoform X4 [Microtus ochrogaster] |
GI:400153996 | RefSeq | XP_006971088.1 | 449 | PREDICTED: hepatocyte nuclear factor 4-alpha isoform X3 [Peromyscus maniculatus bairdii] |
GI:400154015 | RefSeq | XP_006971089.1 | 439 | PREDICTED: hepatocyte nuclear factor 4-alpha isoform X4 [Peromyscus maniculatus bairdii] |
GI:400153986 | SwissProt | P22449.3 | 474 | RecName: Full=Hepatocyte nuclear factor 4-alpha; Short=HNF-4-alpha; AltName: Full=Nuclear receptor subfamily 2 group A member 1; AltName: Full=Transcription factor 14; Short=TCF-14; AltName: Full=Transcription factor HNF-4 [Rattus norvegicus] |