Gene/Proteome Database (LMPD)

LMPD ID
LMP012557
Gene ID
25747
Species
Rattus norvegicus (Rat)
Gene Name
peroxisome proliferator activated receptor alpha
Gene Symbol
Ppara
Synonyms
PPAR;
Alternate Names
peroxisome proliferator-activated receptor alpha; PPAR-alpha; nuclear receptor subfamily 1 group C member 1;
Chromosome
7
Map Location
7q34
Summary
nuclear steroid receptor; heterodimerizes with retinoid-X receptor (RXR), and binds to peroxisome proliferator response elements (PPREs) to initiate the transcriptional regulation of target genes [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ppara

Proteins

peroxisome proliferator-activated receptor alpha
Refseq ID NP_037328
Protein GI 6981382
UniProt ID P37230
mRNA ID NM_013196
Length 468
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

Gene Information

Entrez Gene ID
25747
Gene Name
peroxisome proliferator activated receptor alpha
Gene Symbol
Ppara
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:RGD C nucleus
GO:0097371 IPI:RGD F MDM2/MDM4 family protein binding
GO:0051525 IPI:RGD F NFAT protein binding
GO:0000978 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001077 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190 IEA:Ensembl F RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0008144 ISS:UniProtKB F drug binding
GO:0004879 IMP:RGD F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008289 ISS:UniProtKB F lipid binding
GO:0019902 IPI:RGD F phosphatase binding
GO:0032403 IMP:RGD F protein complex binding
GO:0019904 IDA:RGD F protein domain specific binding
GO:0003707 TAS:RGD F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0035095 IDA:RGD P behavioral response to nicotine
GO:0032922 ISS:UniProtKB P circadian regulation of gene expression
GO:0070166 IEA:Ensembl P enamel mineralization
GO:0008544 IEA:Ensembl P epidermis development
GO:0006631 IMP:RGD P fatty acid metabolic process
GO:0007507 IEP:RGD P heart development
GO:0030522 IMP:GOC P intracellular receptor signaling pathway
GO:0042157 IMP:RGD P lipoprotein metabolic process
GO:0032099 ISS:UniProtKB P negative regulation of appetite
GO:0045776 IMP:RGD P negative regulation of blood pressure
GO:0010887 IEA:Ensembl P negative regulation of cholesterol storage
GO:1901215 IDA:RGD P negative regulation of neuron death
GO:0032091 IMP:RGD P negative regulation of protein binding
GO:0010871 IEA:Ensembl P negative regulation of receptor biosynthetic process
GO:0010891 IEA:Ensembl P negative regulation of sequestering of triglyceride
GO:2000678 IMP:RGD P negative regulation of transcription regulatory region DNA binding
GO:0046321 IEA:Ensembl P positive regulation of fatty acid oxidation
GO:0045722 IEA:Ensembl P positive regulation of gluconeogenesis
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0072366 IEA:Ensembl P regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752 ISS:UniProtKB P regulation of circadian rhythm
GO:0019217 TAS:RGD P regulation of fatty acid metabolic process
GO:0072363 IEA:Ensembl P regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 IEA:Ensembl P regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:RGD P regulation of transcription, DNA-templated
GO:0001666 IDA:HGNC P response to hypoxia
GO:0032868 IMP:RGD P response to insulin
GO:0042060 IEA:Ensembl P wound healing

KEGG Pathway Links

KEGG Pathway ID Description
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko05160 Hepatitis C
rno05160 Hepatitis C
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5954332 BMAL1:CLOCK,NPAS2 activates circadian gene expression
5954223 Circadian Clock
5953533 Developmental Biology
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953330 Gene Expression
5953833 Generic Transcription Pathway
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953600 Mitochondrial biogenesis
5954147 Nuclear Receptor transcription pathway
5953601 Organelle biogenesis and maintenance
5954333 PPARA activates gene expression
5954224 REV-ERBA represses gene expression
5954225 RORA activates circadian gene expression
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5953599 Transcriptional activation of mitochondrial biogenesis
5954166 Transcriptional regulation of white adipocyte differentiation
5954528 YAP1- and WWTR1 (TAZ)-stimulated gene expression

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003074 Peroxisome proliferator-activated receptor
IPR003076 Peroxisome proliferator-activated receptor, alpha
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator activated receptor alpha
Protein Entry
PPARA_RAT
UniProt ID
P37230
Species
Rat

Comments

Comment Type Description
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity)
Ptm Phosphorylated
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus.
Subunit Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 AND ASXL2. Interacts with PER2 (By similarity)
Tissue Specificity Expressed predominantly in liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP012557 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981382 RefSeq NP_037328 468 peroxisome proliferator-activated receptor alpha

Identical Sequences to LMP012557 proteins

Reference Database Accession Length Protein Name
GI:6981382 GenBank AAA41918.1 468 peroxisome proliferator activated receptor [Rattus norvegicus]
GI:6981382 GenBank EDM15573.1 468 peroxisome proliferator activated receptor alpha [Rattus norvegicus]
GI:6981382 RefSeq XP_006242218.1 468 PREDICTED: peroxisome proliferator-activated receptor alpha isoform X1 [Rattus norvegicus]
GI:6981382 SwissProt P37230.1 468 RecName: Full=Peroxisome proliferator-activated receptor alpha; Short=PPAR-alpha; AltName: Full=Nuclear receptor subfamily 1 group C member 1 [Rattus norvegicus]

Related Sequences to LMP012557 proteins

Reference Database Accession Length Protein Name
GI:6981382 GenBank AAA41918.1 468 peroxisome proliferator activated receptor [Rattus norvegicus]
GI:6981382 RefSeq XP_006242218.1 468 PREDICTED: peroxisome proliferator-activated receptor alpha isoform X1 [Rattus norvegicus]
GI:6981382 SwissProt P37230.1 468 RecName: Full=Peroxisome proliferator-activated receptor alpha; Short=PPAR-alpha; AltName: Full=Nuclear receptor subfamily 1 group C member 1 [Rattus norvegicus]