Gene/Proteome Database (LMPD)

LMPD ID
LMP012560
Gene ID
26194
Species
Rattus norvegicus (Rat)
Gene Name
['NADH dehydrogenase subunit 2']
Gene Symbol
ND2
Alternate Names
NADH dehydrogenase subunit 2;
EC Number
1.6.5.3

Proteins

NADH dehydrogenase subunit 2 [Rattus norvegicus]
Refseq ID YP_665630
Protein GI 110189716
UniProt ID Q8HID0
Length 346
MNPITLIIIYFTILMGPVITMSSSNLLLMWVGLEMSLLAIIPLLANKKSPRSTEAATKYFLTQATASMIILLVIILNYKQSGMWTLQQQTNNMLLNMMLISLAMKLGLAPFHYWLPEVTQGIPLHIGLILLTWQKIAPLSILYQFYQLLNPTITTILAISSVFVGAWGGLNQTQTRKIMAYSSIAHMGWMTAILPYNPNLTLLNLTIYILLTVPMFITLMTNSATTINTLSLAWNKTPMILTMTSIILLSLGGLPPLTGFLPKWAIISELLKNNCSTLSTLMAIMALLSLFFYTRLIYSMSLTMFPTNNNSKMISHHHQNPKHNFILPTLTVLSTLTLPLSSQLIT

Gene Information

Entrez Gene ID
26194
Gene Name
['NADH dehydrogenase subunit 2']
Gene Symbol
ND2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005747 IEA:Ensembl C mitochondrial respiratory chain complex I
GO:0008137 IEA:UniProtKB-EC F NADH dehydrogenase (ubiquinone) activity
GO:0006120 IEA:InterPro P mitochondrial electron transport, NADH to ubiquinone
GO:0072593 IEA:Ensembl P reactive oxygen species metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
M00142 NADH:ubiquinone oxidoreductase, mitochondria
ko00190 Oxidative phosphorylation
rno00190 Oxidative phosphorylation
rno05012 Parkinson's disease

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953747 Respiratory electron transport
5953748 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR010933 NADH dehydrogenase subunit 2, C-terminal
IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
IPR003917 NADH:ubiquinone oxidoreductase, chain 2

UniProt Annotations

Entry Information

Gene Name
['NADH dehydrogenase subunit 2']
Protein Entry
Q8HID0_RAT
UniProt ID
Q8HID0
Species
Rat

Comments

Comment Type Description
Catalytic Activity NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093735}.
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Similarity Belongs to the complex I subunit 2 family
Subcellular Location Mitochondrion inner membrane ; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012560 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
110189716 RefSeq YP_665630 346 NADH dehydrogenase subunit 2 [Rattus norvegicus]

Identical Sequences to LMP012560 proteins

Reference Database Accession Length Protein Name
GI:110189716 GenBank AIU45680.1 346 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]
GI:110189716 GenBank AIU45693.1 346 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]
GI:110189716 GenBank AIU45706.1 346 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]
GI:110189716 GenBank AIY51543.1 346 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]

Related Sequences to LMP012560 proteins

Reference Database Accession Length Protein Name
GI:110189716 GenBank AAN77595.1 346 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]
GI:110189716 GenBank AIU45576.1 346 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]
GI:110189716 GenBank AIY51543.1 346 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]